and Alzheimer’s Disease - The Physicians Committees.pdfFood Addictions, Diabetes, and...
Transcript of and Alzheimer’s Disease - The Physicians Committees.pdfFood Addictions, Diabetes, and...
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Food Addictions, Diabetes,
and Alzheimer’s Disease
Breaking the Food Seduction
Neal D. Barnard, MD
Adjunct Associate Professor of Medicine
George Washington University School of Medicine
Physicians Committee for Responsible Medicine
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Glucose Insulin
Intramyocellular lipid
Inside the Cell
●
● ● ● ●
● ● ●
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Plant-Based Diet for Type 2 Diabetes
Low-fat low-GI vegan diet vs ADA guidelines
22-week study, 1-year follow-up
n = 99
Barnard ND, et al. Diabetes Care 2006;29:1777-1783.
Barnard ND, et al. Am J Clin Nutr 2009;89(suppl):1588S-96S.
Funding: NIDDK; Diabetes Action Research and Education
Foundation
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P = .089
8.05
7.93
7.37
7.08
Hemoglobin A1c at Baseline and at 11 and 22 Weeks
(n = 49 vegan, 50 ADA)
Week 0 Week 11 Week 226.5
7.0
7.5
8.0
8.5
Vegan
ADA
A1c (%)
7.33 7.34
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Hemoglobin A1c at Baseline and at 11 and 22 Weeks
Week 0 Week 11 Week 226.5
7.0
7.5
8.0
8.5
Vegan
ADA
Individuals with no medication changes, n = 24 vegan, 33 ADA
P = 0.01
8.07
7.88
7.42
7.18
7.50
6.84
A1c (%)
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Hemoglobin A1c, All Participants
(n = 49 vegan, 50 ADA)
0 11 22 35 48 61 746.5
7.0
7.5
8.0
8.5
Vegan
ADA
Data shown are last values before any change to hypoglycemicmedications carried forward. For between-group comparison of changesfrom baseline to final values, P = 0.03.
Weeks
7.65
7.948.05
7.93
P = 0.03
A1c (%)
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Dopamine
Responsible for feelings of pleasure or
reward.
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The DRD2 Taq1 Allele
The A1 allele is associated with a
reduction in dopamine receptors.
Noble EP. The DRD2 gene in psychiatric and neurological disorders and its
phenotypes. Pharmacogenomics. 2000;:309-33.
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DRD2 Genotypes
A1A1, A1A2 (A1+) A2A2 (A1 -)
Noble EP. The DRD2 gene in psychiatric and neurological disorders and its
phenotypes. Pharmacogenomics. 2000;:309-33.
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DRD2 Genotypes
A1A1, A1A2 (A1+) A2A2 (A1 -)
12 - 40% of U.S. adults 60 – 88% of U.S. adults
Fewer dopamine receptors Normal number of receptors
Higher risk of:
Smoking
Alcohol or drug abuse
Compulsive gambling
Compulsive overeating
Noble EP. The DRD2 gene in psychiatric and neurological disorders and its
phenotypes. Pharmacogenomics. 2000;:309-33.
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DRD2 Substudy
Is the presence of the DRD2 A1 allele associated
with poorer response to therapeutic diets?
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DRD2 A1 Genotype Prevalences
A1+ : 49% (10% A1A1, 39% A1A2)
A1- : 51% (A2A2)
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Diet and Body Weight by Genotype,
Black Participants
A1 - A1+ P-value
Fat (% energy)
34.7 (1.5) 41.7 (1.5) 0.002
Saturated fat (%
energy)
10.5 (0.6) 12.7 (0.6) 0.01
Carbohydrate (%
energy)
47.6 (1.7) 41.4 (1.8) 0.02
Cholesterol
(mg/1000 kcal)
144 (13) 197 (16) 0.02
Weight
99.2 (4.8) 110.4 (3.1) 0.05
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Diet and Body Weight by Genotype,
White Participants
A1 - A1+ P-value
Fat (% energy)
36.3 (1.4) 32.8 (1.5) 0.09
Saturated fat (%
energy)
12.0 (0.7) 11.0 (0.7) 0.31
Carbohydrate (%
energy)
44.7 (2.0) 50.7 (1.6) 0.03
Cholesterol
(mg/1000 kcal)
179 (16.7) 151 (22.9) 0.32
Weight
94.8 (4.4) 92.2 (5.0) 0.70
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Hemoglobin A1c, Black Participants(n = 22 vegan, 22 ADA)
0 747.0
7.5
8.0
8.5
Black Vegan
Black ADA
Data shown are last values before any change tohypoglycemic medications carried forward.
Weeks
7.80
7.94
8.29
7.70
P = 0.02
A1c (%)
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Hemoglobin A1c, White Participants(n = 25 vegan, 24 ADA)
0 747.0
7.5
8.0
8.5
Data shown are last values before any change tohypoglycemic medications carried forward.
Weeks
7.58
7.927.91
8.15
P = 0.65
White Vegan
White ADA
A1c (%)
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A1c Changes with Diet Intervention
(0-74 weeks)
A1 - A1+ P-value
A1c change,
blacks
-0.72 (0.41) -0.40 (0.27) 0.50
A1c change,
whites
-0.89 (0.27) -0.02 (0.18) 0.01
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Substudy Hypothesis
The A1 allele may contribute to overeating
and weight gain, increasing diabetes risk.
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Can foods be addicting?
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How to Magnetize a Baby
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• Baby, 9 –12
weeks of age
• Sit face-to-face,
15 inches apart
Smith BA. Devel Psychol 1990;26:731-7.
Blass EM. Monogr Soc Res Child Dev 1994;59:1-96.
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1 tsp sugar + 1 cup water
Smith BA. Devel Psychol 1990;26:731-7.
Blass EM. Monogr Soc Res Child Dev 1994;59:1-96.
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Blass EM. Devel Psychol 2001;37:762-74.
University of Massachusetts at Amherst
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Blass EM. Devel Psychol 2001;37:762-74.
University of Massachusetts at Amherst
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Sugar
Sugar → opiate release → ↑ dopamine
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Sugar
• Reduces crying in healthy newborns
• Reduces visible reaction to heel-stick
and circumcision
• No effect in infants of opiate-addicted
mothers
Smith BA. Devel Psychol 1990;26:731-7.
Blass EM. Monogr Soc Res Child Dev 1994;59:1-96.
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Is Sugar a Problem?
Sugar, 1 teaspoon
Chocolate chip cookies (2)
Soda, 20 ounces
Twizzlers (2.5 oz.)
Calories
15
90
250
263
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Soda Serving Sizes
6-ounce bottles
12-ounce cans
16-ounce bottles
20-ounce bottles
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Cola (20 oz.)
• 68 grams sugar + 78 mg caffeine
• 250 calories
Pennington, Bowes and Church's Food Values of Portions Commonly
Used (Philadelphia: Lippincott-Raven, 1998)
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Spot the Addicting Food
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The Chocolate Drugstore
Caffeine (5-10 mg)*
Theobromine
Phenylethylamine
Slows breakdown of anandamide
*Compare to coffee (100 mg)
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Casomorphins
Opiates that form as casein (milk protein) is digested.
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Casomorphins
From ß-casein:
ß-casomorphin-7 Try-Pro-Phe-Pro-Gly-Pro-Ile
ß-casomorphin 5 (bovine) Tyr-Pro-Phe-Pro-Gly
ß-casomorphin 5 (human) Tyr-Pro-Phe-Val-Glu
Morphiceptin Tyr-Pro-Phe-Pro-NH2
From as1-casein:
a-Casein exorphin Arg-Gly-Phe-Gin-Asn-Ala
Shah NP. Br J Nutr 2000;84(suppl 1):S3-S10.
Teschemacher H. J Dairy Res 1986;53:135-8.
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Cheese (2 oz.)
Brie
Cheddar
Feta
Goat
Mozzarella
Swiss
Calories
190
228
150
206
160
214
Fat (grams)
16
19
12
17
12
16
Pennington, Bowes and Church's Food Values of Portions Commonly
Used (Philadelphia: Lippincott-Raven, 1998)
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Cholesterol (per ounce)
Brie
Cheddar
Feta
Roast sirloin
Chicken breast, skinless
Salmon, Atlantic
Beans, grains
Vegetables, fruits
Cholesterol
28
30
25
25
24
20
0
0
Pennington, Bowes and Church's Food Values of Portions Commonly
Used (Philadelphia: Lippincott-Raven, 1998)
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Wendy’s “Cheddar Lover’s Bacon
Cheeseburger” promotion sold:
• 2.25 million pounds of cheese
• 380 tons of fat
• 1.2 tons of pure cholesterol
USDA Report to Congress on the Dairy
Promotion Programs, 2000
The U.S. Government at Work
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• Wendy’s “Cheddar Lover’s Bacon
Cheeseburger”
• Subway’s “Chicken Cordon Bleu,” “Honey
Pepper Melt”
• Pizza Hut’s “Ultimate Cheese Pizza”
• Burger King, Taco Bell
USDA Report to Congress on the Dairy Promotion Programs, 2000
The U.S. Government at Work
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Dick Cooper, Vice President of Cheese Marketing, Dairy Management, Inc., at the
“Cheese Forum,” December 5, 2000.
USDA Report to Congress on the Dairy Promotion Programs, 2000
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“Would you give up meat for
a week for $1,000?”
1,244 adults, surveyed April 2000
Answered “No”:
White Americans: 24%
Black Americans: 29%
Asian Americans: < 10%
Hispanic Americans: < 10%
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Opiate Blocker Cuts Meat Appetite
Ham ↓ 10%
Salami ↓ 25%
Tuna ↓ ~ 50%
Yeomans MR, Wright P, Macleod HA, Critchley JAJH. Effects of nalmefene on
feeding in humans. Psychopharmacology 1990;100:426-32.
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Benefits of Meatless Diets
• Reverse heart disease
• Lose ~ 10% of body weight
• ↓ cancer risk by ~ 40%
• ↓ blood pressure
• Improve or reverse diabetes
• ↓ risk of Alzheimer’s disease?
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Top 5 Rationalizations
1. I’m a blood type O, so I have to eat meat.
2. I can exercise these extra calories off.
3. Diet advice is always changing. Just eat
what you want.
4. Healthy eating is expensive.
5. My grandfather smoked, drank, and ate all
the wrong things and lived to be 90.
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Care-Givers’ Rationalizations
1. There are no bad foods, only bad diets.
Everything in moderation.
2. We have to follow people’s tastes and
cultures.
3. My patients would rather just pop a pill.
4. We need more research before we can say
anything.
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Breaking Free from Food Cravings
1. Start with a healthy breakfast
2. Use foods to hold blood sugar steady
3. Dieters: Use the Rule of Ten
4. Break craving cycles
5. Have regular exercise and rest
6. Use social support
7. Take advantage of other motivators
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Norm
al
Dia
betes
0.0
0.5
1.0
1.5
2.0
P = 0.01
HR
Risk of Alzheimer’s disease based on glucose tolerance results 15 years earlier.
Ohara T. Neurology. 2011;77:1126-34.
Diabetes and Alzheimer’s Risk
1,017 adults
Hisayama, Japan
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Risk of Alzheimer’s disease based on glucose tolerance results 15 years earlier.
Ohara T. Neurology. 2011;77:1126-34.
Diabetes and Alzheimer’s Risk
1,017 adults
Hisayama, Japan
0.0
0.5
1.0
1.5
2.0
2.5
3.0
3.5
P < 0.001
Plasma Glucose (2 hour post-prandial)
<120 (6.7) >200 (11.1)
HR
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Mechanisms
Cerebrovascular disease
Glucose toxicity
Glycation of brain proteins
Microvascular changes
Hyperinsulinemia
Effects of insulin on brain vasculature
Insulin ↑ β-amyloid secretion and ↓ elimination
Biessels GJ. Lancet Neurology. 2006;5:64-74.
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2010 2020 2030 2040 20500
5
10
15
Alzheimer's Prevalence in the U.S.(m
illio
ns)
Hebert LE. Arch Neurol. 2003;60:1119-1122
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Memory Problems
Lapses
Mild cognitive impairment
• Learning, remembering
• Reasoning
• Visual-spatial ability
• Language
• Personality
Alzheimer’s disease
=
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APOE epsilon-4 Allele
From one parent: 3x risk
From both parents: 10 - 15x risk
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Chicago Health
and Aging Project
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Saturated Fat
13 grams 25 grams
0
1
2
3
4
Alzheimer’s Risk
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Add Up the Saturated Fat
2 large eggs 3.2 g
1 slice bacon 1.0 g
Chicken thigh, skinless 4.7 g
Whole milk (1 cup) 4.6 g
DiGiorno Pizza for One 12.0 g
Total 25.5 g
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Cardiovascular risk factors, Aging, and
Dementia (CAIDE) study, Finland
Eskelinen MH. Int J Geriatric Psychiatr.
2008; 23: 741–747.
1,341 adults
Average age: 50
Followed 21 years
Mild Cognitive Impairment
0
0.5
1
1.5
2
2.5
Saturated fat per day
Low
(<21.6 grams)
High
(>21.6 grams)
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Cardiovascular risk factors, Aging, and
Dementia (CAIDE) study, Finland
Eskelinen MH. Int J Geriatric Psychiatr.
2008; 23: 741–747.
1,341 adults
Average age: 50
Followed 21 years
Mild Cognitive Impairment APOEε4
0
1
2
3
4
5
6
Low
(<21.6 grams)
High
(>21.6 grams)
Saturated fat per day
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Trans Fats
0
1
2
3
4
5
6
Low:
1.8 grams
High:
4.8 grams
Alzheimer’s Risk
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Cholesterol and Alzheimer's Risk
<198
198-
220
221-
248
249+
0
1
2
Serum Cholesterol (mg/dL)
Rela
tive R
isk
9,844 participants in the Kaiser Permanente health plan.
Solomon A. Dement Geriatr Cogn Disord. 2009;28:75–80.
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Alzheimer's Risk
25.1
0
1
2
3
4
Saturated Fat per Day (grams)
Rela
tive
Ris
k
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Alzheimer's Risk
25.1
20.7
0
1
2
3
4
Saturated Fat per Day (grams)
Rela
tive
Ris
k
Alzheimer's Risk
25.1
0
1
2
3
4
Saturated Fat per Day (grams)
Rela
tive
Ris
k
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Alzheimer's Risk
25.1
20.7
13.0
0
1
2
3
4
Saturated Fat per Day (grams)
Rela
tive
Ris
k
Alzheimer's Risk
25.1
20.7
0
1
2
3
4
Saturated Fat per Day (grams)
Rela
tive
Ris
k
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Alzheimer's Risk
25.1
20.7
13.0 3.
3
0
1
2
3
4
Saturated Fat per Day (grams)
Rela
tive
Ris
k
?
Alzheimer's Risk
25.1
20.7
13.0
0
1
2
3
4
Saturated Fat per Day (grams)
Rela
tive
Ris
k
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Meat vs. Plant-Based Diets
Proportion remaining
free of dementia
Loma Linda University, 272 participants
Giem P. Neuroepidemiology. 1993;12:28-36.
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Meat vs. Plant-Based Diets
Loma Linda University, 272 participants
Giem P. Neuroepidemiology. 1993;12:28-36.
Proportion remaining
free of dementia
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Summary
Diet changes may be more challenging in
the face of:
• adverse genetic traits
• easy availability of habit-forming foods
• rationalizations
Unhealthful foods contribute to diabetes
and other health problems, including
dementia.
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Thank you!
Neal D. Barnard, MD
Adjunct Associate Professor of Medicine
The George Washington University School of Medicine
Physicians Committee for Responsible Medicine
pcrm.org