Anatomical Engineering for the Intelligent Design of Medical Devices

Crispin B. Weinberg, Ph.D.| President Danice Y. Chou, B.S.| Biomedical Engineer Biomedical Modeling, Inc.| www.biomodel.com

Anatomical Engineering

for Intelligent Design of Medical Devices

Biomedical Modeling, Inc. Canadian Manufacturing Technology Show: Medical Manufacturing Inovation Series

Biomedical Modeling, Inc. 2013

About Biomedical Modeling, Inc.

What is Anatomical Engineering?

Process Overview

Examples

Why Anatomical Engineering?


for Intelligent Design of Medical Devices

We are a Boston-based biomedical engineering company that makes

patient-specific anatomical models from medical imaging data (CT, MRI).

Biomedical Modeling, Inc.
Patient-specific models & design services for dental, medical, engineering, and research applications.

About Us

Anatomical engineering consists of extracting 3D information from medical imaging data (e.g. CT, MRI) and modeling such data using reverse engineering, CAD, & additive fabrication techniques.

What is Anatomical Engineering?


Additive Fabrication Data Segmentation Data Acquisition Problem Definition 3D Modeling(mesh) CAD Modeling (NURBS) The Process

Process Overview

(For more details, see our Biomodeling Process presentation.)

Device Design & Evaluation

Simulation Models

Surgical Guides

Personal Prosthetics

Custom Implants

Bioprinted Tissues & Organs

Anatomical Engineering Examples

Examples



Minimally Invasive Cardiovascular Devices

Left: Jarvik Heart, Inc. http://www.jarvikheart.com/basic.asp?id=21 ; Right: Y. Bazilevs, et. al., Patient-specific isogeometric fluid-structure interaction analysis of thoracic aortic blood flow due to implantation of Jarvik 2000 Left Ventricular Assist Device, Computer Methods in Applied Mechanics and Engineering, vol. 198, issue 45-46, 2009. http://www.sciencedirect.com/science/article/pii/S0045782509001674


Univ. of CA Univ. of TX Carnegie Mellon Univ.

CFD of LVAD Blood Flow

Simulation Models

Biomedical Modeling, Inc. | Materialise

Airways & Gas Exchange

Left: Biomedical Modeling, Inc. www.biomodel.com ; Right: Materialise and P.J. Antunes, University of Minho, Portugal. http://biomedical.materialise.com/engineering-services-engineering-anatomy

Coffey et.al., Interactive Slice WIM: Navigating & Interrogating Volume Data Sets Using a Multi-surface, Multitouch VR Interface, IEEE Trans. Visualization and Computer Graphics, vol. 8, no. 10, Oct. 2013. http://www.computer.org/csdl/trans/tg/2012/10/ttg2012101614-abs.html

Simulation Models

University of Minnesota

Interactive Slice World-In-Miniature

Phantom Haptic Stylus and Surgical Rehersal Platform (SRP). http://www.3dsystems.com/learning-center/case-studies/doctors-practicing-computers-not-patients#.UiXVNT95ESY

Simulation Models

Surgical Theater LLC

VR with Multi-sensory Feedback

Biomedical Modeling, Inc. | University of IL, Peoria

Pediatric Neurosurgical Training

Upper left: http://www.cdc.gov/ncbddd/spinabifida/facts.html. Right: Biomedical Modeling, Inc. & Univ. of Illinois College of Medicine, Peoria. J. Lin et. al., A Surgical Simulation Model for Myelomeningocele Repair, J. Med. Devices 7(2), 020924 (Jun 12, 2013).

Simulation Models

Surgical Guides

Biomedical Modeling, Inc. 3D Diagnostix

Biomodels & Dental
Drilling Guides

Surgical Guides

Reconstructive Surgery


Patient-specific modelwith tumor in red

Reconstruction model guidewith mirrored anatomy

Surgical Guides

Biomedical Modeling, Inc. Beth Israel Deaconess Med. Center

Tumor Resection vs.
Liver Transplant

Personalized Prosthetics

Patient-specific Hearing Aids

Left: http://i.materialise.com/blog/entry/3d-printing-in-medicine-what-is-happening-right-now-in-patients ; Right: http://www.forbes.com/sites/rakeshsharma/2013/07/08/the-3d-printing-revolution-you-have-not-heard-about/

Materialise Starkey


Invisalign

Left: http://www.rothmoonortho.com/kansas-city-orthodontic-treatment/kansas-city-invisalign/ ; Upper right: http://www.additive3d.com/rm_30.htm ; Lower right: http://enhancedental.com/invisalign/invisalign-procedure/

Orthodontic Tooth Aligners


Custom Bridges, Copings, &
Partial Dentures

Left: 3D Systems, e-stone material on ProJet 6000 system. http://silversmilesurvival.wordpress.com/tag/3d-printing/ ; Upper right: http://3dsystems.intercept-corp.com/ProJet-DP-3500.html ; Lower right: www.dentalproductsreport.com

3D Systems

Why are you trying to hide it? Lets show this thing off.


Bespoke Innovations

Prosthetic Limb Fairings

http://www.bespokeinnovations.com

http://eksobionics.com/ekso


Berkley Bionics Ekso Bionics

Powered Exoskeleton


Nemours/Alfred I. duPont Hospital for Children

Delaware Hospital, Mfg. Stratasys Corp., LAECO Othopedics. Left: Video still from http://www.youtube.com/watch?v=WoZ2BgPVtA0&feature=youtu.be ; Upper right: http://www.stratasys.com/resources/case-studies/medical/nemours ; Lower right: http://www.fastcodesign.com/1670482/3-d-printed-magic-arms-let-a-toddler-hug-and-play#6

Patient-specific Exoskeleton

Patient-specific Implants

Craniofacial Templates


Left: Biomedical Modeling, Inc., Boston, MA, USA. http://www.biomodel.comRight: Planmeca Oy, Helsinki, FIN. http://www.planmeca.com/en/CADCAM/Planmeca-Promodel-service/


Orbital Templates

Biomedical Modeling, Inc. Planmeca Oy

Left: http://www.eos.info/news_events/newsletter/edition_08_2012 ; Upper right: http://polymerinnovationblog.com/3d-printing-of-medical-implants-is-on-the-way/; Lower right: http://www.makepartsfast.com/2009/03/710/new-materials-for-laser-sintering/

PEKK


EOS Oxford Performance Materials

Direct Additive Manufacturing
of Cranial Plates


Hasselt University LayerWise Xiloc Medical

Direct Additive Manufacturing
of Maxillofacial Implants

Implant 3D-printed from powedered Ti with bioceramic coating, to replace mandible damaged due to osteomyelitis infection.Right: http://www.futureearth.com.au/science/3d-printing-woman-receives-jaw-implant/ ; Left: Yorick Jansens, AFP Collection, Getty Images 138078671, February 2, 2012.

Metal-sintered
Orthopedic Implants


Within Medical EOS

Upper left: http://www.nsf.gov/od/lpa/news/02/3dprinttip_images.htm. Right, lower left: EOS, Within. Titanium acetabular cup implant and spinal implants manufactured by DMLS systems. http://gfxspeak.com/2012/10/17/eos-teams-with-medical-implant-designer-to-advance-3d-printing-in-medicine/

Guided Tissue Regeneration

G. Green, S. Hollister, University of Michigan

Printed Resorbable Trachea Splint

Polycaprolactone printed trachea splint for 6-week olf patient with collapsed bronchial tube at C.S. Mott Childrens Hospital.http://www.engin.umich.edu/college/about/news/stories/2013/may/3d-printed-splint-saves-life

Bio-printed Tissues & Organs

L. Bonassar, Weill Cornell Medical College

Artificial Ears from 3D-printed Molds

Lindsay France | University Photography. http://www.news.cornell.edu/stories/2013/02/bioengineers-physicians-3-d-print-ears-look-act-realCells from cow ears (collagen scaffold from rat tails) encapsulated in a hydrogel, and injected into mold.


Bioprinted Blood Vessels

Left and upper right: Rep Rap 3D Printing Blood vessels, http://www.youtube.com/watch?v=9VHFlwJQIkE ; Lower right: Printed from NovoGen MMX Bioprinter. http://www.oldthinkernews.com/2010/12/first-fully-bioprinted-blood-vessels/ ; http://iopscience.iop.org/1758-5090/4/2/022001/article

Univ. of Pennsylvania Organovo Invetech

tedx http://ed.ted.com/lessons/printing-a-human-kidney-anthony-atala


A. Atala, Wake Forest Institute for Regenerative Medicine

3D-printed Liver Tissue

Engineering Human Liver Tissue, Anthony Atala: Printing a Human Kidney, Ted Talks Ted2011. http://www.ted.com/talks/anthony_atala_printing_a_human_kidney.html


Bio-printed organs to date

A. Atala, Wake Forest Institute. http://www.bbc.com/future/story/20120621-printing-a-human-kidney

Bladder

Kidneys

Liver

Heart Valves

Blood vessels

Nerve Grafts, Skin

Anatomical engineering formedical device design, simulation, and testing.


Anatomical engineering fortissue and organ replacement.

Left: Rendering of 3D skull model with cranial implant, www.biomodel.com ; Right: Rendering of 3D printing skin cells onto burn wound, a method currently undergoing clinical trials in mice at Wake Forest Institute. http://www.3dprinterworld.com/article/wake-forest-3d-prints-skin-cells-burn-wounds


Biomedical Modeling, Inc. 2013

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Anatomical Engineering for the Intelligent Design of Medical Devices

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