Analgin | apollo +9191 46 950 950 Analginapollopharma.in/pdf/Analgin.pdf · synthesis of endogenous...
Transcript of Analgin | apollo +9191 46 950 950 Analginapollopharma.in/pdf/Analgin.pdf · synthesis of endogenous...
Analgin | apollo +9191 46 950 950
Analgin | apollo +9191 46 950 950
Analgin
CAS Number : 5907-38-0
Molecular Weight : 333.34 g/mol
Molecular Formula : C13H16N3O4S.Na
Systematic (IUPAC) : Metamizole sodium ; Analgin; Novalgin ; Dipyrone;[(2,3-dihydro-1,5-dimethyl-3-oxo-
2-phenyl-1H-pyrazol-4 -y l)methylamino]methanesulfonte
Application
Analgin is Antipyretic analgesics of Pyrazolones. It indicated for treatment diseases caused by high fever
and various pain. It is also indicated in fever, headache, rheumatic pain, neuralgia and dysmenorrheal ect. It is freely soluble in water and rapidly effect. It is prepared
ampoules .
Package : 25kg/ drum
Period of retest : three years .
Indications
Analgin tablets are used for the treatment of pains of different origin and variable intensity: toothache, headache, arthralgia, neuralgia, myositis, mild to
moderate visceral pain, high fever, not responding to other drugs. Analgin injection is used in cases of acute
and severe pain after operations and traumas, pain associated with neoplastic diseases, colicky pain etc.
Dosage and administration
Ampoules: The ampoules can be administered intramuscularly. The single dose in all age groups is 8 to
16 mg/kg body weight. The dose should be given according to the following scheme: 16 to 31 kg body weight - 250 mg Analgin (1/2 ml); 32 to 46 kg body
weight - 500 mg Analgin (1 ml); 47 - 62 kg body weight - 500 - 750 mg Analgin (1 - 1.5 ml); and over 63 kg body weight - 750 - 1000 mg Analgin (1.5 - 2 ml). In cases of
persistent pain, the dose can be repeated after 6 to 8 hours. Maximum daily dose - 4.0 g Analgin. Analgin
should not be used parenterally for a period longer than 3 days. Tablets: The dosage and duration of the
treatment must be determined according to the severity of the pain syndrome. The common dose in the adults is
250 to 500 mg (1 to 2 tablets) 2 or 3 times daily. The maximum dose is 3 g/24h. In over 15 year-old children
the Analgin dose is 250 mg bid or tid.
Contraindications
Hypersensitivity to metamizole and other pyrazolone derivatives, acute hepatic porphyria, inborn glucose-6-phosphate dehydrogenase deficiency, severe renal or
hepatic diseases, blood diseases (such as aplastic anemia, leucopenia and agranulocytosis), pregnancy
(the first and the last trimester). Parenteral administration of Analgin is contraindicated in under 1
year-old children.
Special warnings and precautions
Analgin is used with increased caution in patients with a history for hypersensitivity to foods and drugs
(particularly to analgesic and nonsteroidal antiinflammatory agents) and also in patients suffering
from bronchial asthma, Quincke’s edema, chronic pulmonary infections. In patients with hypotension and
unstable blood pressure, Analgin should not be used parentarally. If Analgin application is quite necessary,
the blood pressure and the heart rate should be monitored. In cases of prolonged Analgin treatment, regular blood count checks are necessary (differential
count of the white blood cells). The high Analgin doses can influence unfavourably the active attention. Because of this in these cases driving and working with machines
are not advised.
Drug interactions
Analgin potentiates the analgesic and antipyretic action of the nonsteroidal antiinflammatory drugs. The Analgin
effects are potentiated by the tricyclic antidepressants, oral contraceptive agents, allopurinol, alcohol. Analgin decreases the activity of the coumarin anticoagulants
and plasma levels of cyclosporin. The enzyme inductors (barbiturates, glutethimide, phenylbutazone) attenuate
the Analgin effects. Analgin potentiates the effects of the drugs possessing CNS depressant activity. Concurrent administration with chlorpromazine is related with a
risk of severe hypothermia. Analgin can be used in combination with buscolysin, atropin, codein.
Adverse reactions
After prolonged administration very rarely can be observed agranulocytosis, leucopenia and
thrombocytopenia, proteinuria, interstitial nephritis. In sensitive patients rashes, urticaria, Quincke’s edema, asthmatic attacks, and very rarely anaphylactic shock
are possible.
Pharmacological mechanisms
Analgin is a medicine of the pyrazolone group, possessing hard analgesic and antipyretic effects and moderate antiinflammatory activity. Blocking of the
synthesis of endogenous pyrogens - prostaglandins D and E - is the cause for the antipyretic activity and also
for the analgesic action of this drug. The decrease of the prostaglandis production in the periphery (and
respective decrease of nerve endings sensitivity) plays a relatively smaller role. In contrast to the other
nonnarcotic analgesic drugs, Analgin stimulates the release of β-endorphins, explaining its activity in cases
of visceral pain. Analgin has a slight spasmolytic activity on the smooth muscle cells of the biliary and urinary
tracts and also on the muscle of the uterus.
Description
It is an injectable suspension. Each ampoule contains 500mg metamizole sodium. Dosage is given as per by physician. They are stored and protected in a cool dry
place between 15-30 centigrade. Other specs can be provided according to customer's option.
Uses
Used for relieving pain
Used for relieving fever
Used in the treatment of respiratory, gastroenteritic and urogenital diseases, such as: asthma, pneumonia.
This medication is effective in blood poisoning and pyogenic dermatitis.
How to use \ dosage ?
They are used for relieving pain taken as a tablet or 20 drops orally each time, 3 to 4 times a day. In severe pain
1 - 2ml of 50% solution by intramuscularly or intravenous injections 1 -2 times a day. In exceedingly sharp pains: the dose may be increased to 5ml of 50%
solution administered intravenously.
Safety tips
It is used with care and doctor should know about patient deteriorates if any before taking the medication
such as :
Pregnancy
Asthma or chronic lung infection
Any allergy
Unstable blood pressure
Hypertension
NOTE : Not to be used in pregnant women
Common side effects
Diarrhea
Nausea
Rashes
Skin reactions
Red coloration of urine
Drop in blood pressure
Shock
Intolerance
Missed Dose
If you miss a dose take it as soon as you remember. However, if it is nearly time for the next dose, skip the
Missed Dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Storage
Store this medication at room temperature 15–30°C (59–86°F). Keep away from children and excess heat
and moisture (not in the bathroom).
More Information
You may need a dosage adjustment or special monitoring during treatment or you may not be able to take this drug at all if you have kidney or liver infection or if you have gastrointestinal problems. Analgin is in
the FDA pregnancy category C, which means that studies in animals have revealed adverse effects on the fetus
(teratogenic or embryocidal or other) and there are no controlled studies in women, or studies in women and
animals are not available. Also it is not known if Analgin passes into breast milk. Therefore, do not use Analgin
without your doctor`s approval if you are pregnant, likely to become pregnant or breast feeding. Patients
over 65 years of age may be more sensitive to the effects of Analgin. These patients are recommended to take a
lower dose of this drug, as they are more likely to experience side effects.
Warnings/Precautions
Analgin like other NSAID medicines may cause serious problems such as liver damage. Some of the symptoms of liver damage are nausea, vomiting, tiredness, loss of
appetite, itching, and yellow coloring of skin or eyes and dark urine. If you experience these conditions, you should stop taking Analgin and contact your doctor
immediately. Analgin may also cause bleeding stomach ulcers, especially if you take Analgin for a long time or/and if you take large doses of Analgin. Sudden
stomach bleeding is also possible. Contact your doctor immediately if you get a burning stomach pain, black
bowel movements that look like tar, vomit that looks like blood or coffee grounds.
apollo | asia Division
APOLLO Pharmaceuticals API Manufacturer INDIA [P] Ltd.|asia Division
Mr.Vipin Saxena|CEO
Cellular:+91-98-21050033
Cellular:+91-98-20150033
Direct :+91-22-65785588
FAX :+91-22-42950001
Wireline Purchase HELPDESK:
+91-22-65050001
+91-22-65650001
Wireline Sales HELPDESK:
+91-22-65500009
+91-22-65050009
Wireless 24x7 HELPDESK:
+9191-46-951951
+9191-46-950950
Blackberry Pin :
32E6500D | 32E65010 | 28415C58
Email:
www.apolloworld.in
www.apollopharma.in
www.apollopharmaceuticals.Net
Chat:
MSN Hotmail:VipinrSaxena
Skype NAME:VipinrSaxena
Rocketmail:VipinrSaxena
Google mail:VipinrSaxena
BlackBerry:28415C58
Regd. Office :-
1104, Maker Chamber V,
Nariman Point
Mumbai, INDIA
Pin:400021
Industrial Office
D-62, OIC India
Oshiwara Industrial Centre,
New Link Road,
Goregoan West,
Mumbai, INDIA
Pin:400104
Manufacturing Unit Address:
Plot No. 117A,
Village: Chamble
Near MonaTona Limited.Wada,
Maharashtra,
PIN : 421312 | INDIA
Email:
www.apollo.mn | www.apollo.com.co | www.apollopharmaceuticals.Com