An Overview of Gene Regulationfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W10/last...

7
An Overview of Gene Regulation

Transcript of An Overview of Gene Regulationfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W10/last...

Page 1: An Overview of Gene Regulationfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W10/last go...Transcription terminates. (D) In the absence of tryptophan, the ribosome stalls at the trp

An Overview of Gene Regulation

Page 2: An Overview of Gene Regulationfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W10/last go...Transcription terminates. (D) In the absence of tryptophan, the ribosome stalls at the trp

Genetic elements involved in regulation of the lac operong p

RN b d rRNA binding site

f l l f f Attenuation: fine scale control after initiation of transcription

Page 3: An Overview of Gene Regulationfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W10/last go...Transcription terminates. (D) In the absence of tryptophan, the ribosome stalls at the trp

Leader peptide rich in pathway AAsLeader peptide rich in pathway AAs

Page 4: An Overview of Gene Regulationfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W10/last go...Transcription terminates. (D) In the absence of tryptophan, the ribosome stalls at the trp

Leader encoded by domains 1 & 2y

Ribosome stalls waiting for TrpDomain 2:3 stem-loop forms

No termination!

Page 5: An Overview of Gene Regulationfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W10/last go...Transcription terminates. (D) In the absence of tryptophan, the ribosome stalls at the trp

Ribosome encounters no waitingDomain 3:4 stem-loop formsD ma n t m p f rm

Termination occurs due to inverted repeats and polyuridine!p p y

Page 6: An Overview of Gene Regulationfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W10/last go...Transcription terminates. (D) In the absence of tryptophan, the ribosome stalls at the trp

Attenuation: Th t f th tThe rest of the story

Page 7: An Overview of Gene Regulationfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W10/last go...Transcription terminates. (D) In the absence of tryptophan, the ribosome stalls at the trp

Global Control Systemsy


Phylogenetic Analysis - Western Washington Universityfire.biol.wwu.edu/cmoyer/zztemp_fire/biol432_S13/lec03...The evolution of β-defensin peptides in platypus venom gland. The diagram

Phylogenetic Analysis - Western Washington Universityfire.biol.wwu.edu/cmoyer/zztemp_fire/biol432_S13/lec03...The evolution of β-defensin peptides in platypus venom gland. The diagram

Microbial community structure of hydrothermal deposits ...fire.biol.wwu.edu/cmoyer/zztemp_fire/biol508_F12... · Microbial community structure of hydrothermal deposits from geochemically

Microbial community structure of hydrothermal deposits ...fire.biol.wwu.edu/cmoyer/zztemp_fire/biol508_F12... · Microbial community structure of hydrothermal deposits from geochemically

Lecture Series 3 The Organization of Cellsfire.biol.wwu.edu/cmoyer/zztemp_fire/biol205_W12/lect03.pdfThe Organization of Cells Reading Assignments • Read Chapter 15 Endomembrane

Lecture Series 3 The Organization of Cellsfire.biol.wwu.edu/cmoyer/zztemp_fire/biol205_W12/lect03.pdfThe Organization of Cells Reading Assignments • Read Chapter 15 Endomembrane

What is Microbiology? - OpenWebMailfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_F10/lect01_n3.pdf · Acellular Viruses nucleic acid ... Life was solely microbial ... Density does

What is Microbiology? - OpenWebMailfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_F10/lect01_n3.pdf · Acellular Viruses nucleic acid ... Life was solely microbial ... Density does

Bacterial bandits: bacteria in plant diseasefire.biol.wwu.edu/cmoyer/zztemp_fire/biol405_S08/plant.pdf · First disease where Koch’s postulates were fulfilled for plant bacterial

Bacterial bandits: bacteria in plant diseasefire.biol.wwu.edu/cmoyer/zztemp_fire/biol405_S08/plant.pdf · First disease where Koch’s postulates were fulfilled for plant bacterial

S08 Microbial Ecology Intro - OpenWebMailfire.biol.wwu.edu/cmoyer/zztemp_fire/biol405_S08/intro_lec3.pdf · Fundamental contribution to microbial ecology: showed that bacteria are

S08 Microbial Ecology Intro - OpenWebMailfire.biol.wwu.edu/cmoyer/zztemp_fire/biol405_S08/intro_lec3.pdf · Fundamental contribution to microbial ecology: showed that bacteria are

Mass Extinctions &Their Consequencesfire.biol.wwu.edu/cmoyer/zztemp_fire/biol432_S06/lec13_extinct_ho.… · e.g., Spore-bearing vs. flowering plants e.g., Dinosaurs and mammals at

Mass Extinctions &Their Consequencesfire.biol.wwu.edu/cmoyer/zztemp_fire/biol432_S06/lec13_extinct_ho.… · e.g., Spore-bearing vs. flowering plants e.g., Dinosaurs and mammals at

Earth History & the Fossil Recordfire.biol.wwu.edu/cmoyer/zztemp_fire/biol432_S13/lec05_fossils.pdf · What does the Fossil Record tell us? • OfhtitftiOccurrence of phenotypic transformations

Earth History & the Fossil Recordfire.biol.wwu.edu/cmoyer/zztemp_fire/biol432_S13/lec05_fossils.pdf · What does the Fossil Record tell us? • OfhtitftiOccurrence of phenotypic transformations

Comparative metagenomics of microbial communities ...fire.biol.wwu.edu/cmoyer/zztemp_fire/biol508_F12/Xie_metagenomic… · ORIGINAL ARTICLE Comparative metagenomics of microbial

Comparative metagenomics of microbial communities ...fire.biol.wwu.edu/cmoyer/zztemp_fire/biol508_F12/Xie_metagenomic… · ORIGINAL ARTICLE Comparative metagenomics of microbial

Microbial Taxonomy - Western Washington Universityfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_F07/lect03.pdfMicrobial Taxonomy Traditional taxonomy or the classification through identificationand

Microbial Taxonomy - Western Washington Universityfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_F07/lect03.pdfMicrobial Taxonomy Traditional taxonomy or the classification through identificationand

Human Evolution - Western Washington Universityfire.biol.wwu.edu/cmoyer/zztemp_fire/biol432_S12/lec15_human_ho.… · of becoming human • We split from most recent living relative

Human Evolution - Western Washington Universityfire.biol.wwu.edu/cmoyer/zztemp_fire/biol432_S12/lec15_human_ho.… · of becoming human • We split from most recent living relative

Teichoic acids and related cell-wall glycopolymers in Gram ...fire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_F10/papers/Weidenmaier_techoic_acids_nat...Teichuronic acid A teichoic acid‑like

Teichoic acids and related cell-wall glycopolymers in Gram ...fire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_F10/papers/Weidenmaier_techoic_acids_nat...Teichuronic acid A teichoic acid‑like

Quantitative Phylogenetic Assessment of Microbial ...fire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_F08/... · most dominant phylum of microbial life in both marine and soil environments

Quantitative Phylogenetic Assessment of Microbial ...fire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_F08/... · most dominant phylum of microbial life in both marine and soil environments

Lecture Series 5 Cell Cycle & Cell Division Reading ...fire.biol.wwu.edu/cmoyer/zztemp_fire/biol205_W14/lect05_n3.pdf · Cell Cycle & Cell Division Reading Assignments ... Mitosis

Lecture Series 5 Cell Cycle & Cell Division Reading ...fire.biol.wwu.edu/cmoyer/zztemp_fire/biol205_W14/lect05_n3.pdf · Cell Cycle & Cell Division Reading Assignments ... Mitosis

BACTERIAL EXAMINATION OF WATER - OpenWebMailfire.biol.wwu.edu/cmoyer/zztemp_fire/biol346_S05/labman... · 2005-03-29 · BACTERIAL EXAMINATION OF WATER ... completed tests (see flow-chart).

BACTERIAL EXAMINATION OF WATER - OpenWebMailfire.biol.wwu.edu/cmoyer/zztemp_fire/biol346_S05/labman... · 2005-03-29 · BACTERIAL EXAMINATION OF WATER ... completed tests (see flow-chart).

Human EvolutionHuman Evolution - OpenWebMailfire.biol.wwu.edu/cmoyer/zztemp_fire/biol432_S13/lec12_human.pdf · Two hypotheses on the origin of modern humans: ... 1997 Cell N E id

Human EvolutionHuman Evolution - OpenWebMailfire.biol.wwu.edu/cmoyer/zztemp_fire/biol432_S13/lec12_human.pdf · Two hypotheses on the origin of modern humans: ... 1997 Cell N E id

Microbial Taxonomy - OpenWebMailfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W07/lect03.pdf · Microbial Taxonomy Traditional taxonomy or the classification through identification

Microbial Taxonomy - OpenWebMailfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W07/lect03.pdf · Microbial Taxonomy Traditional taxonomy or the classification through identification

Lecture Series 9 Cellular Pathways That Harvest Chemical ...fire.biol.wwu.edu/cmoyer/zztemp_fire/biol205_W09/lec09_n3c.pdf · Cellular Pathways That Harvest Chemical ... • Glycolysis

Lecture Series 9 Cellular Pathways That Harvest Chemical ...fire.biol.wwu.edu/cmoyer/zztemp_fire/biol205_W09/lec09_n3c.pdf · Cellular Pathways That Harvest Chemical ... • Glycolysis

What is Microbiology?fire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W10/lect01.pdfFungi heterotrophs; yeasts, molds, mushrooms Protozoa single-celled eukaryotes Nematodes microscopic

What is Microbiology?fire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W10/lect01.pdfFungi heterotrophs; yeasts, molds, mushrooms Protozoa single-celled eukaryotes Nematodes microscopic

Microbial Taxonomy classification identification nomenclaturefire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W06/lect3_3.pdf · 1 Microbial Taxonomy Traditional taxonomy or the classification

Microbial Taxonomy classification identification nomenclaturefire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_W06/lect3_3.pdf · 1 Microbial Taxonomy Traditional taxonomy or the classification