An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR...

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An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department of Neuroimaging and Interventional Radiology National Institute of Mental Health & Neuro Sciences (NIMHANS), Bengaluru-560 029, India. Email: [email protected] For Pharma Graduates & GPAT Aspirants Date: 09/07/2020

Transcript of An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR...

Page 1: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

An Introduction to

Medicinal ChemistryDr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA)Genius Book Record Holder

Postdoctoral Fellow,

Department of Neuroimaging and Interventional Radiology

National Institute of Mental Health & Neuro Sciences (NIMHANS),

Bengaluru-560 029, India.

Email: [email protected]

For Pharma Graduates & GPAT Aspirants

Date: 09/07/2020

Page 2: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department
Page 3: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

Case study:

Page 4: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department
Page 5: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department
Page 6: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department
Page 7: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department
Page 8: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department
Page 9: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department
Page 10: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department
Page 11: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department
Page 12: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

O Oxa

S Thia

N Aza

P Phospha

O > S > N > P

Page 13: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

3 ir (tri)

4 et (tetra)

5 ol (pyrrole)

6 in (pyridine

7 ep (hepta)

8 oc (octa)

9 on (nona)

10 ec (deca)

Ring Size Stem

Page 14: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

ane-saturation & e/ene-unsaturation

Page 15: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department
Page 16: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

Rules:

Rule-1: If the last alphabet follows vowel sound, it must be removed

Rule-2: Use the suffix “idine” only fora) Nitrogen containing b) Fully saturatedc) 3, 4 & 5 HCR

Rule-3: Use the suffix “ine” only fora) Nitrogen containing b) Partial saturatedc) 4 & 5 HCR

Page 17: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department
Page 18: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

3-HCR:

Page 19: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

4-HCR:

Page 20: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

5-HCR:

Page 21: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

5-HCR:

Page 22: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

Case study:

Page 23: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

5-HCR:

Page 24: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

5-HCR:

Page 25: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department

Case study:

Page 26: An Introduction to Medicinal Chemistry · An Introduction to Medicinal Chemistry Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA) Genius Book Record Holder Postdoctoral Fellow, Department