An engineering challenge
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Transcript of An engineering challenge
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An engineering challenge
• I mentioned the engineering problem presented in Apollo 13
• The capsule was filling with the Carbon Dioxide exhaled by the astronauts
• Brainstorm some ideas to help remove the CO2
• What devices would you need?
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An engineering challenge
• Problem 2:• There is a very large mound of soil on one side
of a river. There is no bridge for hundreds of miles.
• Engineers want to move the soil to the other side of the river.
• Brainstorm ideas• What devices would you need
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A synbio design problem
Design bacteria to Nitrates in water and glow green if it is present
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Nitrates sensing device
Reporter Device
Green Glow protein
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Truth Table
Nitrates Present Glow Green 1 1 0 0
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Can you design bacteria that will float and clump in the presence of blue and red light?
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Here are the devices they usedHow would you use them
• Requirements The system requires six biological components.
• Red photosensor • Blue photosensor • AND gate • GFP fluorescent reporter • Promotable surface expression of cadherins • Gas vesicle expression to produce neutrally bouyant
bacteria
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Your design challenge:
• Select an area of focus:– Environment– Health– Food– Manufacturing– Energy
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What particular problem do you want to address?
• Having chosen a general area for your work, now think about any topics in that area you find especially interesting. These could be motivated by an article you've read, a personal experience, a research project you know about. You might want to have a couple of possibilities as you go forward. Remember: this is a brainstorming session. It's a time to keep all ideas that come to mind and then refine or combine them later.
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Can you imagine a biotechnology to address this problem?
• Now let your imagination kick in for a solution to the problems you've brainstormed
• Bacteria too smelly? Make them smell like bananas. • Composting too slow? Make a living additive to accelerate
the process. • Need to fight cavities? Make a yogurt that sticks to your
teeth and heals them. You get the idea.
• You get the idea. Remember that your assignment requires that you think big but stay away from science fiction.
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How will you narrow down your choices?
• You should now have a list of ideas and possible solutions. Deciding between them can be daunting. It might help to compare all your favorite ideas along these five lines: – What precisely is the problem or opportunity you are focusing on? – How clear are you on an approach to make a dent in the problem? – What if your project is fully successful? How big a difference could
it make? What concerns will it raise? – What other technologies can be used/have been used to address
this area? – What don't you know? How big are the gaps in what you know?
How much is completely unknown or unknowable?
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• What precisely is the problem or opportunity you are focusing on?
• How clear are you on an approach to make a dent in the problem?
• What if your project is fully successful? How big a difference could it make? What concerns will it raise?
• What other technologies can be used/have been used to address this area?
• What don't you know? How big are the gaps in what you know? How much is completely unknown or unknowable?
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Your Proposal
• I. Purpose• Describe the problem or challenge you are
trying to solve. • Why is solving this problem or meeting this
challenge important? • What will your design do to address that
problem (overview)?
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Your Proposal
• II. Competing technologies• What technologies are being used to address
this problem at present? • How effective are they?
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Your Proposal
• III. The design• Using both words and diagrams, describe your
design. • What input would the cell be responding to? • How would genetic expression be affected?
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Your Proposal
• IV. Expected results• Using both words and a truth table, explain how
you expect the cell to behave when the design system is working perfectly.
• Using both words and a data table, explain how you expect the cell to behave at a not perfect but acceptable level.
• How will these results bring about a successful solution to the problem?
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Your Proposal
• V. Advantages• How is your biological design an advantage
over the existing technologies? • Why is your design worth funding? (Be
convincing!)
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Your Proposal• VI. Potential problems• What are the potential problems with your system? • What safety features would be required to protect your employees
during development of your design? • How would you protect the environment during development of your
design? • In what ways could evolution of the cells you’ve engineered negatively
affect use of your design in the future? • Are there inefficiencies or shortcomings of your design as compared to
the existing technologies? • Does your design pose dangers to the environment, lab safety, and the
security of the public? • In what ways are the potential rewards worth the risks?
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Your Proposal
• VII. Testing• How would you test the effectiveness of the
system? • (If your design has multiple components, you
may select one component for testing.) • How would testing help improve the system? • How would testing help reveal greater
potential for the system?