Biophysical Journal-An effective solvent theory for osmolytes and denaturants (Supplementary Material)

Biophysical Journal- An effective solvent theory for osmolytes and denaturants (Supplementary Material)

An effective solvent theory connecting the underlying mechanisms of osmolytes and denaturants for protein stability (Supplementary material)

Apichart Linhananta, *,† Shirin Hadizadeh,* Steven S. Plotkin,* *Department of Physics and Astronomy, The University of British Columbia, 6224 Agricultural Road, Vancouver, B.C. V6T 1Z1, Canada; †Permanent Address: Physics Department, Lakehead University, 955 Oliver Road, Thunder Bay, O.N., P7B 5E1, Canada

Address reprint requests and inquiries to Steven S. Plotkin steve@phas.ubc.ca, or Apichart Linhananta apichart.linhananta@lakeheadu.ca

1. SIMULATION MODEL AND METHOD

2. PHASE DIAGRAM IN THE TEMPERATURE, PROTEIN-SOLVENT INTERACTION ENERGY PLANE

3. COMMENTS ON THE SPECIFIC HEAT C* T *( )AND FOLDING COOPERATIVITY

4. ENERGY, ENTROPY, AND FREE ENERGY SURFACES

5. THE CORRESPONDENCE BETWEEN EXPLICIT AND IMPLICIT OSMOLYTE MODELS

6. SOLVATION BARRIERS

7. REFERENCES

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