An Alternative Antidote Therapy in Amitriptyline
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Transcript of An Alternative Antidote Therapy in Amitriptyline
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An alternative antidote therapyin amitriptyline-induced
rat toxicity model: theophylline
Kelompok : 6
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Abstrak
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Pengobatan
standaramitriptyline
• Na2C!
• Norepine"rin
• #opamin
$encegahhipotensi
karena %CA&vasorepress
or'
• (-NA$)• Antagonis A* A2• +intase Nitrat
,nhib• lukagon
•
Aritmia• .ipotensi
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%idak ada terapiantidot yang
spesi/k
• 0eberapa pasienmeninggal
• Kebutuhan untukpilihan obat baru
%eo/lin
1esptorantagonis
adenosin nonselekti"
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Pasien keracunan
amitriptyline tidak selalumerespon pada
penyembuhan standartsehingga terapi 3enis baru
diperlukan
+elain itu studi inibertu3uan untuk
menyelidiki pengaruh dari %heopylin yang
merupakan antagonisnonselekti" reseptor
adenosine sebagai antidotalternati" pada keracunan
amitriptyline
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%ricyclicantidepressants
&%CA
'
adalah salah satupenyebab
keracunan yang
paling seringmuncul di seluruh
dunia
Amitripthylin kardiovaskular-toxic
abnormalitas konduksikardiak &Perpan3angan P1
Pelebaran 41+ danperpan3angan 4%C'
dysrhythmias' dan.ipotensi
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%eo/lin
%heophylin adalah inhibitor tidak selekti" dari phosphodiesterase yangdigunakan dalam asma dan penyakit paru5paru %heophylin memilikibeberapa pengaruh lain sepertiAntagonis nonselekti" reseptor adenosine
Agonis reseptor ryanodine
+ekresi katekolamine
Penyeimbang in"ulks Ca
Antagonisme dari adenosine endogenus menyebabkan meningkatnyalevel cA$P dan kalsium in7uks
$enghambat e"ek adenosine yang berupa vasodilasi koroner inotropisnegative dan chronotropis negative pada isolat 3antung marmut
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$aterial and $ethod
.e8an 93i
• %ikus istar 3antande8asa (n ; 2<'dengan berat 2<=-
2>= g• Percobaan he8an
dilakukan sesuaidengan pedomanyang disediakanoleh (aboratoriumPercobaan .e8an
dan telah disetu3uioleh KomitePera8atan danPenggunaan #oku?.e8an +ekolahKesehatan9niversitas )ylul
0ahan
• 9retan dan @-chloralose
• Amitriptyline
• %eo/lin disiapkandari larutan in"usin3eksi &%eosel ==iv larutan in"ussuntik ==>B >= mgD *== m( teo/lin < gdextrose
monohydrate'
Prosedur
• +etelah prosedurkanulasi selesaihe8an (n ; *6'
dii?inkan untukmenstabilkan diriselama *< menitPada akhir periodestabilisasi dasarpengukuran dicatatdan in"usamitriptyline dimulaidengan dosis =Emg D kg D menit
• %ikus dibagi men3adidua kelompoksecara acak (n ; >untuk setiapkelompok'
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.asil
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Kesimpulan
• Kesimpulan yang didapat dari 3urnal iniadalah dosis * mgDkg in"usi teo/lin e"ekti"dalam membalik hipotensi dan perpan3angan
durasi 41+ pada tikus yang mengalamikeracunan amitriptyline %eo/lin dapatdi3adikan sebagai antidot dalam kasus
keracunan amitriptyline hal ini kemungkinan
disebabkan adanya e"ek antagonisnonselekti" pada asenosine oleh teo/linnamun untuk mengetahui mekanisme harusdilakukan studi lebih lan3ut
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anyou