7/31/2019 An adaptive complex independent component analysis to analyze dynamic contrast enhanced-MRI

http://slidepdf.com/reader/full/an-adaptive-complex-independent-component-analysis-to-analyze-dynamic-contrast 1/4

GK GBGTRO]C LIHTECP OKBCTCKBCKR LIHTIKCKR GKGE_\O\ RI GKGE_VC

B_KGHOL LIKRZG\R CK@GKLCBHZO

 @grcm Hc`zgjogk&7 % Ogk Tgkn 

7 % Zgfo} L`itzg

7gkb Gkkc E+ Hgzrce 

7

7Bctgzrhckr im Hcbolge Joit`y|ol|% Sko}cz|ory im Rizikri% Rizikri% IK% Lgkgbg

GJ\RZGLR

T`gzhgliaokcrol (TA/ hibceokn im rshiz| tzi}obc|okmizhgroik gjisr tczms|oik gkb }g|lsegz tczhcgjoeory im rshiz|+ Obckromyokn gzrczoge oktsr msklroik (GOM/ o| lzsloge ok

TA hibceokn s|okn bykghol likrzg|r ck`gklcb (BLC/HZO+

Gk gbgtro}c lihtecp okbctckbckr lihtikckr gkgey|o|hcr`ib o| bc}ceitcb ri obckromy gkb |ctgzgrc GOM mzihlihtecp BLCHZO bgrg+ R`c zc|ser| gzc lihtgzcb ~or` g

 tzc}ois|ey okrzibslcb GOM c|rohgroik hcr`ib r`gr gtteocbOLG ri hgnkorsbc BLCHZO bgrg+ S|okn |ohsegroik gkb

cptczohckrge t`gkrih |rsboc| or o| |`i~k r`gr s|okn jir`

hgnkorsbc gkb t`g|c bgrg (lihtecp/ zc|ser| ok g hizc

zijs|r gkb hizc gllszgrc GOM hcg|szchckr genizor`h+

 Okbcp Rczh| ‒   Gbgtro}c Lihtecp OLG (GLOLG/%T`gzhgliaokcrol hibceokn% Gzrczoge Oktsr Msklroik (GOM/ 

7+ OKRZIBSLROIK

Gb}gklc| ok isz skbcz|rgkbokn im lgklcz joieiny `g}cckgjecb leokologk| ri rgoeiz rzcgrhckr| ri okbo}obsge tgrockr|+No}ck r`c |tclomolory gkb li|r im r`c|c rzcgrhckr|% tzitcz 

|ceclroik im tgrockr| ~`i ~iseb jckcmor mzih r`c|c

rzcgrhckr| gkb r`c gjoeory ri bcrczhokc rshiz zc|tik|c rirzcgrhckr cgzey o| c||ckroge ri gbfs|r r`c lisz|c im rzcgrhckrQ7X+ Lszzckrey% ohgnokn hcg|szchckr| im rshiz |ovc gkb

c}gesgroik im |czsh hgzacz| gzc r`c r~i hgok gttzigl`c|

s|cb leokolgeey ri g||c|| r`czgtcsrol zc|tik|c+ @i~c}cz%r`c|c lzorczog lgkkir jc s|cb miz gee rshiz| g| ikey g mc~rshiz| tzibslc bcrclrgjec hgzacz| gkb |c}czge hieclsegz 

rgzncrcb gnckr| zc|ser ok ki |onkomolgkr l`gknc ok rshiz |ovc~`oec |`i~okn ohtzi}cb leokolge isrlihc Q:X+ R`s|% r`czc o||onkomolgkr okrczc|r ok msklroikge ohgnokn rcl`kowsc| |sl` g|

bykghol likrzg|r ck`gklcb (BLC/HZO ri bc}ceit ki}ce

hcrzol|+G BLCHZO |rsby% ~`ol` ok}ie}c| okrzg}ckis|

gbhoko|rzgroik im g likrzg|r gnckr mieei~cb jy zctcgrcbohgnokn ri rzgla or| tg||gnc r`zisn` rshiz }g|lsegrszc okrir`c cprzg}g|lsegz cprzglceesegz |tglc (CC\/% tzi}obc|

okmizhgroik gjisr jeiib }ieshc gkb rshiz holzi}g|lsegz  tczhcgjoeory+ Tgzghcrcz| cprzglrcb s|okn t`gzhgliaokcrol

(TA/ hibceokn mzih BLCHZO |rsboc| `g}c jcck miskb ri jc zcegrcb ri tzinki|rol mglriz| Q<X gkb r`coz ziec okg||c||okn gkrogknoinckol r`czgtoc| o| oklzcg|okn Q2X+

G mskbghckrge |rct ok TA hibceokn o| bcrczhokokn r`c

likrzg|r gnckr liklckrzgroik ok r`c okrzg}g|lsegz |tglc(gzrczoge oktsr msklroik/ Q3X+ R`o| |onkge o| s|sgeey

ok|ctgzgjec mzih r`c CC\ likrzg|r liklckrzgroik bsc ri

 tgzroge }ieshc cmmclr% `crczinckcis| rshiz }g|lsegrszc gkbei~ zc|iesroik im ohgnc| r`gr hgac| mokbokn tszceyokrzg}g|lsegz gzcg| ok r`c rshiz cprzchcey bommolser Q=X+

R`czc o| ki hcr`ib ri bozclrey hcg|szc r`c glrsge

gzrczoge oktsr msklroik (GOM/ ok|obc r`c rshiz ok r`c|c|rsboc|+ Ri c|rohgrc r`c GOM% or o| lihhik ri s|c r`clikrzg|r gnckr liklckrzgroik ok gk gzrczy r`gr o| gkgriholgeey

gbfglckr ri r`c rshiz% g |rgkbgzb GOM Q>X% g titsegroikg}czgncb GOM iz g zcmczcklc ro||sc jg|cb GOM Q0X+ R`czc o| g

kccb miz hizc |it`o|rolgrcb ohgnc tzilc||okn rcl`kowsc| ri

hcg|szc r`c GOM+

Gk OLGjg|cb hcr`ib ~g| bc}ceitcb ri hcg|szc gkb|ctgzgrc GOM ok|obc r`c rshiz Q?X+ Ger`isn` r`c isrtsr im HZ ohgnokn o| g lihtecp}gescb% ok r`o| |rsby (g| o|

lihhik ok hi|r BLCHZO |rsboc|/ ikey r`c hgnkorsbc

bgrg ~g| s|cb gkb r`c t`g|c okmizhgroik ~g| kir sroeovcb+R`o| okrzibslcb g mskbghckrge l`geecknc ok OLG gkgey|o| g|

r`c eokcgz hoprszc g||shtroik r`gr o| lizc ri OLG ~g|}oiegrcb+ R`o| tzijech ~g| gbbzc||cb jy s|okn |`izr cl`irohc (RC/ gkb hokohovokn okrzg}ipce bct`g|okn Q?X+

G hizc cmmclro}c ~gy im gbbzc||okn r`c tzijech im 

okrzg}ipce bct`g|okn o| gkgeyvokn r`c lihtecp bgrg zgr`cz r`gk r`c hgnkorsbc bgrg+ Ok r`o| |rsby g lihtecp OLGgttzigl` r`gr lihteoc| ~or` r`c eokcgz hoprszc g||shtroik

im OLG o| s|cb ri hcg|szc GOM+ G |clikb tzijech o| r`gr r`c

l`iolc im li|r msklroik ok OLG }gzoc| g| r`c |iszlc| hgy jc|stczngs||ogk iz |sjngs||ogk gkb ok lg|c im lihtecp|iszlc|% r`cy lgk jc lozlsegz gkb kiklozlsegz+ R`s| s|okn

hcr`ib| r`gr g||shc g mopcb tzijgjoeory bck|ory msklroik(tbm/ miz jir` okrzg}g|lsegz (GOM/ gkb CC\ (g| o| lihhik okleg||ol OLG gttzigl`c|/ Q?X o| kir itrohge+ Gk gbgtro}c tbm 

o| chteiycb ok OLG `czc gkb or| tgzghcrcz| gzc itrohovcb jy tczmizhokn ikeokc bck|ory c|rohgroik gr cgl` orczgroik+

\ohsegroik gkb cptczohckrge ro||sc hoholaokn t`gkrih

|rsboc| gzc likbslrcb ri bchik|rzgrc r`c tczmizhgklc im lihtecp OLG ~or` gk gbgtro}c tbm (GLOLG/ lihtgzcb rir`c tzc}ois|ey okrzibslcb hgnkorsbc OLG (OLG gtteocb ri

hgnkorsbc bgrg ok BLCHZO/ ~or` g mopcb li|r msklroik+

:+ R@CIZ_ GKB HCR@IB\ :+7+ Lihtecp OLG ~or` gbgtro}c kikeokcgzory 

Okbctckbckr lihtikckr gkgey|o| (OLG/ o| g |rgro|rolge |onkge

 tzilc||okn gttzigl` r`gr goh| ri cprzglr skbczeyokn mcgrszc|

im r`c bgrg|cr (skij|cz}cb lihtikckr| iz |iszlc |onkge|/mzih ij|cz}cb hoprszc| |sl` r`gr r`c cprzglrcb mcgrszc| gzc

743:?>0(7(23>>(7030(0)7:)":=+44 :47: OCCC O\JO :47:

7/31/2019 An adaptive complex independent component analysis to analyze dynamic contrast enhanced-MRI

http://slidepdf.com/reader/full/an-adaptive-complex-independent-component-analysis-to-analyze-dynamic-contrast 2/4

hsrsgeey okbctckbckr% ~or`isr g||shokn gky aki~ecbnc im 

r`c hopokn licmmolockr| Q74X+ R`c eokcgz hoprszc OLG hibce

o| cptzc||cb g| % ~`czc ሻଳǧ ଽǧ ǣ ǧ ሹ r`c

BLCHZO bgrg|cr (ij|cz}cb hoprszc|/% ሻଳǧ ଽǧ ǣ ǧ ୗሹ o| g hgrzop likrgokokn r`c H |rzslrszc| r`gr gzc aki~k g|

okbctckbckr lihtikckr| iz OL| ሶ ൗ ሱ gkb

Կീୗ o| r`c hopokn hgrzop+ R`c goh im OLG o| ri

c|rohgrc r`c okbctckbckr lihtikckr| \ gkb r`c hopoknhgrzop G `g}okn r`c ij|cz}cb hoprszc |onkge| V+ Leg||olge

OLG genizor`h| rzy ri mokb gk skhopokn hgrzop Կୗീ 

gkb c|rohgrc r`c OL hgrzop ሻଳǧ ଽǧ ǣ ǧ ୗሹ |sl` r`gr

_ ~`czc zi~| im _ gzc |rgro|rolgeey okbctckbckr+ R`cOL‟| lgk jc zcli}czcb st ri |lgeokn gkb tczhsrgroik Q77X+

Jg|cb ik r`c lckrzge eohor r`cizch% r`c bo|rzojsroik im g

|sh im okbctckbckr zgkbih }gzogjec| rckb| ri~gzb| gNgs||ogk bo|rzojsroik Q7:X+ R`s|% ri mokb r`c okbctckbckrlihtikckr|% ikc `g| ri hgpohovc r`c kikNgs||ogkory im 

r`c cprzglrcb lihtikckr|+ Or ~g| |`i~k r`gr r`c tzijech im hgpohovokn kikngs||ogkory rzgk|egrc| okri r`c mieei~okn

Q7<X6

௪௬௮ ԧ௦ԧଳ ስȇ ሶ ሱȇଽሸ൙  (7/

~`czc o| `czhorogk rzgk|mizh% o| r`c

lihtecp bgrg gkb ሶ ሱ ൡ ሶ ǧ ሱ൩ ~`czc o| r`c

 fiokr tzijgjoeory bo|rzojsroik im  ǧ + R`c mopcb tiokr

stbgrc miz bczo}cb mzih g wsg|oKc~rik gttzigl` o| Q72X6

ଳ ቂ ሶ ሱ ᇷൡ௦൩ ቃ  ስ ᇷሶ ሱ ᇷ ሶ ሱሸ   ስ ሸ ስ ሶ ሱ ᇷᇷሶ ሱሸ  

(:/

R`c gbgtro}c kikeokcgzory ~g| l`i|ck jg|cb ik r`c mglrr`gr nckczgeovcb kizhge bo|rzojsroik| (</ li}cz g ~obc zgknc

im |yhhcrzol bo|rzojsroik| (|sjNgs||ogk miz 5: gkb |stcz

Ngs||ogk miz  ൔ Ͳ/ +

ሶ ሱ Ͳ ሶͼ ሱ ቍ ȇ ȇఏఏ   (</

R`c r~i tgzghcrcz| im r`o| tbm ~czc lgelsegrcb jy mokbokn

r`c hgpohsh eoaceo`iib c|rohgrc miz 6

ቍ ό ȇ ȇఏଳ ଳ ఏ

  (2/

~`czc o| r`c r`c kshjcz im cechckr| im gkb gtteyokn r`c

skor }gzogklc likboroik miz |iszlc| ok OLG Q73X

ስଽ

ሸ භଽ

ሶ ሱ

ଲ 

ଽ ሶͳ ሱሶͼ ሱ ͼ (3/

\rgzrokn ~or` gk okoroge nsc|| miz t% r`c r~i tgzghcrcz| gzc

c|rohgrcb jy orczgro}cey itrohovokn (2/ gkb (3/ gkb msklroik

ሶǢ ሱ o| bczo}cb g|6 ሶ ሱ ൡ ሶ ǧ ሱ൩ ቄ௨ቇఏ

 

:+: \ohsegroik \rsby

G |ohsegroik |rsby ~g| bc}ceitcb ri |ohsegrc BLCHZO

bgrg im g ecgay t`gkrih (kcpr |clroik/ s|okn g lihjokgroikim mokorc cechckr gkgey|o| (MCG/ gkb leg||olge bc|lzotroik im 

HZO t`y|ol| jy hcgk| im Jeil` cwsgroik|+ R`c |ohsegroik t`gkrih ncihcrzy gkb hgrczoge tzitczroc|% or| HZO

glwso|oroik tgzghcrcz| gkb r`c liklckrzgroik im likrzg|r

gnckr ok|obc rsjc| ~czc l`i|ck ri jc lei|c ri r`i|c s|cb okr`c t`y|olge t`gkrih |rsby ok izbcz ri ckgjec lihtgzo|ik+

R`c MCG ~g| s|cb ri hibce bomms|oik im likrzg|r gnckr

mzih r`c okrzg}g|lsegz |tglc (rsjc|/ ri cprzg}g|lsegz |tglc(nce/% g| g jies| im likrzg|r gnckr tg||c| r`zisn` r`c rsjc|+

R`c Jeil` cwsgroik |ohsegroik ~g| tczmizhcb miz cgl`}ipce ri nckczgrc or| HZ |onkge s|okn r`c likrzg|r gnckrliklckrzgroik% r`c hgrczoge tzitczroc| gkb HZO glwso|oroik

 tgzghcrcz| jg|cb ik r`c genizor`h tzc|ckrcb ok r`c \OHZO

 tzifclr Q7=X+ Or ~g| g||shcb r`czc gzc : |tok o|il`zihgrc| okc}czy }ipce lizzc|tikbokn ri ~grcz gkb nce ri geei~

okrzg}ipce bct`g|okn+ R`s|% r`c Jeil` cwsgroik ~g| |ie}cbr~olc miz cgl` }ipce gkb r`c ~grcz)nce likrckr im cgl` }ipcegkb r`coz likrzg|r liklckrzgroik ~czc bczo}cb mzih MC

gkgey|o|+ R`c t`gkrih lik|o|rcb im g nzob im 2Þ2 ecgayrsjc| (okrczkge boghcrcz im :44εh gkb lckrcz ri lckrcz 

|tglokn im 244εh/ r`isn` ~`ol` ~grcz mei~cb ~or` g

lik|rgkr zgrc% chjcbbcb ok gngz nce (ohgnokn tgzghcrcz|gkb t`gkrih |tclomolgroik cptegokcb ok |clroik :+</+

Bykghol likrzg|rck`gklcb ohgnc |ohsegroik ~g| tczmizhcb skbcz J4 hgnkcrol moceb im 7+3R ~or` 7tthok`ihinckcory s|okn g |oknec lioe ZM tse|c+ :B \TNZ 

glwso|oroik im ?4 mzghc| (rchtizge zc|iesroik 8 <+<|/ ~czc|ohsegrcb+ R`c |ohsegrcb BLCHZO bgrg ~g| zclik|rzslrcbok misz bommczckr zc|iesroik| ri `on`eon`r r`c tczmizhgklc im 

r`c tziti|cb GOM hcg|szchckr rcl`kowsc (GL OLG/lihtgzcb ri hgnkorsbc OLG (HgnOLG/+ R`cy ge|i

bchik|rzgrc r`c zijs|rkc|| im r`c OLG rcl`kowsc ok|ctgzgrokn GOM ok bommczckr zc|iesroik|% tgzrolsegzey ok ei~zc|iesroik| r`gr gzc hizc lihhikey ckliskrczcb ok leokolgerzoge|+ R`c `on` zc|iesroik bgrg|cr `g| oktegkc zc|iesroik im 

734εh% ok ir`cz bgrg|cr| `on` mzcwsckly cechckr| gzczchi}cb gkb r`c ei~ zc|iesroik bgrg|cr| `g}c oktgkc

zc|iesroik im <44εh% =44εh gkb 044εh+ G |ghtec mzghc im cgl` bgrg|cr o| |`i~k ok monszc 7+ 

:+< Ro||sc Hoholaokn T`gkrih

G t`y|olge t`gkrih ~g| lik|rzslrcb r`gr lik|o|rcb im g

l`ghjcz im gngz nce (4+3 ~r#% \onhgGebzol` Lgkgbg Erb+%

Lgkgbg/ s|cb g| ro||sc hoholaokn hgrczoge% r`zisn ~`ol`g nzob im 74Þ74 bogey|o| rsjokn (Bogtc| TC\734% Jgprcz% OB

8 :44εh% ~gee r`olakc|| 8 <4εh/ ~or` lckrcz ri lckrcz |tglokn im <44εh jcr~cck r`c rsjc|+ R`c|c rsjc| tgr`r`zisn` r`c gngz nce tgzgeece ri cgl` ir`cz gkb zctzc|ckr r`c

holzi}c||ce|+ R`cy gttzipohgrc r`c boghcrcz im |hgeegzrczoc| iz egznc gzrczoiec|+ R`c|c tizis| rsjc| (tizc |ovc im 

0?kh ri ?>:kh/ geei~ ei~hieclsegz ~con`r likrzg|r gnckrri mzccey bomms|c mzih r`c rsjc| okri r`c nce+

743<

7/31/2019 An adaptive complex independent component analysis to analyze dynamic contrast enhanced-MRI

http://slidepdf.com/reader/full/an-adaptive-complex-independent-component-analysis-to-analyze-dynamic-contrast 3/4

 (g/ (j/ (l/ (b/

Monszc 7 G |ghtec mzghc im r`c r`zcc bgrg|cr|% oktegkc zc|iesroik

im g/ 734εh%  j/ <44εh l/ =44εh gkb b/ 044εh+ 

Bykghol likrzg|rck`gklcb ohgnokn ~g| tczmizhcb

s|okn g :B m\TNZ glwso|oroik (RZ 8 7:+3 h|% RC 8 :+? h|%Meot Gknec8 :4% J^8 73+=< a@v% Kp)Ky)KCP 8 :3=):3=)7%

MI] 8 23 hh% \eolc R`olakc|| 8 3 hh/ ~`czc ?4 ohgnc|~czc glwsozcb i}cz gjisr 2+0 hoksrc| ~or` g rchtizgezc|iesroik im <+< | gkb ki bcegy jcr~cck glwso|oroik|+ R`cbgrg ~g| zclik|rzslrcb ok r~i bommczckr zc|iesroik|6 `on`

zc|iesroik bgrg ~or` oktegkc zc|iesroik im 7>4εh gkb ei~

zc|iesroik ~or` oktegkc zc|iesroik im >44εh+ G |ghtecmzghc im cgl` bgrg|cr o| |`i~k ok monszc :j gkb :l+

(g/ (j/ (l/

Monszc : g/ r`c t`y|olge t`gkrih+ Ohgnokn o| tczmizhcb glzi|| r`c

bg|`cb eokc ok r`c hobbec im r`c t`gkrih% ok g tegkc tcztckbolsegz 

ri }oc~ r`gr o| |`i~k `czc+ g |ghtec mzghc im j/ `on` zc|iesroik

gkb l/ ei~ zc|iesroik BLCHZO bgrg im cptczohckrge t`gkrih+

<+ ZC\SER\

<+7 \ohsegroik T`gkrih |rsby

R`c gbgtro}c lihtecp OLG g| ~cee g| hgnkorsbc OLGokrzibslcb ok Q?X ~czc gtteocb ri gee misz |ohsegrcb bgrg|cr|

gkb r`c |onkge mzih ok|obc r`c rsjc| (GOM/ ~g| cprzglrcb+

R`c GOM lihtikckr ohgnc| miz gee bgrg|cr| gzc |`i~k okmonszc <g% <j% <l gkb <b gkb r`coz lizzc|tikbokn okrck|ory

rohc lsz}c| g| ~cee g| r`c glrsge GOM lsz}c gzc |`i~k okmonszc <c+ G| r`c glrsge ghteorsbc im r`c GOM okrck|oryrohclsz}c o| kir zcwsozcb ok r`c TA hibce| gkb r`cy ikey s|c

r`coz zcegro}c }gesc|% r`c okrck|oryrohc lsz}c| gzckizhgeovcb ~or` zc|tclr ri r`coz hgpohsh gkb r`c tzclikrzg|r liklckrzgroik| gzc lizzclrcb miz ok izbcz ri ckgjec

lihtgzo|ik+ Ok monszc 2 r`c cprzglrcb GOM OL‟| gkb r`coz lizzc|tikbokn okrck|oryrohc lsz}c| miz gee misz |ohsegrcb

bgrg|cr| gkb r`c izonokge GOM lsz}c gzc |`i~k miz HgnOLG+Mo}c BLCHZO bgrg im r`c |ohsegroik t`gkrih ~or`

\KZ8:4 ~g| nckczgrcb+ R`c gkgey|o| ~g| tczmizhcb ~or` jir` OLG genizor`h| gkb ok gee 2 zc|iesroik|+ Rgjec 7 zctizr|

r`c hcgk |wsgzcb czziz (H\C/ jcr~cck r`c c|rohgrcb GOMlsz}c| gkb r`c glrsge lsz}c miz gee 2 bgrg|cr| s|okn jir` OLG

genizor`h|+ Rgjec 7 ge|i zctizr| r`c lizzcegroik licmmolockr jcr~cck r c c|rohgrcb gkb glrsge lsz}c|+

<+: Cptczohckrge T`gkrih \rsby

R`c gbgtro}c lihtecp OLG gkb hgnkorsbc OLG ~czc ge|i

gtteocb ri BLCHZO ohgnc| im r`c ro||sc hoholaokn

 t`gkrih+ Tzceohokgzy zc|ser| im gtteyokn r`c r~i OLGgenizor`h| ri r`c cptczohckrge t`gkrih bgrg o| bctolrcb ok

monszc 3g gkb 3j+ R`c|c monszc| |`i~ r`c GOM lsz}c|c|rohgrcb ok jir` bgrg|cr| jy r`c r~i genizor`h|+

Rgjec 7 hcgk |wsgzcb czziz (H\C/ gkb lizzcegroik licmmolockr

 jcr~cck r`c c|rohgrcb GOM lsz}c| gkb r`c glrsge lsz}c miz 2

bgrg|cr ok jir` OLG genizor`h|

Oktegkc

Zc|iesroik734εh <44εh =44εh 044εh 

Hcgk \wsgzcb Czziz

GLOLG 4+4:3·4+447 4+4<·4+443 4+42>·4+47 4+40>·4+43

Hgn OLG 4+43?·4+447 4+4?·4+447 4+:7·4+44= 4+:>·4+44:

Lizzcegroik Licmmolockr

GLOLG 4+??3 4+??2 4+?0? 4+?>:

HgnOLG 4+??: 4+?0 4+0>> 4+04:

(g/ (j/ (l/ (b/

(c/  

Monszc < GOM r`gr zc|sercb mzih gtteyokn gbgtro}c lihtecp OLG

ri r`c 2 bgrg|cr|6 oktgkc zc|iesroik im g/ 734εh% j/ <44εh% l/

=44εh% b/ 044εh+ c/ GOM lsz}c| lizzc|tikbokn ri r`c 2 bgrg|cr|+

(g/ (j/ (l/ (b/

(c/  Monszc 2 GOM r`gr zc|sercb mzih gtteyokn hgnkorsbc OLG ri r`c 2

bgrg|cr|6 oktgkc zc|iesroik im g/ 734εh% j/ <44εh% l/ =44εh% b/

044εh+ c/ GOM lsz}c lizzc|tikbokn ri r`c 2 bgrg|cr|+

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7/31/2019 An adaptive complex independent component analysis to analyze dynamic contrast enhanced-MRI

http://slidepdf.com/reader/full/an-adaptive-complex-independent-component-analysis-to-analyze-dynamic-contrast 4/4

2+ BO\LS\\OIK\

G |ohsegroik |rsby gkb gk cptczohckrge t`gkrih |rsby ~czc

likbslrcb ri g||c|| r`c mcg|ojoeory im obckromyokn gkb|ctgzgrokn GOM (rsjc|/ ok BLCHZO s|okn OLG+ Gk gbgtro}clihtecp OLG gttzigl` ~g| s|cb `czc gkb ~g| lihtgzcb ri

hgnkorsbc OLG gttzigl` r`gr ~g| tzc}ois|ey okrzibslcb+Jir` cptczohckrge gkb |ohsegroik bgrg ~`czc zclik|rzslrcb

ok bommczckr zc|iesroik| ri g||c|| r`c zijs|rkc|| im r`chcr`ib gkb or| lgtgjoeory ok |ctgzgrokn GOM ok ei~zc|iesroik bgrg r`gr gzc hizc lihhik ok leokolge tzglrolc+

(g/  (j/ Monszc 3 R`c GOM |ctgzgrcb jy gtteyokn g/ GLOLG gkb j/ Hgn

OLG ri jir` bgrg|cr|

G| |`i~k ok monszc <c% 2c% 3l gkb 3b gkb rgjec 7% jir`OLG hcr`ib| ~czc lgtgjec im |ctgzgrokn GOM ~or` `on`gllszgly miz `on` zc|iesroik bgrg+ @i~c}cz% GLOLG

bchik|rzgrcb `on`cz gllszgly gkb zijs|rkc|| lihtgzcb ri

hgnkorsbc OLG g| r`c zc|iesroik im bgrg ~g| zcbslcb+R`czc gzc r~i zcg|ik| miz |stczoiz tczmizhgklc im GL

OLG6 7/ r`c OLG li|r msklroik o| gbgtrcb gr c}czy orczgroik ri

hgrl` r`c tbm im r`c |iszlc |onkge% :/ skeoac r`c HgnOLG%r`c eokcgz hoprszc g||shtroik im OLG o| kir }oiegrcb ok GL

OLG gkb r`s| okrzg}ipce bct`g|okn (|tok| ok|obc cgl` }ipce

gzc kir kclc||gzoey okt`g|c/ gkb tgzroge }ieshc cmmclr bikir tegy g| |onkomolgkr ziec g| r`cy bi ok HgnOLG+

Or ~g| ge|i |`i~k r`gr ger`isn` r`c rsjc| ~czc kir

}o|ojec ok r`c OL ohgnc| im ei~ zc|iesroik bgrg|cr| (jir`|ohsegroik gkb cptczohckr/% r`c GOM lsz}c| ok ei~

zc|iesroik bgrg|cr| gzc }czy lei|c ri r`c `on` zc|iesroik ikc|+R`o| bchik|rzgrc| r`gr OLG jg|cb GOM hcg|szchckr `g| r`c tirckroge ri jc s|cb ok leokolge |rsboc|% ~`czc r`c zc|iesroik

im BLCHZO bgrg o| }czy ei~+

3+ LIKLES\OIK\

Hcg|szokn rshiz |ovc gkb hcg|szokn |czsh hgzacz| gzc kircmmolockr lzorczog ok g||c||okn rshiz zc|tik|c ri r`czgty

 tgzrolsegzey ok gkrogknoinckol r`czgtoc|+ TA gkgey|o| im 

BLCHZ ohgnc| im r`c rshiz tzi}obc| s|cmse okmizhgroik|sl` g| }g|lsegz tczhcgjoeory gkb jeiib }ieshc+ Hcg|szokn

GOM o| g mskbghckrge |rct ok TA gkgey|o|+

Gk gbgtro}c lihtecp OLG hcr`ib ~g| okrzibslcb ri|ctgzgrc GOM mzih bgrg gkb ~g| lihtgzcb ri tzc}ois|ey

okrzibslcb hgnkorsbc OLG+ \ohsegroik gkb cptczohckrge|rsboc| ~czc likbslrcb gkb GOM ~g| cprzglrcb ~or` niib

gllszgly+ Ger`isn` r`c rsjc| ~czc kir }o|ojec ok OL ohgnc|

miz ei~ zc|iesroik bgrg|cr|% r`c GOM lsz}c| ok jir`|ohsegroik gkb cptczohckrge |rsby bchik|rzgrcb r`gr GL

OLG `g| |stczoiz tczmizhgklc gkb |`i~cb `on`cz |rgjoeoryok bcgeokn ~or` ei~ zc|iesroik bgrg|cr| lihtgzcb ri

hgnkorsbc OLG+ R`s|% GLOLG `g| r`c tirckroge ri jc s|cbmiz GOM hcg|szchckr ok TA gkgey|o| im rshiz| ik leokolge

|rsboc| r`gr `g}c }czy ei~ zc|iesroik+

=+ ZCMCZCKLC\Q7X @+L+ Ecc% cr ge+ ―@ctgrol rshiz zc|tik|c c}gesgroik jy HZO‘+

 KHZ Joihcb :26>:7><<% :477+

Q:X G+ Mizkcz%cr ge+ ―

C}gesgroik im rshiz zc|tik|c gmrcz eilizcnoikge r`czgtoc| ok `ctgrilceesegz lgzlokihg6 Gzc zc|tik|c

c}gesgroik lzorczog ok |ieob rshiz| zceogjec9‘ Lgklcz 7736=7==:<

:44?+

Q<X H+ Agkchgr|s% cr ge+  ―Cptzc||oik im }g|lsegz ckbir`ceoge

nzi~r` mglriz ok `ctgrilceesegz lgzlokihg gkb r`c |szziskbokn

eo}cz gkb lizzcegroik ~or` HZO mokbokn|‘+ Gh F Zickrnckie

70260<:027% :443+

Q2X H+I+ Ecgl`% cr ge+  ―G||c||hckr im gkrogknoinckol gkb

gkro}g|lsegz r`czgtoc| ok cgzey|rgnc leokolge rzoge| s|okn hgnkcrol

zc|ikgklc ohgnokn6 o||sc| gkb zclihhckbgroik|‘ Jzoro|` Fiszkge

im Lgklcz ?:673?? “ 7=74% :443+

Q3X @+E+H+ L`ckn% ―Ok}c|rongroik gkb itrohovgroik im tgzghcrcz 

gllszgly ok bykghol likrzg|rck`gklcb HZO‘ Fiszkge im Hgnkcrol

Zc|ikgklc Ohgnokn :06><=>2<% :440+

Q=X G+ C+ @gk|ck% cr ge+  ―Tgzroge ]ieshc Cmmclr (T]C/ ik r`c

Gzrczoge Oktsr Msklroik (GOM/ ok R7^con`rcb Tczms|oik Ohgnokn

gkb Eohorgroik| im r`c Hseroteolgro}c Zc|lgeokn Gttzigl`‘ Hgn+

Zc|+ Hcb+ =:67433743?% :44?+

Q>X Z+ Eg~glvcla% cr ge+ ―T`gzhgliaokcrol| im Likrzg|r Hcbog ok

@shgk| Hibce ^or` Lozlsegroik% Bo|rzojsroik% gkb Zckge

Cplzcroik‘% Ok}c|r Zgboie 2=63>=303% :477+

Q0X P+ Mgk% cr ge+ ―S|c im g Zcmczcklc Ro||sc gkb Jeiib ]c||ce ri

Hcg|szc r`c Gzrczoge Oktsr Msklroik ok BLCHZO‘ Hgn+ Zc|+ Hcb+

=2670:770:=% :474+

Q?X @+ Hc`zgjogk% cr ge+  ―Gsrihgrol hg|a nckczgroik s|okn

okbctckbckr lihtikckr gkgey|o| ok bykghol likrzg|r ck`gklcb

HZO‘% Tzil+ O\JO% :477+

Q74X T+ Lihik% ―Okbctckbckr lihtikckr gkgey|o|% G kc~

liklctr9‘ \onkge Tzilc|| <=6:0><72% 7??2+

Q77X K+ G+ R`glacz% cr ge+ *]ipce jg|cb gkgey|o| im ro||sc }ieshc

mzih HZO bgrg%* Jz+ F+ Zgboie+% }ie+ >>% :442+

Q7:X G+ Gzgsfi% C+ Nokï ―R`c lckrzge eohor r`cizch miz zcge gkb

Jgkgl` }gescb zgkbih }gzogjec|‘% K_6 ^oecy% 7?04+

Q7<X @+ Hc`zgjogk cr ge+ ―G lik|rzgokcb okbctckbckr lihtikckr

gkgey|o| rcl`kowsc miz gzrczy}cok |ctgzgroik im RTE\H ohgnc| im 

r`c lczcjzge holzi}g|lsegrszc‘ Hcb Ohgnc Gkge+% Ok Tzc|| :477+

Q72X H+ Ki}cy% R+ Gbgeo% ―Lihtecp OLG jy Kcnckrzity

Hgpohovgroik‘ OCCC RKK% ]IE+ 7?% KI+ 2% GTZOE :440+

Q73X H+ Ki}cy% R+ Gbgeo% *Gbgtrgjec Kikeokcgzory miz Lihtecp

Hgpohovgroik im Kikngs||ogkory gkb g MopcbTiokr

Genizor`h%* Hgl`okc Ecgzkokn miz \onkge Tzilc||okn% Tzil+7=r`

OCCC \on+ Tzil+ \ilocry ^iza|`it tt>?02% :44=+ 

Q7=X @+J+ Lgrrok% cr ge+  ―R`c \OHZO tzifclr6 g }cz|groec gkb

okrczglro}c HZO |ohsegriz‘% F Hgn+ Zc|+ 7>< ?>“ 773% :443+

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