Patients firstpatient experiences & collaboration

Joep Rijnierse

Medical Director Amgen Netherlands

AMG-NLD-AMG-171-2015-April-P

Amgen is the first and largest biotech company, developing medicine for patients with high unmet medical need

• Established in 1980, with headquarters in Thousand Oaks, California

• Innovative R&D and innovative production sites, best in class

• Approx. 18.000 employees worldwide

• Active in the US and 46 countries worldwide

“Amgen is determined to unlock the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics”

With 12 products in 4 TA’s and a pipeline of 6 products in 2 additional TA’s, Amgen continues to serve patients

Amgen’s mission is to serve patients

Aspiration Dutch affiliate:

Amgen reliably provides best-in-class innovative and established (bio)pharmaceutical solutions for serious diseases and works closely with healthcare professionals, insurers and government agencies, to

create significant value for patients both now and in the future.

X-functional teamwork * entrepreneurship * compliance

7For Internal Use Only. Amgen Confidential.

Amgen’s Strategic Priorities are centred around delivering of patient value

Deliver outstanding performance DEFEND / GROW

Engage and shape the environment

Deliver patient value

Drive successful launches

Engaged and high performing organization

TRANSFORM

TRANSFORM

LAUNCH / ADVANCE

TRANSFORM

Overall objective of VBHC @ Amgen is to fundamentally change the way we operate in the Health Care Landscape

Amgen’s collaborates with stakeholders in care market

• Development of innovative biotech drugs

• In depth knowledge of Dutch healthcare system and understanding of future trends

• Knowledge of concept of Value Based Health Care

• Network of consultants to develop best value proposition per individual project

• Willingness to collaborate with all care stakeholders

Health Care Provider

Health Insurer

Patient / Insured

Care Insurance Market

Care Buying Market

Care Provider Market

Dutch Health Care Market consists of 3 major players

Amgen solidly anchors VBHC in the Dutch organisation trough instalment of a VBHC Center of Excellence

VBHC Center of Excellence has 3 focus areas:

1. Support Amgen's in-line portfolio• Develop innovative collaboration pilots to add value for players

in health care market

2. Create Access for Amgen's pipeline portfolio• Develop innovative collaboration pilots to add value for players

in health care market

3. Be a Center of Excellence• Organise training on VBHC Amgen staff• Engage with relevant consultants and develop network for

future collaboration

6 pilots in collaboration with stakeholders in health care market & consultants

Value Chain Analysis• Outpatient pharmacists • Best practice sharing• Blue Print of ideal value chain• Patient service & Cost

Containment

Patient Flow Analysis• Big Academic Center• Patient flow for MM• Optimize patient flow • Patient service & Cost

Containment

Patient Flow Analysis• Big Nephrology Center• Patient flow for Dialysis patient• Optimize patient flow • Patient service & Cost

Containment Home Infusion • Oncology centres• Added value of home set-up

vs hospital set-up?• Patient service & Cost

Containment

Patient Outcome measures• Big peripheral haematology

Center• In close collaboration with

patient association• Map out relevant patient

measures for optimal ITP treatment

• Develop optimal patient flow with relevant outcome measures

Patient Outcome Measures• Big Nephrology Center• Patient measures for dialysis• Measure quality

A