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WRITING PROCESS

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ALZHEIMER’S IN THE NOWSAMANTHA GOINS

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WHAT IS THIS DISEASE?

Alzheimer’s is a neur!e"enera#i$e !isease in #he %rain&auses se$ere memr' lss an! inhi%i#s #he a%ili#' (r n(un&#inin") O$er #he 'ears #he &ases ( Alzheimer’s has#ea!il' in&rease!) T!a' #here are a**r+ima#el' ,$e m*e*le in #he -)S su.erin" (rm #his !isease)

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/ETA0AM1LOID PLA2-ES ANDNE-RO3I/RILLAR1 TANGLES

• Primar' mar4ers ( #he !e$el*men# ( Alzheimer’s ha

%een i!en#i,e! as am'li! %e#a *la5ues 6&lum*s7 an!

neur,%rillar' #an"les (rme! %' a%nrmal *r#ein !e*

in #he %rain) These mar4ers ha$e %een sh8n # inhi%

neurns (rm su&&ess(ull' sen!in" ner$e si"nals #hru#he %rain)

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HOW IT OCC-RS

• S&ien#is#s ha$e (un! reasnin" #ha# #he !ama"e # #h

&ause! %' Alzheimer’s !e$el*s alms# a !e&a!e %e(

s'm*#ms %e"in # sh8) The !ama"e seems # %e"i

hi**&am*us9 8hi&h is #he &en#er (r em#in9 memr

#he au#nmi& ner$us s's#em) O$er #he *r&ess ( #h!isease9 #he !ama"e s*rea!s $er #he en#ire %rain) In

la#er s#a"es9 #he %rain has %een (ull' a.e&#e!9 an! in #

sus#aine! si"ni,&an# #issue shrin4a"e)

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GENE PREDISPOSITION

• A "ene 4n8n as a*li*r#ein E 6APOE:7 has %een a;

8i#h la#e0nse# 6a"e <= an! a%$e7 Alzheimer’s) 1u &a

re&ei$e an APOE: "ene (rm ea&h ( 'ur *aren#s) Re&

#his "ene (rm ea&h *aren# *u#s 'u a# a hi"her ris4) T

#here is a lin4 %e#8een #he "ene an! !e$el*men# ( #!isease9 #hese "enes are n# !e,ni#e &auses9 %u# ra#he

(a&#rs)

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S1MPTOMS IN STAGES

•  mil! 6earl'0s#a"e7> &a#e"rize! %' %ein"*rimaril' in!e*en!en#9 lsin" r

mis*la&in" $alua%le %e&#s9 an!!i;&ul#' *lannin" an! r"anizin"

• m!era#e 6mi!!le0s#a"e7> #'*i&all' #he ln"es#9 #he$i&#im is sus&e*#i%le # (rus#ra#in an!an"er9 in&rease! #en!en&' # 8an!er9

&n(usin9 re*e#i#i$eness9 an!im*airmen#s ( reasnin"

• se$ere 6la#e0s#a"e7> n ln"er res*n!in" ##heir en$irnmen#9 re5uire (ull0#ime &are

an! assis#an&e in !ail' a&#i$i#ies

h##*s>@@888)'u#u%e)&m@8a#&h?$mIOB:0&S1

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DIAGNOSIS

Di.eren# #'*es ( #es#s are use! #"e#her # hel*(rm a !ia"nsis9 ea&h ser$in" a *ur*se in #he

*r&ess>

 The Mini Men#al S#a#e E+am 6MMSE7>Assesses man' !i.eren# men#ala%ili#ies ran"in" (rm a##en#in s*an ##he a%ili#' # un!ers#an! ins#ru&#ins) I#

in&lu!es e+er&ises su&h a memrizin"an! re*ea#in" lis#s9 an! 8ri#in""ramma#i&all' &rre&# sen#en&es) I#s*ur*se is # measure #he men#alim*airmen# &rea#e! %' #he !isease

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DIAGNOSIS

CT an! MRI s&ans > rule u##her *ssi%le &auses (s'm*#ms9 su&h as #umrs) The MRI &an als !e#e&#%rain shrin4a"e9 8hi&h has

%een i!en#i,e! as a resul# (Alzheimer’s)

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DIAGNOSIS

EEG> -se(ul %' measurin"%rain a&#i$i#'> M!era#eAlzheimer’s sh8s man'u&#ua#ins an! se$eresh8s minimal a&#i$i#'

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MEDICATIONS@TIPS

 There are n &urren# &ures

Cmmn me!i&a#ins (r #he m!era#e s#a"es ( Alzhare Raza!'ne an! Ari&e*#9 #ha# (un&#in as inhi%i#rs #*r"ressin

Heal#h' Li(es#'le> minimal re,ne! su"ars an! sa#ura#e8a#er &nsum*#in9 !ie# (ull ( ri&h nu#rien#s an!an#i+i!an#s9 *h'si&al an! men#al e+er&ise

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C-RRENT CLINICAL TRIAL

•  The F= Alzheimer’s Ass&ia#in Annual Cn(eren&e &n&lu!e! #ha# a ne8

s#ar#J anal'sis sh8n in #he #rial (r slanezuma%9 a !ru"9 ma' ha$e #he a

sl8 #he *r"ressin r *re$en# #he !isease) I# is *ar# ( #he A: in#erna#in

Si+#' hs*i#als are sear&hin" (r *a#ien#s #ha# sh8 n &urren# mem

%u# #ha# ha$e %rain s&an in!i&a#in" #ha# #he' are sus&e*#i%le # Alzheimer’

(u#ure) Their s&ans ma4e #his *re!e#ermina#in %' re(eren&in" #he %uil!0u*

am'li! %e#a *la5ues) The "al ( #his #rial is (r slanzuma% # !es#r' #h%e(re i# !es#r's #he %rain) Pre$en#in" #he %uil!0u* ( am'li! %e#a *la5u

*re$en# memr' lss) Als #hru"h resear&h9 an#her #+i& *r#ein 4n8n a

similar # am'li! %e#a0*la5ues9 has %een lin4e! # #he !e$el*men# ( Alz

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ALZHEIMER’S ASSOCIATION

A!$an&es resear&h # en! AlzheimerKs an! !emen#ia 8henhan&in" &are (r #hse li$in" 8i#h #he !isease

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