Allicin - Nature’s Antibiotic From the heart of garlic SALISBURY 20 th February 2008.
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Transcript of Allicin - Nature’s Antibiotic From the heart of garlic SALISBURY 20 th February 2008.
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Allicin - Nature’s Allicin - Nature’s AntibioticAntibiotic
From the heart of garlicFrom the heart of garlic
SALISBURY 20th February 2008
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What’s in garlic that makes What’s in garlic that makes it so powerful?it so powerful?
Garlic contains a wide range of vitamins Garlic contains a wide range of vitamins and minerals a sulphur compound and minerals a sulphur compound called “alliin” and an enzyme called called “alliin” and an enzyme called “alliinase”“alliinase”
When harvested garlic has no smell but When harvested garlic has no smell but it contains a very potent defence it contains a very potent defence mechanism that starts when garlic is mechanism that starts when garlic is cut, cooked, boiled, chopped, fried or cut, cooked, boiled, chopped, fried or mechanically processed in any waymechanically processed in any way
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Now for the smelly bit!Now for the smelly bit!
Let’s make some AllicinLet’s make some Allicin
Crush some fresh garlicCrush some fresh garlic
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Allicin produced from fresh Allicin produced from fresh garlicgarlic
ALLIIN
ALLICINALLINASE
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Allicin the “Mother” Allicin the “Mother” substancesubstance
DATS DADS
ALLICIN
AJOENE
THIOSULPHINATE COMPOUNDS FORMED WHEN ALLICIN BREAKS DOWN ARE ALSO BODY ACTIVE
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Historical properties of garlic Historical properties of garlic that that
can be attributed to allicincan be attributed to allicin
Anti-bacterial - wide spectrum of sensitive Anti-bacterial - wide spectrum of sensitive bacteria both gram positive and negativebacteria both gram positive and negative
Anti-viral (including common cold virus)Anti-viral (including common cold virus) Anti-fungal (more effective than many Anti-fungal (more effective than many
drugs)drugs) Anti-cancer (IOWA women’s study)Anti-cancer (IOWA women’s study) Anti-cholesterol (substantial data)Anti-cholesterol (substantial data) Anti-blood pressure (substantial data)Anti-blood pressure (substantial data) May reduce blood sugar levelsMay reduce blood sugar levels May help to reduce fat build up and lead to May help to reduce fat build up and lead to
loss of weightloss of weight
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Types of Garlic Types of Garlic supplementsupplement
Garlic oil capsules – no allicin potentialGarlic oil capsules – no allicin potential Aged garlic extract – no allicin potentialAged garlic extract – no allicin potential Garlic macerates – some allicin potential?Garlic macerates – some allicin potential? Garlic powder – potential depends on Garlic powder – potential depends on
processingprocessing Garlic powder easily inactivated by Garlic powder easily inactivated by
stomach acidstomach acid Allicin powder supplements like Allicin powder supplements like
AllicinMax have now been available for 7 AllicinMax have now been available for 7 yearsyears
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Active supplement Active supplement manufactured by Allicin manufactured by Allicin
International LimitedInternational Limited
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Preventing the Common ColdPreventing the Common Cold
A double blind placebo A double blind placebo controlled survey with 146 controlled survey with 146
volunteersvolunteers
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Antiviral: Antiviral: How “common” is a How “common” is a
cold?cold? In the Western World we see 2-5 In the Western World we see 2-5 coldscolds onon
average per person per yearaverage per person per year Over 200 different cold virus typesOver 200 different cold virus types Viral disease is an excellent travellerViral disease is an excellent traveller The common cold costs National The common cold costs National
economies enormous sums of money in economies enormous sums of money in lost working dayslost working days
Prevention is always better than curePrevention is always better than cure
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ResultsResults
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Active supplement with the Active supplement with the optimum dose of allicin is optimum dose of allicin is
found found ONLY in AllicinMaxONLY in AllicinMax
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Results - Number of coldsResults - Number of colds
24
65
0 20 40 60 80
Active
Placebo
P<0.05
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Results - Average Results - Average symptom duration (days)symptom duration (days)
1.52
5.01
0 1 2 3 4 5 6
Active
Placebo
p<0.001
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Repeat infectionsRepeat infections
2
16
0 5 10 15 20
Active
Placebo
p<0.001
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ConclusionsConclusions
AllicinMax can prevent the Common ColdAllicinMax can prevent the Common Cold Reduction of severity of symptomsReduction of severity of symptoms Re-infection less likely with AllicinMaxRe-infection less likely with AllicinMax Could represent huge savings for the UK Could represent huge savings for the UK
economyeconomy Product is well tolerated and may offer other Product is well tolerated and may offer other
advantages according to volunteer reportsadvantages according to volunteer reports Manufacturer’s recommended dose was Manufacturer’s recommended dose was
usedused Addition of various vitamins or minerals or Addition of various vitamins or minerals or
herbs is a logical combinationherbs is a logical combination
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Allicin as a modern anti-Allicin as a modern anti-bacterialbacterial
Known as “Nature’s antibiotic”Known as “Nature’s antibiotic” Broad spectrum of activityBroad spectrum of activity No resistance has ever been recordedNo resistance has ever been recorded Allicin prevents bacterial enzyme Allicin prevents bacterial enzyme
productionproduction Problem infections can be resolved with Problem infections can be resolved with
allicinallicin Allicin is natural, safe and effective Allicin is natural, safe and effective
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MIC (ppm allicin) for some MIC (ppm allicin) for some problem bacteriaproblem bacteria
Streptococcus pyogenesStreptococcus pyogenes 16 ppm16 ppm Staphylococcus aureusStaphylococcus aureus 16 ppm16 ppm Listeria monocytogenesListeria monocytogenes 16 ppm16 ppm Escherichia coliEscherichia coli 0157 0157
32 ppm32 ppm Salmonella typhimuriumSalmonella typhimurium 32 ppm32 ppm Clostridium perfringensClostridium perfringens 64 ppm64 ppm Helicobacter pyloriHelicobacter pylori 16 ppm16 ppm
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Staphylococcus aureusStaphylococcus aureus
Involved in 95% of simple cases of Involved in 95% of simple cases of eczemaeczema
Leads to worsening of clinical Leads to worsening of clinical symptomssymptoms
Causes secondary infectionCauses secondary infection Prevents topical steroids from workingPrevents topical steroids from working Present in most cases of acnePresent in most cases of acne Prevalant bacterium in psoriasisPrevalant bacterium in psoriasis
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Staphylococcus Staphylococcus aureusaureus - The “Golden” - The “Golden”
BacteriumBacterium
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Where it all Where it all began with began with realreal
patientspatients
Debra’s wounds - open on the right but after treatment on the left both long standing wounds had closed and no further procedures were required
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Human Volunteer Human Volunteer StudiesStudies
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Allicin kills Staph. aureusAllicin kills Staph. aureus
Work completed at The University Work completed at The University of East Londonof East London
30 bacterial strains were tested 12 30 bacterial strains were tested 12 were resistant to pharmaceutical were resistant to pharmaceutical antibioticsantibiotics
ALL strains were sensitive to Allicin ALL strains were sensitive to Allicin Published in June 2004 in The Published in June 2004 in The
Journal of Biomedical ScienceJournal of Biomedical Science
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AllicinMax vs MUPIROCIN AllicinMax vs MUPIROCIN (a pharmaceutical (a pharmaceutical
antibiotic)antibiotic)
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Case history – before Case history – before treatmenttreatment
Female, 14 yrs old 2 pins inserted wounds failed to heal for Female, 14 yrs old 2 pins inserted wounds failed to heal for 18 months. Patient had several courses of antibiotics with 18 months. Patient had several courses of antibiotics with no effect. Surgeons were keen to readmit her and replace no effect. Surgeons were keen to readmit her and replace the pins and deal with the infection. We tested her as +the pins and deal with the infection. We tested her as ++MRSA sensitive to allicin+MRSA sensitive to allicin
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Case history after treatmentCase history after treatment Treatment was 1800 mg of allicin powder daily in divided Treatment was 1800 mg of allicin powder daily in divided
doses (AllicinMAX only) for a period of 4 weeks. No creams doses (AllicinMAX only) for a period of 4 weeks. No creams or spray were needed in this case. Swabs post treatment or spray were needed in this case. Swabs post treatment showed no MRSA infection present in the healed area, groin showed no MRSA infection present in the healed area, groin or nasal cavityor nasal cavity
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What does this mean to What does this mean to patients?patients?
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You get your life back!You get your life back!
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Is allicin really stable?
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Purity of Allicin using HPLCPurity of Allicin using HPLC
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Mass Intensity73 40,128121 54,038163 162,051
100 150 200 250 300 350 400
m/z
100
75
50
25
0
Relative Intensity (%)
73
121
163 (M+H+)
180 (M+NH4+)
Mass Spectrometric Analysis of Allicin
Allicin 1 mg/ml (Lawson)
Allicin (162)
CH2
CHCH2 SCH2
CH S CH2
O
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SummarySummary A unique opportunity to capitalise A unique opportunity to capitalise
on the long established properties on the long established properties of garlic’s active mother substance of garlic’s active mother substance ALLICIN. Only now is this 21ALLICIN. Only now is this 21stst century molecule available in a century molecule available in a form that the human race can form that the human race can really feel the benefit.really feel the benefit.
Antiviral, Antibacterial, Antifungal, Antihistamine
Antiparasite, Anticholesterol, Antihypertensive