1.A need for innovative approaches to pest and disease controlAN SMES PERSPECTIVEDr Alison Blackwell, Advanced Pest Solutions Ltd.

2. THE CHALLENGEPests and diseases are responsible for substantial losses across a range of sectors: Food production Human and animal health Quality of life 3. THE CHALLENGEIncreasing resistance, legislative changes and an increasing consumer need for chemical-free solutions are all hindering effective managementThe challenge to an SME: developing and marketing innovative and sustainable solutions, with often limited budget and resources and against significant competition 4. WHAT DOES APS DO?Develop and delivery innovative technologies and solutions for pest anddisease controlA core scientific team comprising of molecular biologists, bacteriologists,entomologists and ecologistsClose working relationships with key industry partners, allowingtechnology and product development to be focussed where there iscommercial need and applicationFunded through a combination of equity finance, grants and an activerevenue streamKey to success: diversity in technology development and market application 5. WHAT DOES APS DO? Hands-onpestmanagementprogrammes Inesct behavioural modificationtechnologiesNovelantimicrobialtechnologies 6. WHAT DOES APS DO? 7. INSECT PESTS IN THE NEWS 8. INSECT PESTS IN THE NEWS 9. INSECT PESTS IN THE NEWS 10. INSECT PEST CONTROL Habitat manipulation TrapsRepellents Insecticides 11. INSECT PEST CONTROL 12. OPTIONS FOR INSECT REPELLENTS Natural & synthetic Natural: incl. wood smoke & a whole range of essential oils(tea tree, boy myrtle, neem, eucalyptus etc) disadvantages of natural repellents short activity,odour, skin irritation Recent legislation has reduce the number ofapproved actives in the EU to just 4: DEET [synthetic] Picaridn (Saltidin) [synthetic Bayer] IR3535 [synthetic Merck] Oil of Lemon Eucalyptus (PMD) only naturally-derived repellent that can legally make repellentclaims in the EU 13. HOW DO INSECT REPELLENTS WORK? Inhibiting the response to an otherwise attractive signal Switching the sensory message from attraction torepulsion Activating a receptor system that controls a competingbehavior Activating a noxious odor receptor Activating different receptor types simultaneously,resulting in loss of the specific signal for host finding 14. HOW DO INSECT REPELLENTS WORK? 15. APS REPELLENT INNOVATION 16. APS REPELLENT INNOVATION 17. APS REPELLENT INNOVATIONA repellent for midges in Scotland (and biting pests outside of the UK)that would: be effective be safe have a competitive edge over other products On the market repellents lacked personality Either medically-orientated or natural/organic We wanted a different brand for Scotland thatrepresented the fun, outdoor activities peopleare involved in, whilst maintaining a high levelof family-safe repellency 18. APS REPELLENT INNOVATION Launched in 2010 A broad-spectrum repellent suitable for the wholefamily Specifications: A long-lasting (8h+), waterproof skin protectionthat is efficient against all blood-feeding insects,worldwide 19. WHATS IN THE BOTTLE? 20. APS REPELLENT INNOVATION Chemical names: Icaridin (EU, RoW), Picaridin (USA/CAN) Common names: Icaridin, Saltidin, PicaridnSaltidin Saltidin is a safe and reliable active ingredient for insectrepellents, combining widespread effective protection withpleasant cosmetic properties Saltidin is recommended by the World HealthOrganization & many other national health organisations Saltidin is one of only 4 repellent actives that has beenregistered under the EU Biocidal Products Directive, inaddition to registrations in the USA, Brazil, Canada, Asiaand Australia according to EPA Guidelines 21. APS REPELLENT INNOVATIONEfficiency:Saltidin Long lastingBroad spectrum ofinsectsSafety:Compatibility:Non toxicSafe for plasticsNon irritating to skinSafe for Low adsorptioncoatings/sealants Non-sensitising to skinSafe for the environment Cosmetic properties: Discreet scent/odorless Non sticky Pleasant skin feel Non greasy 22. APS REPELLENT INNOVATION 23. APS REPELLENT INNOVATIONSaltidinSaltidinDEETAedes aegyti (Yellow fever) 7.3h (15%) 5.2h (15%)Aedes albopictus (Dengue)6h (20%)4h (20%)Culex spp (West Nile virus)>8h (12%) >8h (17%)Anopheles spp. (Malaria)>8 h (12%) 7h (17%)Biting midges >8h (20%)--Ticks (various) 2-6h (20%) 0.5-4h (20%)Length of protection in hours, and concentration of active 24. APS REPELLENT INNOVATION Smidge: 20% Saltidin solution, in a patented moisturising, water/sweat-proof lotion formulation: Powerful, reliable protection for up to 8 hours againstmidges, mosquitoes and other biting insects 4 hours protection against ticks Water and sweat resistant Pleasant smell & moisturising Safe for use on adults, children over 24 months andpregnant women Safe alternative to DEET Wont melt plastic kit Human-friendly fragrance Scientifically proven in Scotland 25. HOW WELL DOES IT WORK? 26. APS REPELLENT INNOVATION Anopheles stephensi The major vector of malaria in the Middle East & S. Asia 8h protection withall test species 27. APS REPELLENT INNOVATIONThe arms speak for themselvesafter a night in the Highlands ofScotland exposed to biting midges 28. INNOVATION IN PROMOTION 29. INNOVATION IN PROMOTION 30. INNOVATION IN PROMOTIONwww.facebook.com/TheSmidgeForecast 31. INNOVATION IN PROMOTIONwww.twitter.com/midgeforecast 32. INNOVATION IN PROMOTION www.midgeforecast.co.uk 33. INNOVATION IN PROMOTION 34. MIDGE FORECAST141s t June Obs erved Predicted1210 ARMA model including air temperature, rainfall, wind speed & sunlight: 60% of observed variationln(Total + 1) 8 6 Relating midge activity to 4 meteorological factors throughout several midge 2 seasons 0 6/5 20/5 3/6 17/6 1/7 15/729/7 12/8 26/8 9/9 date (day/m onth) 35. MIDGE FORECAST 36. MIDGE FORECAST The forecast output is verified by a network of midge traps, operated by volunteers, weekly from May - September 37. SMIDGE SALES 38. SMIDGE SALES EventsRetailers Online 39. SMIDGE SALESSmidge launched in 46 Scottish Tescostores, 9th May 2012380 UK Smidge retailers to date 40. ACHIEVEMENTS TO DATE 41. APS REPELLENT INNOVATION 25,000 units sold in only the secondseason (2011) & 45,000 target for 2012 Nearly 400 trade outlets Active social media outlets (Facebook& Twitter) Overseas interest (Scandinavia,Australia) & launched into Asia (May2012) Winner of Nexxus Innovation Award2011 Now the best selling repellent inScotlands biggest outdoor retail shop(Tiso) Secured a contract to supply the UKslargest supermarket chain in 2012(Tesco) 42. www.advancedpestsolutions.co.uk