AHA SonyaDoherty Part1

8/6/2019 AHA SonyaDoherty Part1

1/38


2/38


3/38

Why is your child autistic? Can your child be treated? When does the DAN! approach work? Why is autism a biomedical problem? Why is it so difficult to treat? How do you treat autism?


4/38

25% of developmental and neurologicalproblems in children could be caused byenvironmental pollution combined with

genetic predisposition


5/38

Genetics = pre-existing weakness

Environmental stressors


6/38

Environment Heavy Metals, Chemical

Toxicity, Vaccines, Xenobiotics Nutrient Deficiencies or conversion issues

Viruses or viral overload CMV, measles,paramyxoviruses, mumps, streptokinase|

Bacterial Clostridia, Strep

Endocrine thyroid function and adrenals


7/38

exponentially since 1990.

World figures as high as 90 per 10,000.

4:1 male to female ratio

The current prevalence in Canada = 1 in 110

1980 1 in 2500 children were dx with autism

1 in 6 children dx with DEVELOPMENTAL DISORDERS(ADD/ADHD, Tourettes, OCD, learning disabilities )


8/38

1:50 - Brick Township, NJ Toxiclandfill

1000% increase in California in 20years

Increase 100% in last 15 20 years

Why is ASD prevalence increasing?


9/38

Risk 50 times with sibling

375 times with identical twin

Chromosomal abnormalities can be inherited oraltered in utero - Jan. 17th in the American Journal of Human Genetics

The big question: What alters chromosomes?


10/38

LDs

OCD

TS

AD/HD

ASD


11/38


12/38

Serotonin Dopamine

Learning Brain Function

Sleep Processing of info

Memory Sensitivity

Behaviour Perception of change

Noise Sensitivity Relaying info

Appetite Emotional Responses


13/38

FDA and AAP mercury amount given to infants fromvaccines EXCEEDS SAFETY LEVELS (237 mcg)

Children can be exposed in utero to heavy metals chromosomal damage, receptor and NT damage, shutsdown enzymes

250 chemicals in body fat of EVERY PERSON IN THEWORLD

Pesticides found in blood of newborn babies

EPA - 1.16 million women of childbearing age eatenough mercury contaminated fish to do damage afetus


14/38

FDA and AAP mercury amount given to infants fromvaccines EXCEEDS SAFETY LEVELS (237 mcg)

Children can be exposed in utero to heavy metals chromosomal damage, receptor and NT damage, shutsdown enzymes

250 chemicals in body fat of EVERY PERSON IN THEWORLD

Pesticides found in blood of newborn babies

EPA - 1.16 million women of childbearing age eatenough mercury contaminated fish to do damage afetus


15/38

Neuropsychobiology 1996 Geneticsusceptibility in immune system infection atcritical time triggers autism

CDC confidential report on study linking autismand vaccines resulted in lawsuit filed by 5000families

Infants exposed to more that 62.5 mcg of mercury in first 3 months of life were 2.48

times more likely to develop autism


16/38

All Reporting Facilities, All Chemicals TRI-(1987-2002) Map shows 3,683 of 48,205 facilities reportingnationwide Total toxicity

Autism rates

Chemicals-TRI(Toxic Release

Inventory)


17/38

Digestion Sleep melatonin, sedative botanicals

Eczema - EFAs Headaches food allergies

Anxiety methylation! Depression methylation!


18/38

Evidence based medicine? Studying one thing at a time doesnt work forcomplex disorders

Flood analogy: cause vs. damage caused In 1960 we knew folic acid prevented birth

defects 2009 dose = 3-5 mg B12 needed to optimize folic acid still have notlearned from known biochemistry 5-MTHF

Research has limitations but is important WE KNOW HOW TO HELP CHILDREN NOW!


19/38

Oxidative stress

Toxins and infectious agents Dysfunctional detox capacity Altered insulin response need sugar to digest Serotonin and dopamine dysregulation GABA and glutamate imbalance Immune dysregulation

Essential fatty acid deficiency Zinc / copper imbalances Amino acid deficiencies Altered enzyme function MTR and CBS Persistent inflammation = brain allergy (TNF,

IL-6, IL-1) GSH oxidative stress, inflammation and detox


20/38

Dr. Jill James, PhD methylation, glutathione

Hannah Poling Mitochondrial defects

Dr. Judy Van de Water antibodies against fetalbrain cells, monkey study

Dr. McFabe clostridia

Dr. Martha Herbert brain is swollen, oxidativestress

Dr. Vargas persistent brain inflammation


21/38

Dr. Singh autoimmune hypothesis

"In 1993 Dr. Singh, PhD found antibodies tomyelin basic protein in 50 to 60% ASD kids

Another study of 27 found nearly 50% correlationbetween MMR antibodies and antibodies to myelin

basic protein in serum

Auto-antibodies to neuron-axon filament protein(anti-NAFP) and glial fibrillary acidic protein (anti-GFAP) were significantly higher [anti-NAFP (P = .004)] and [anti-GFAP (P = .002)] in autisticsubjects, but not in MR subjects


22/38

Dr. Needleman lead

Dr. Shaw yeast

Texas Studies environmental toxicity

Dr. Wakefield and Dr. Krigsman inflammatory bowel

Dr. Richard Deth methyl and cognition


23/38

Top two risk factors are pre-natal viralinfection and a parent with anxiety and/ordepression (methylation!)

Family history of autoimmune disorders,genetic dysfunction in detoxification and/or gene-related vitamin, antioxidant andother deficiencies


24/38

In case-control analysis, a significant increase inthe reduced folate carrier (RFC1) G allelefrequency was found among case mothers, butnot among fathers or affected children

Maternal G allele was associated with significantincrease in risk of autism whereas the inheritedgenotype of the child was not Further, maternalDNA from the autism mothers was found to besignificantly hypomethylated relative to referencecontrol DNA


25/38

Obstetrical complications associated with highrisk of developmental disorder

Prematurity (before 36 weeks)

Low birth weight (less than 2500 grams)

Respiratory Distress Syndrome

Rhesus Incompatibility (Rhogam)

C-sectionResuscitation

Severe fetal / neonatal infection

Hemolytic anemia / transfusion for anemia

Severe birth trauma


26/38

Maternal risk factors for low birth weight

infantPreeclampsia (homocysteine elevation risk factor methylation!)

Nutrient deficiencies

Iron deficiency

Nausea / Vomiting B6 deficiency?

Thyroid dysfunction subclinical hypothyroidism

Folate handling


27/38

European and North American populations, have shownthat omega-3 fatty acids, whether from dietary sources orother supplementation, cause a significant increase in theduration of pregnancy

Most significant predictor of infant health is age at birth Essential fatty acid deficiency is a risk factor for preterm

labour, prolonged labour and labour complications

EFA deficiency is also a risk factor for developmentaldisorders

Preterm Labour is a risk factor for autism and otherdevelopmental disorders

Essential fatty acids decreases risk of preterm labour


28/38

Would you be interested in a drug for ASD that?

Regulate immunity protect againstautoimmunity

Protect against infection Clostridia, Yeast andStrep

Detoxify metals and harmful chemicals Absorb and synthesize nutrients including

essential fatty acids and zinc Decrease inflammation Increase energy Increase serotonin by 95% Increase neurotransmitter production dopamine


29/38


30/38

Serotonin Dopamine

95% gut Lipid peroxidation and oxidativestress inhibits breakdown

Gut: DPPIV enzyme deficiency,yeast, clostridia, strep = impaired protein breakdown

Gut absorption of co-factors thatmake dopmaine

Methylation Defects Methylation Defects

Transulfation Impairment Transulfation Impairment


31/38

Glutamate is converted to GABA B6

Gut issues impair conversion causing hyperexcitability YEAST BINDS B6

Self stimulating behaviour Hyperactivity Difficulty learning, processing and focusing Impulsivity Impaired development


32/38

The National Institute of Health has begun to

sequence the microbial environment of the gut

Postnatal development Integral part of human genetic landscape and evolution Production of essential vitamins and xenobiotic metabolism Provide and balance energy balances Microbes manipulate host genes resulting in alterations in

the deposition of energy into different sites Gut epithelial renewal rates The composition of the gut microbiome is affected by or

affects obesity


33/38

40 85% of children with ASD suffer from

chronic digestive issues including: Constipation Diarrhea Bloating

Pain Mucous and undigested food

*Up to 95% of serotonin is located in the gut*


34/38

Vaginal Birth there is a reason we are bornface down in poop (transfer of MICROBIOME)

Breastfeeding

Early weaning of piglets reduced the level

and performance of enzymes (includingalkaline phosphatase) in the gut, which leadsto decreased growth development andillness

~Dale Lackeyram, a PhD

University of Guelph


35/38

Alkaline phosphatase has two major

implications:1. Making phosphorus available for bone growth and

development2. Alkaline phosphatase is part of the bodys natural

defence system

This enzyme is capable of acting on the toxiccomponents of bacterial cells such as E. coli


36/38

Formula fed piglets have stunted villi

Breastfed children have lower rates of ASD, ADHD and learning disabilities

Why isnt there more support for BF? Why do we know more about piglets than

we do about our children?


37/38

Yeast Clostridia Streptococcus Genes and Environmental Stressors Environmental Toxicity Methylation and Inflammation Inflammation in the brain Physical Issues Gut is the strongest leverage point Imbalanced microbiome and leaky gut Mitochondrial defects Detoxification impairment Immune dysfunction


38/38

AHA SonyaDoherty Part1

Documents

Transcript of AHA SonyaDoherty Part1