Ageing Brain, environmental factors and metabolism
description
Transcript of Ageing Brain, environmental factors and metabolism
![Page 1: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/1.jpg)
Ageing Brain, environmental factors and metabolism
Based on the Nature review: Recruiting adaptive cellular stress responses for successful brain ageingBy Alexis M. Stranahan & Mark P. Mattson
![Page 2: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/2.jpg)
Brain structures highly affected by oxidative stress
![Page 3: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/3.jpg)
Neurodegenerative disorders have a logarithmic increase in prevalence with
respect to aging
![Page 4: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/4.jpg)
The Selective neural vulnerability phenomena is based on
morphological
-high energy requirements -reliance on axonal support for sustained function - large cell area.- High numbers of AMPA and NMDA receptors.- Low levels of Calcium binding proteins- Dysfunction and death of neurons adversley affects both the
pre- and post- synaptic neurons.
![Page 5: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/5.jpg)
Ion dysregulation via stimulation of glutamate receptors
![Page 6: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/6.jpg)
“programed” cell death
![Page 7: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/7.jpg)
Role of Mitochondria in synaptic plasticity
![Page 8: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/8.jpg)
AD oxidative damage
![Page 9: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/9.jpg)
Obesity and cognitive cognition
![Page 10: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/10.jpg)
Physical exercise and SNRI synergistic effect
![Page 11: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/11.jpg)
Beneficial molecular changes due to hormesis
![Page 12: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/12.jpg)
Phytochemicals vs. refined sugars
![Page 13: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/13.jpg)
Factors mediating Neurodegenerative disease upon aging
![Page 14: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/14.jpg)
![Page 15: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/15.jpg)
Promoting adaptive mechanism against neurodegenerative disorders
![Page 16: Ageing Brain, environmental factors and metabolism](https://reader035.fdocuments.us/reader035/viewer/2022062316/568166ff550346895ddb65f9/html5/thumbnails/16.jpg)
Thanks for listening