Age related macular degeneration - a glimpse into the future by Jaheed Khan
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Transcript of Age related macular degeneration - a glimpse into the future by Jaheed Khan
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AMD – a glimpse into the futureJaheed Khan
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Symptoms of AMD
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Dry AMD
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Wet AMD
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Wet AMD scarring
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Dry AMD OCT
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OCT wet AMD
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Treatments for Dry AMD
No medical treatment for dry type
Magnifying vision and good illumination help
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IMT for end stage AMD
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Focal laser for wet AMD
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Photodynamic therapy
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RPE Cell Translocation
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VEGF
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Anti –VEGF Rx
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Anti-VEGF differences
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Radiotherapy Rx for wet AMD
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Future AMD Rx
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Future AMD Rx
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Future AMD Rx
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Future AMD Rx
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Future AMD Rx
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Future AMD Rx
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Future AMD RxDry AMD pipeline: most promising candidates
• Ciliary Neurotrophic Factor: Neuroprotective implant, phase II• Fenretinide: Decreases serum retinol, oral, phase II• OT-551: Anti-oxidant, anti inflammatory, topical, phase II• POT-4: Complement C3 inhibitor, phase II• Glatiramer Acetate: Immunomodulator, subcutaneous, phase II• Rheopheresis: Plasmapheresis, phase III
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Future AMD RxWet AMD pipeline: most promising candidates • adPEDF.11: Gene therapy, intravitreal injection, phase I• AGN211745: siRNA, intravitreal injection, phase II• Zybrestat: vascular disrupting agent, topical, animal studies• Sirolimus: Multi-mechanism, Subconjunctival or intravitreal injection or oral, phase II• ATG003: nAChR antagonist, topical , phase II• Vatalanib: Tyrosine kinase inhibitor, oral, phase II• Pazopanib: Tyrosine kinase inhibitor, , topical , phase II• TG101095 / TG100801: Tyrosine kinase inhibitor, topical, phase II• AL-39324: Tyrosine kinase inhibitor, intravitreal injection, animal studies• AG013958: Tyrosine kinase inhibitor, subtenon injection, animal studies• JSM6427: integrin antagonist, intravitreal injection, phase I• PF-04523655 (REDD14NP) Wet AMD; phase I (Quark/Pfizer)
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AMD – a glimpse into the future