African Black patients have slower recovery from IV anaesthesia
1
Inpharma 1317 - 8 Dec 2001 African Black patients have slower recovery from IV anaesthesia The recovery from IV general anaesthesia with propofol and remifentanil is slower in African Black patients than in Caucasian patients, reports a multinational group of researchers. They compared 45 Black patients from Senegal and 45 Caucasian patients from Italy undergoing lower abdominal surgery lasting 60–90 minutes who received general anaesthesia with IV remifentanil 15 µg/kg/hour, IV propofol 1.5 mg/kg bolus followed by 10 mg/kg/hour and vecuronium 0.05 mg/kg. No significant between-group differences in mean bispectral index values were found at baseline or intraoperatively. However, the mean bispectral index values were significantly higher 3 minutes after discontinuing propofol (prerecovery phase) and significantly lower 3 minutes later (recovery phase) in Black patients, compared with Caucasian patients (+26% and –14%, respectively). Importantly, Black patients, compared with Caucasian patients, took significantly longer after discontinuation of propofol to respond to loud verbal commands (14.8 vs 9.1 minutes) and to open their eyes (16.9 vs 10.6 minutes). The researchers comment that the different sensitivities to these drugs ‘may be caused both by genetic factors and by life habits (health, nutrition, enzymatic induction, physical exercise, etc.)’. They add that research into these differences ‘is of great importance in preparing and trimming models for automated infusion systems that have been established only for Caucasians’. Ortolani O, et al. The recovery of Senegalese African Blacks from intravenous anesthesia with propofol and remifentanil is slower than that of Caucasians. Anesthesia and Analgesia 93: 1222-1226, Nov 2001 800876835 1 Inpharma 8 Dec 2001 No. 1317 1173-8324/10/1317-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of African Black patients have slower recovery from IV anaesthesia
Inpharma 1317 - 8 Dec 2001
African Black patients have slowerrecovery from IV anaesthesia
The recovery from IV general anaesthesia withpropofol and remifentanil is slower in African Blackpatients than in Caucasian patients, reports amultinational group of researchers.
They compared 45 Black patients from Senegal and 45Caucasian patients from Italy undergoing lowerabdominal surgery lasting 60–90 minutes who receivedgeneral anaesthesia with IV remifentanil 15 µg/kg/hour,IV propofol 1.5 mg/kg bolus followed by 10 mg/kg/hourand vecuronium 0.05 mg/kg.
No significant between-group differences in meanbispectral index values were found at baseline orintraoperatively. However, the mean bispectral indexvalues were significantly higher 3 minutes afterdiscontinuing propofol (prerecovery phase) andsignificantly lower 3 minutes later (recovery phase) inBlack patients, compared with Caucasian patients(+26% and –14%, respectively).
Importantly, Black patients, compared with Caucasianpatients, took significantly longer after discontinuationof propofol to respond to loud verbal commands (14.8vs 9.1 minutes) and to open their eyes (16.9 vs 10.6minutes).
The researchers comment that the differentsensitivities to these drugs ‘may be caused both bygenetic factors and by life habits (health, nutrition,enzymatic induction, physical exercise, etc.)’. They addthat research into these differences ‘is of greatimportance in preparing and trimming models forautomated infusion systems that have been establishedonly for Caucasians’.Ortolani O, et al. The recovery of Senegalese African Blacks from intravenousanesthesia with propofol and remifentanil is slower than that of Caucasians.Anesthesia and Analgesia 93: 1222-1226, Nov 2001 800876835
1
Inpharma 8 Dec 2001 No. 13171173-8324/10/1317-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
