Affidavit of Bryan a. Krumm RN 8-16-00

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    It has been shown that

    different cannabinoids act synergistically to produce greater therapeutic effect

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    than single cannabinoid therapy. When the

    receptor agonist, palmitoylethanolamide,

    they produce an analgesic effect one hundred times greater than either

    substance when administered by itself (22).The reason for this synergistic effect is that the human body contains different

    types of cannabinoid receptors, which react differently to different cannabinoids,

    and are involved in different aspects of the disease process. For instance, THC

    It has also been shown that

    the use of cannabinoids, such as those found in marijuana, may be effective in

    treating many of those diseases

    Rd, Edgewood, NM 87015,(505) 286-1325.

    am working with New Mexicans for

    Compassionate Use to end the damage caused to our society by the war on

    drugs. I am recognized by the New Mexico court system as an expert on the

    medical uses of marijuana and the history of medical marijuana. I have been

    studying the history, effects, and uses of marijuana for over 15 years. I am the

    chief researcher for the Cannabis Research Library, the largest online collection

    of cannabis research in the world

    I use marijuana for the treatment of depression and knee pain, and my

    primary care physician has referred me to the Lynn Pierson Therapeutic

    Research Program. This program was established under the Controlled

    Substances Therapeutic Research Act in 1978, and allows the medical use of

    marijuana in New Mexico. Under this program, research was conducted which

    proved the safety and efficacy of smoked marijuana for the treatment of multiple

    sclerosis and for treating the nausea and vomiting associated with cancer

    chemotherapy. Unfortunately, the unreasonable, arbitrary and capricious actions

    of the US government led to closure of the program when they refused toapprove further research protocols and then cut off our supply of marijuana

    entirely. Therefore, I have three choices. I can turn to an unreliable and

    dangerous black market. I can risk losing everything I have by cultivating my

    own medicine_ Or, I can go without a needed medication that has unique

    pharmacological properties, which can not be mimicked by any other known

    class of drug.

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    The human body contains a complex system of cannabinoid receptors and

    produces its own cannabinoids

    forming an endogenous cannabinoid

    system that is involved in normal homeostasis of the immune system

    transmission of pain responses

    am 37 years old. I am a registered nurse at the University of

    New Mexico Mental Health Center and

    It

    has been shown that dysfunction of the endogenous cannabinoid system is

    involved in certain disease states

    receptor agonist, anandamide,

    is given at the same time as the

    Affidavit of Bryan A. Krumm RN

    My name is Bryan Alan Krurnm.

    live at 17

    perception, and mood

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    is available legally in the United States as a Schedule III drug. THC is a strong

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    receptor agonist but has minimal activity at the CB2 receptor and may

    actually act as an antagonist at the CB2 receptor (14). CB2 receptor agonists

    may prove to be an important class of medications for the treatment of

    autoimmune diseases (7, 24) and are found in whole marijuana but not in THCcapsules.

    Cannabinoids have been shown to protect the brain against damage from

    stroke and trauma

    and may protect against neurodegenerative

    disorders such as alzheimers and multiple sclerosis (26, 27, 28). Cannabinoids

    may also protect against certain types of cancer (29) and have been shown to

    inhibit proliferation of certain types of tumor cells

    31, 32) and reduce tumor

    size. (31) They are effective in treating various movement disorders (33, 34, 35,

    36) and hold potential for treatment of various psychiatric disorders (37, 38, 39,40).

    Marijuana is far safer than most medications available to us. Inquiries into

    the health effects of cannabis has found it to be an incredibly safe drug (41). In

    over 5,000 years of use, there has never been a recorded fatal overdose. An

    individual would have to smoke over a thousand high potency cannabis

    cigarettes in order to have a toxic reaction, making it impossible to have a fatal

    overdose (42). The low density of receptors in

    nuclei is consistent with

    the lack of lethal effects in humans (43). The studies on chronic marijuana use

    that have been conducted suggest that tolerance rapidly develops to many of the

    effects of cannabis use and field studies have failed to find any major

    consequences from chronic heavy use of cannabis (44). No clinical evidence

    has been discovered suggesting increased prevalence of opportunistic infection

    or malignancy among cannabis users (45). A study of 65,171 individuals found

    that marijuana use has little effect in non-AIDS mortality in men and total

    mortality in women. The effect on AIDS related mortality in men was probably

    not causal but rather represented an uncontrolled confounding factor associated

    with male homosexual behavior (46).

    Although the federal government is aware of the therapeutic potential ofmarijuana, they have routinely suppressed scientific findings. For example, a

    two-year study of THC was conducted on rats and mice that found THC treated

    animals had significantly lower rates of many types of cancer. This report was

    shelved for over two years until a copy was leaked to AIDS Treatment News,

    stamped on every page NOT FOR DISTRIBUTION OR ATTRIBUTION (47).

    Health and Human Services quickly made a version available to the public after

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    being confronted with the leaked copy (29).

    Another example is the 1997 NIH Workshop on the Medical Utility of

    Marijuana. The transcripts from the workshop show that the panel of experts

    agreed marijuana has medical value (48). It was even found that the evidence

    is perfectly clear that smoking is an outstanding route of administration...& a

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    very safe drug and therefore it would be perfectly safe medically to let the patient

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    determine their own dose through the smoking route (ibid

    The

    Executive Summary that was issued to the public by NIH was far less

    enthusiastic than the group of experts. It recommended further research and no

    smoking (49).

    This comes as little surprise. For over a century, every serious scientific

    inquiry into the effects of marijuana have found it to be an incredibly safe drug

    that causes little harm to society. It has routinely been found that marijuana

    prohibition, causes more harm to society than marijuana use (41). The US

    Government has routinely ignored science, as well as the will of The People,

    who have passed medical marijuana measures. They continue to persecute all

    marijuana users, including those who need its important healing properties. After

    all, marijuana prohibition is founded in racism and intolerance, not science. At a

    luncheon, October

    Director of the Office of National Drug Control Policy, why he

    still supports persecuting medical marijuana users such as myself. I pointed out

    that the report he commissioned from the Institute of Medicine recommended

    allowing smoked marijuana for medical use under certain circumstances (50).

    He responded to a room full of people that the report was available on his web

    site and that it did not recommend smoked marijuana under any circumstances.

    Then he called medical marijuana a crock.

    When the Mexican American War was ended by the Treaty of Guadalupe

    Hidalgo, it did not end the hostile feelings many Americans harbored towards

    Mexicans. As Mexicans immigrated to the western states and took scarce jobs,

    it created more tension. These immigrants also brought their cultural and

    religious traditions, one of which was the use of marijuana for medical,

    religious, and recreational purposes.

    Within the traditions of Curanderismo, marijuana is called La Santa Rosa, or

    the sacred rose. It is used as part of a religious healing ceremony and is

    considered to be a piece of the heart of God

    marijuana laws in 1929, the Montana Legislature, described such a ceremony as

    an imaginary bullfight for the favor of Spanish Rose and went on to say itdeplores these international complications (53).

    When passing early marijuana laws, numerous state legislatures described

    marijuana as a drug that causes Mexicans to go insane

    City Editor of The Alamosa Daily Courier of Alamosa, Colorado, which was read

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    into the record of the hearings on the 1937 Marihuana Tax Act (the first federal

    law regulating marijuana) by Harry J. Anslinger, Commissioner of the Federal

    Bureau of Narcotics. This letter stated in part:

    I wish I could show you what a small marihuana cigarette can do to

    The attitudes and

    intent of the people of Colorado are illustrated in a letter from Floyd K.

    in Albuquerque, I had the opportunity to ask General

    Barry

    When passing its first

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    abiding citizens.

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    Prohibition serves to protect the financial interests of industries that would

    have to compete with marijuana in a free market. It assures the financial

    success of those responsible for waging this war on the American People. It

    strips us of our inalienable rights to life, liberty, and the pursuit of happiness. I

    live in fear that a small army of masked gunmen may come bursting through my

    door at 3 am and shoot me in the back while Im lying in bed, simply for being a

    medical marijuana user. In view of the number of deaths by drug warrior our

    society has suffered, its a very real fear for medical marijuana patients living in

    the United States.

    REFERENCES

    1. Howlett AC. Pharmacology of cannabinoid receptors. Annu Rev Pharmacol

    Toxicol.

    came to testify for the AMA testifying that, The American Medical Association

    knows of no evidence that marihuana is a dangerous drug. One of theCongressmen said in response, Doctor, if you cant say something good about

    what we are trying to do, why dont you go home? The next Congressman said,

    Doctor, if you havent got something better to say than that, we are sick of

    hearing you. (55)

    Early marijuana laws were intended not only to oppress Mexican immigrants,

    but to prevent them from the free practice of religion. Today these laws not only

    prevent millions of Americans from freely practicing religion but millions more

    suffer from lack of needed medication under these oppressive policies. Millions

    of others have suffered the severe legal and social consequences associated

    with being arrested for marijuana use. There is no scientific rationale to justify

    the

    2. Abood ME and Martin BR. Molecular neurobiology of the cannabinoid

    receptor.

    was Chief Counsel to the American Medical Association. The AMA

    was aware of the therapeutic potential of marijuana (or as they knew it,

    cannabis) and did not want it to be removed from medical use. Dr.

    one of our degenerate Spanish-speaking residents. Thats

    why our problem is so great; the greatest percentage of our

    population is composed of Spanish-speaking persons, most of

    who are low mentally, because of social and racial conditions (54).

    While this was considered in passing federal anti-marijuana legislation, the

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    opinion of the American Medical Association was ignored. Dr. William

    Rev Neurobiol.

    criminalization and persecution of millions of otherwise

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    3. Devane WA,

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  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

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    chromatography

    11. Meng ID, Manning BH, Martin WJ and Fields HL. An analgesia circuit

    activated by cannabinoids. Nature.

    MC; Pain modulation by release of the endogenous cannabinoid

    anandamide (analgesia

    mesylate, a high affinity cannabinoid agonist, in a rat model of

    neuropathic pain. Neurosci Let.

    -l 949.

    14. Felder, CC

    12. Walker, MJ; Huang, SM, Strangman, NM; Tsou, K; and

    Herzberg U, Eliav E, Bennett GJ and Kopin IJ. The analgesic effects of

    Martin WJ, Hohmann AG and Walker JM. Suppression of noxious

    J, Fride E,

    mass spectrometry) PNAS; 1999; 96: 12198-I 2203,

    periaqueductal gray

    1998;

    microdialysis

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    17/29

    15. Molina-Holgado, F; Molina-Holgado, E; Guaza, C; The endogenous

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    18/29

    cannabinoid anandamide potentiates interleukin-6 production by astrocytes

    infected with Theilers murine encephalomyelitis virus by a receptor-mediated

    pathway. Feb Lett; 1998; 433: 139-142.

    16.

    17. Richardson JD; Aanonsen L; Hargreaves KM; Hypoactivity of the spinal

    cannabinoid system results in NMDA-dependent hyperalgesia. J Neurosci 1998,

    tetrahydrocannabinol are neuroprotective antioxidants. PNAS 1998; 95: 8268-

    8273.

    HM; Leweke, FM; Schneider, U; Towards a cannabinoid hypothesis

    of schizophrenia: cognitive impairments due to dysregulation of the endogenous

    cannabinoid system. Pharmacology, Biochemistry

    MC; Walker JM; Role of the subthalamic nucleus in

    cannabinoid actions in the substantia nigra of the rat. J Neurophysiol, 1997,

    77:

    19. Smith PB, Compton DR, Welch SP, et al. The pharmacological activity of

    anandamide, a putative endogenous cannabinoid in mice. J Pharmacol Exp

    Ther.

    A; Waksmann, Y; Ovadia, H; Weidenfeld, J; Bar-Joseph,

    A; Biegon, A.; Mechoulam, R; and Shohami, E; Protection Against Septic Shock

    and Suppression of Tumor Necrosis Factor and Nitric Oxide Production by

    Dexanabinol (HU-21 I), a Nonpsychotropic Cannabinoid. J Pharm Exp Ther,

    1997; 283: 918-924, 1997.

    21. Lyman WD, Sonett JR, Brosnan CF, et al.

    a novel

    treatment for experimental autoimmune encephalomyelitis. J Neuroimmunol.

    22. Calignano A, La

    20.

    Giuffrida A and Piomelli D. Control of pain initiation

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    19/29

    by endogenous cannabinoids. Nature.

    23. Hampson, A; Grimaldi, M; Axelrod, J; and Wink, K; Cannabidiol and

    Jbilo. Stimulation of peripheral cannabinoid receptor CB2 inducesMCP-1 and IL-8 gene expression in human promyelocytic cell line HL60. FEBS

    Letters Volume 448, Issue 2-3,

    pp. 273-277

    25. Nagayama, T;

    Jin, K; and

    Greenberg, DA; Cannabinoids and Neuroprotection in Global and Focal Cerebral

    lschemia and in

    R;

    Cultures. J Neurosci; 1999,

    AD; Simon, RP; Chen, J;

    Behavior; 1997;

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    20/29

    26. Shen M; Thayer SA; Cannabinoid receptor agonists protect cultured rat

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    21/29

    hippocampal neurons from excitotoxicity. Mol Pharmacol, 1998;

    28. Yaakov Waksman, John M. Olson, Steven J. Carlisle and Guy A. Cabral

    The Central Cannabinoid Receptor

    Trans-Delta(S)-Tetrahydrocannabinol (CAS No.

    Mice (Gavage Studies); NTP TR 446, NIH Publication No. 94-3362, of

    the U.S. Department of Health and Human Services, Nov.1996

    30. De Petrocellis L;

    31. Munson AE, Harris LS, Friedman MA, Dewey WL, Carchman RA,

    Antineoplastic activity of cannabinoids. J

    Tetrahydrocannabinol induces apoptosis in

    R. The perceived effects of

    smoked cannabis on patients with multiple sclerosis. European Neurology.

    27. Francisco Molina-Holgado, Eduardo Molina-Holgado, Carmen Guaza. The

    endogenous cannabinoid anandamide potentiates interleukin-6 production by

    astrocytes infected with

    Mediates Inhibition of Nitric Oxide

    Production by Rat Microglial Cellsl. JPET, Vol. 288, Issue 3, 1357-l 366, March

    1999

    29. NTP Technical Report on the Toxicology and Carcinogenesis Studies of

    glioma cells. Feb Lett, 1998;

    436: 6-10.

    33. B.-Y. Zeng, B. Dass, A. Owen, S. Rose, C. Cannizzaro, B.C. Tel and

    treatment increases striatal

    cannabinoid

    rats. Neuroscience Letters, Volume 276, Issue 2, December 1999, Pages 71-74

    34. Self DW. Anandamide: a candidate neurotransmitter heads for the big

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    22/29

    leagues. Comment on: Nat Neurosci 1999

    1999 Apr.

    35.

    MC. Walker JM. Role of the subthalamic nucleus incannabinoid actions in the substantia

    nigra of the rat. Journal of Neurophysiology.

    1997 Mar.

    36.

    mediated pathway. Febs Letters Vol. 433 (1-2) pp. 139-I 42,

    Bifulco M; Di

    Marzo V; The endogenous cannabinoid anandamide inhibits human breastcancer cell proliferation.

    Nature

    Neuroscience.

    1997.

    P. Musty R. Rein J. Tiller-y W.

    receptor

    D; Palmisano A; Bisogno T; Laezza

    I;

    Chronic

    murine encephalomyelitis virus by a

    expression in

    Sci, 1998;

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    23/29

    C;

    Cancer Inst, 1975;

    P;

    in

    M; Delta

    Rats and

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    24/29

    37. Navarro M. Hernandez E. Munoz RM. del

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    25/29

    1972

    Jul.

    41. Zimmer L and Morgan JP. Marijuana Myths Marijuana Facts: A Review of the

    Scientific Evidence, (1997) pages 6-l 5 (The Lindesmith Center, New York).42. Petro

    L, Martin BR. Search for endogenous ligands of

    the cannabinoid receptor.

    118.

    46. Sidney S, Beck JE, Tekawa IS, et al. Marijuana use and mortality. Am

    Treated Rats Lived Longer, Had Less Cancer, AIDS Treatment News 1997; 26348. National Institutes of Health. Transcript of the NIH Workshop on the Medical

    Utility of Marijuana. Tab B, Deliberations of the Ad Hoc Group of Experts;

    February

    Ref Type:

    Transcript,

    cannabinoid receptor

    antagonist SR

    1997 Jan 20.

    38. Zuardi AW. Morais SL. Guimaraes FS. Mechoulam R. Antipsychotic effect

    of cannabidiol [letter]. Journal of Clinical Psychiatry.

    1995 Oct.

    39.

    J.

    Souilhac

    Blockade of cannabinoid receptors by

    SRI 41716 selectively increases Fos expression in rat mesocorticolimbic areas

    via reduced dopamine D2 function. Neuroscience, Volume 91, Issue 2

    Pharmacology and toxicity of cannabis, In: Mathre ML, ed.,

    Cannabis in Medical Practice, A Legal, Historical and Pharmacological Overview

    of the Use of Marijuana, (1997) pages 56-66 (McFarland & Company, Inc.,

    Publishers, Jefferson, North Carolina).

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    26/29

    43. Mechoulam R and

    1537-l 544.

    44. Hollister LE. Health aspects of cannabis.

    45. Hollister LE. Cannabis-l 988.

    49. Executive Summary of the Workshop on the Medical Utility of Marijuana;

    National Institutes of Health; February

    I. Villanua MA. Carrera MR.

    Rodriguez de Fonseca F. Acute administration of the

    Alonso *A, B. Voutsinos

    J.S.; Medical Marijuana: Unpublished Federal Study Found

    Le Fur * and P. Soubrie

    1997. (Ace-Federal Reporters, Inc.,

    in melancholia. 1874. Medical Times.

    induces anxiety-like responses in the rat. Neuroreport.

    M. Fournier

    1997.

    C. Labie

    Rev.

    R. Steinberg

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    27/29

    Pub

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    28/29

    V, ed., Cannabis and Culture, (1973) pages 147-172 (Mouton Publishers,

  • 8/8/2019 Affidavit of Bryan a. Krumm RN 8-16-00

    29/29

    Paris).

    52. Furst, PT; Flesh of the Gods, the Ritual Use of Hallucinogens (1972)

    (Waveland Press Inc, Prospect Heights)

    53. Richard J. Bonnie and Charles H. Whitebread, II; The Forbidden Fruit and

    the Tree of Knowledge: An Inquiry into the Legal History of American Marijuana

    Prohibition. Virginia Law Review 971-I 203 (1970).

    54. The Marihuana Tax Act of 1937, Transcripts of Congressional Hearings,

    Additional Statement of H. J. Anslinger, Commissioner of Narcotics

    55. Charles H. Whitebread, II, The History of the Non-Medical Use of

    Drugs in the United States (last modified April 6, 1997)

    Affidavit of Bryan Alan Krumm

    50. Marijuana and Medicine: Assessing the Science Base; Executive Summary;

    recommendation 5. National Academy of Sciences, Institute of Medicine;

    Academy Press 1999.

    51. Partridge WL. Cannabis and cultural groups in a Colombian municipo, In:

    Signed this

    2000

    Subscribed and sworn to before me this 16th day of August, 2000 by Bryan

    Alan Krumm.

    day of