Affect of DNA-PK on Foci Persistence
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Affect of DNA-PK on Foci Persistence J. Dickey
description
Affect of DNA-PK on Foci Persistence. J. Dickey. J Cell Controls (0 Gy). 0 hr. 48 hr. 24 hr. 72 hr. K Cell Controls (0 Gy). 0 hr. 48 hr. 24 hr. 72 hr. J Cells 3 Gy. 0.5 hr. 1 hr. 3 hr. 6 hr. 10 hr. 24 hr. 48 hr. 72 hr. K Cells 3 Gy. 0.5 hr. 1 hr. 3 hr. 6 hr. 10 hr. 24 hr. - PowerPoint PPT Presentation
Transcript of Affect of DNA-PK on Foci Persistence
![Page 1: Affect of DNA-PK on Foci Persistence](https://reader035.fdocuments.us/reader035/viewer/2022062304/5681462a550346895db3373b/html5/thumbnails/1.jpg)
Affect of DNA-PK on Foci Persistence
J. Dickey
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J Cell Controls (0 Gy)0 hr
24 hr
48 hr
72 hr
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K Cell Controls (0 Gy)0 hr
24 hr
48 hr
72 hr
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J Cells 3 Gy
1 hr 3 hr 6 hr
10 hr 24 hr
0.5 hr
48 hr 72 hr
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K Cells 3 Gy1 hr 3 hr 6 hr
10 hr 24 hr
0.5 hr
48 hr 72 hr
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J Cells 5 Gy
1 hr 3 hr 6 hr
10 hr 24 hr
0.5 hr
48 hr 72 hr
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K Cells 5 Gy1 hr 3 hr 6 hr
10 hr 24 hr
0.5 hr
48 hr 72 hr
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J vs. K cells 10 hr post 3 Gy IR
J Cells K Cells
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J vs. K cells 10 hr post 5 Gy IR
J Cells K Cells
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Conclusions
• J cells (deficient in DNA-PK expression) have greater foci persistence over time after IR.
• Overall numbers of foci between J cells and K cells at 30 min post-IR seem similar.
• DNA-PK seems to play a role in foci removal.