AF Ablation: How has the Technique and Technology developed ?
-
Upload
bianca-mullins -
Category
Documents
-
view
42 -
download
3
description
Transcript of AF Ablation: How has the Technique and Technology developed ?
![Page 1: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/1.jpg)
AF Ablation: How has the Technique and Technology
developed?Professeur Dipen ShahResponsable de l’Unité d’électrophysiologie,
Hopital Cantonal de Geneve,Geneve7th International Congress of Egyptian Cardiac Rhythm Association
15th-17th December 2010, Cairo
![Page 2: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/2.jpg)
Architecture of the junction between pulmonary veins and the left atrium: lessons for radiofrequency ablation
25 year Male
Right Left
60y Male 60y Male 80y Female
Left upper
Ho SY et al, Heart 2001
Isthmus between veins at veno-atrial junction
Left upper
Left upper
Left lower
Left lower
Left lower
Common vein
![Page 3: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/3.jpg)
PV Ablation Options
• Sequential point by point ablation
• Simple• Individual optimisation of
lesion delivery possible• Obligatorily time consuming• Finite irreducible rate of gap
occurrence• Circular lesion making
devices• Unfamiliar, more complex
design• Difficult to optimise contact/to
generate consistent lesions• Still do not achieve rapid,
one-shot isolation
![Page 4: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/4.jpg)
Zheng et al, Journal of Interventional Cardiac Electrophysiology 5, 401–410, 2001
![Page 5: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/5.jpg)
Linear Ablation Technologies
PV ablation times: segmental PVI: 35+15 min Hocini et al. and CPVA:37+11 min Oral et al. PVAC: Boersma et al. 27+7 min, & Scharf et al. 32+12 min
![Page 6: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/6.jpg)
Multi-electrode PVAC • Incomplete circular form resulting in
suboptimal circular mapping• Combination of bipolar and unipolar RF difficult
to titrate• Noise does not allow electrogram monitoring
during RF• Uniform contact essential for bipolar RF
efficacy but unknown• No irrigation: uncertain protection from
char/coagulum• Ablation times similar to segmental PVI: no
single shot ablation
![Page 7: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/7.jpg)
Cryoballoon AblationPre-Cryo Post-Cryo
LSPV Location of conduction recovery at redoImage courtesy V. Reddy
![Page 8: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/8.jpg)
Cryo-Balloon
• Cryo-ablation in circulating blood: time consuming and probably smaller lesions
• PV anatomy oval not circular: single-shot ablation not frequent
• Inferior PVs difficult to isolate
• Significant risk of phrenic palsy
• No immunity from esophageal damage
Pacing Catheter in SVC
Cryoballoon Catheter at
RSPV ostium
Image courtesy V. Reddy
![Page 9: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/9.jpg)
Visually-Guided Ablation
Aiming Beam
“Static” Blood in LSPV
LIPVLAA
![Page 10: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/10.jpg)
In Vivo Visually-Guided A.Flutter Ablation
V.Reddy / P.Neuzil (manuscript in preparation)
![Page 11: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/11.jpg)
Contact Sensing
0
500
1000
1500
2000
Contact Force (g)
2 10 20 30 40 2 10 20 30 40
500
1000
1500
2000
445
683
906
1186
1542
271
431
632773
1052
p <0.01 p <0.01
30W 50W
(mm3)
Lesion Volume vs. Contact Force
Contact Force (g)
Incidence of Steam Pop
(%)
20
40
60
80
100
2 10 20 30 40
0/10
5/10
6/10
7/10
8/10
50W p =0.0026
0
20
40
60
80
100
2 10 20 30 40
0/10 0/10 0/10 0/10
3/10
30W p =0.031
(%)
Yokoyama K, Nakagawa H, Shah D et alCirc Arrhythmia EP 2008
![Page 12: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/12.jpg)
12%
Source: K-H Kuck, presentation Boston AF 2010
12 % of ablations done with low contact forces (< 5 g)
0%
5%
10%
15%
20%
25%
30%
35%
%ag
e o
f ab
lati
on
s d
on
e w
ith
co
nta
ct f
orc
e <
5g
12%
RIGHT PVs
Septal Sup.
Septal Inf. Roof Middle Inferior Post.
Sup. Post. Inf.
Low forces 15% 12% 3% 13% 23% 12% 11%
LEFT PVs
Post. Sup. Post. Inf. Roof Middle Inferior Ant. Sup. Ant. Inf.
8% 4% 7% 23% 7% 21% 32%
RPV
Post
LPV
An
terS
ep
tal
Roof
Inf
32%
![Page 13: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/13.jpg)
Sheath assisted Perforation
0
50
100
150
200
250
300
1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41
RV without sheath RV with sheath
RV **
0
100
200
300
400
500
600
1 6 11 16 21 26 31 36 41 46 51 56 61 66 71 76 81 86 91 96 101
LV without sheath LV with sheath
LVw/o sheath
with sheath
w/o sheath
with sheath
Peak Df/dt: LV perforation
LV perforation time:
0.8±0.5s with sheath vs 3.2±3 s w/o, p<0.0001
gra
ms
time time
736 ± 368 g/sec
239±178 g/sec
p = 0.0013
Shah D et al, Europace 2010
![Page 14: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/14.jpg)
Perforating Force thru’ RF lesions
172±79g
300±116g
p<0.002
n= 23 n= 21
Shah D et al, Europace 2010
![Page 15: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/15.jpg)
Remote Navigation Systems
• Magnetic Navigation: Fixed Magnets (Stereotaxis)• Magnetic Navigation: Electro-Magnets (Magnetecs)• Robotic Navigation (Hansen Medical)
Fixed Magnetic Nav Robotic Nav
Electro-Magnetic Nav
![Page 16: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/16.jpg)
Arya et al, Europace 2010 e-pub
![Page 17: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/17.jpg)
robotic arm
Sensei™ Robotic Catheter System
3D mouse
![Page 18: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/18.jpg)
Electromechanic Navigation
• 34 of 40 pts off anti-arrhythmic drugs and „free from atrial arrhythmia“ 85%
• 5 pts still on anti-arrhythmic medication
• 2 pts with perforations/tamponade
Atrial fibrillation ablation
Saliba et al. JACC Vol. 51, No. 25, 2008:2407–11
Wazni et al, JCE 2009• 71 patients undergoing PV antral
isolation• 5 vascular complications• 3 tamponade• 5 severe PV stenosis• 1 gastroparesis
• 4/4 pts with esophageal ulceration at endoscopy on the post-ablation day
• 1/4 pts developed esophageal fistula formation necessitating stenting
Kuck KH, EHRA-Webinar AF ablation, March 2009
![Page 19: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/19.jpg)
Electro-mechanical Navigation
• Point by point mapping and ablation: no reduction in procedure time
• Extra –stiff sheath and poor contact force monitoring: higher risk of traumatic perforation and other complications
• Single catheter control only• AF ablation poorly suited to automated,
fully robotic procedure
![Page 20: AF Ablation: How has the Technique and Technology developed ?](https://reader036.fdocuments.us/reader036/viewer/2022062309/56813854550346895d9ffe83/html5/thumbnails/20.jpg)
Technology for AF Ablation
• New technology should simplify ablation
• Shorten the procedure by reducing ablation times
• Provide rapid and reliable endpoint verification
• Result in durable, non-proarrhythmic lines of isolation
• Should not increase complication risks
Current standard of reference…