ADVANCED IOL POWER CALCULATIONS Jack T. …. ADVANCED-IOL-CALCS-w-Outline...ADVANCED IOL...

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Jack T. Holladay, M.D., M.S.E.E., F.A.C.S. Page 1 of 2 ADVANCED IOL POWER CALCULATIONS Jack T. Holladay, MD, MSEE, FACS I. Formulas and Measurements A. Variables Used to Predict ACD 1. Binkhorst 2 - 1981 - AL 2. Holladay 1 - 1988 - AL, K 3. SRK/T - 1990 - AL, K 4. Hoffer Q - 1993 - AL, K 5. Olsen - 1995 - AL, K, ACD 6. Clarke- 1996 - AL, K1, K2 ACD, LT 7. Holladay 2 - 1996 - AL, K, HWTW, REF, ACD, LT, AGE B. Normal Values for required Measurements 1. Axial Length: mean = 23.5 mm, SD = 1.25 mm 2. Keratometry: mean = 43.81 D, SD = 1.6 D 3. Horizontal White-to-White (Corneal diameter): mean = 11.7 mm, SD = 0.46 mm 4. Preoperative Refraction: mean = plano 5. Anterior Chamber Depth (ultrasonic): mean = 3.1 mm, SD = 0.30 mm 6. Crystalline Lens Thickness (ultrasonic): mean = 4.7 mm, SD = 0.41 mm 7. Age: mean = 72, SD = 12 years II. Axial length Measurements in Aphakic and Pseudophakic eyes A. Aphakia - 1532 M/sec B. Pseudophakia 1. PMMA - 2718 M/sec 2. Silicone - 980 M/sec 3. Acrylic- 2120 M/sec III. Determination of corneal power following Keratorefrative Sx (PRK, LASIK, RK) A. Manual Keratometry B. Automated Keratometry C. Corneal Topography D. Calculation from pre- keratorefractive surgery K’s E. Determination from hard contact lens trial IV. Data Screening Techniques on Preoperative Measurements A. Probability of unusual measurements (one eye only) B. Probability of asymmetrical measurements (both eyes) V. IOL Calculations requiring Axial Length Measurements A. Standard Cataract Removal with IOL 1. Piggy-Back IOL’s: Use 34 D IOL posterior in bag 2. Multifocal IOL’s: Target distance plano, near for -3.00 D. 3. Toric IOL’s: IOL Cylinder to Corneal Cylinder ~ 1.46, but not exact for low (1.75) and high (1.20) power IOLs a. Optimization of Cataract Incision Location: Normal 4 locations for zero residual astigmatism b. Back calculation for surprise: 1) P.O. Refraction &, 2) P.O. Ks OR Current IOL axis B. Cataract Removal with IOL and Silicone in Vitreous: use convexplano ~ 3 D more, for biconvex ~ from 5 - 6 D more in IOL.

Transcript of ADVANCED IOL POWER CALCULATIONS Jack T. …. ADVANCED-IOL-CALCS-w-Outline...ADVANCED IOL...

Jack T. Holladay, M.D., M.S.E.E., F.A.C.S.

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ADVANCED IOL POWER CALCULATIONS

Jack T. Holladay, MD, MSEE, FACS I. Formulas and Measurements

A. Variables Used to Predict ACD 1. Binkhorst 2 - 1981 - AL 2. Holladay 1 - 1988 - AL, K 3. SRK/T - 1990 - AL, K 4. Hoffer Q - 1993 - AL, K 5. Olsen - 1995 - AL, K, ACD 6. Clarke- 1996 - AL, K1, K2 ACD, LT 7. Holladay 2 - 1996 - AL, K, HWTW, REF, ACD, LT, AGE

B. Normal Values for required Measurements 1. Axial Length: mean = 23.5 mm, SD = 1.25 mm 2. Keratometry: mean = 43.81 D, SD = 1.6 D 3. Horizontal White-to-White (Corneal diameter): mean = 11.7 mm, SD = 0.46 mm 4. Preoperative Refraction: mean = plano 5. Anterior Chamber Depth (ultrasonic): mean = 3.1 mm, SD = 0.30 mm 6. Crystalline Lens Thickness (ultrasonic): mean = 4.7 mm, SD = 0.41 mm 7. Age: mean = 72, SD = 12 years

II. Axial length Measurements in Aphakic and Pseudophakic eyes A. Aphakia - 1532 M/sec B. Pseudophakia

1. PMMA - 2718 M/sec 2. Silicone - 980 M/sec 3. Acrylic- 2120 M/sec

III. Determination of corneal power following Keratorefrative Sx (PRK, LASIK, RK) A. Manual Keratometry B. Automated Keratometry C. Corneal Topography D. Calculation from pre- keratorefractive surgery K’s E. Determination from hard contact lens trial IV. Data Screening Techniques on Preoperative Measurements A. Probability of unusual measurements (one eye only) B. Probability of asymmetrical measurements (both eyes) V. IOL Calculations requiring Axial Length Measurements A. Standard Cataract Removal with IOL

1. Piggy-Back IOL’s: Use 34 D IOL posterior in bag 2. Multifocal IOL’s: Target distance plano, near for -3.00 D. 3. Toric IOL’s: IOL Cylinder to Corneal Cylinder ~ 1.46, but not exact for low (1.75) and high (1.20) power IOLs a. Optimization of Cataract Incision Location: Normal 4 locations for zero residual astigmatism b. Back calculation for surprise: 1) P.O. Refraction &, 2) P.O. Ks OR Current IOL axis

B. Cataract Removal with IOL and Silicone in Vitreous: use convexplano ~ 3 D more, for biconvex ~ from 5 - 6 D more in IOL.

Jack T. Holladay, M.D., M.S.E.E., F.A.C.S.

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VI. IOL Calculations not requiring Axial Length A. Secondary Implant for Aphakia: in sulcus or anterior chamber angle B. AC IOL in phakic patient: High myopia ( - IOL) & High hyperopia ( + IOL)

C. Secondary Piggy-Back IOL for high hyperopia (or myopia within 1 year) VII. Pediatric IOL calculations

A. Ideal Postoperative Target Refraction: plano to -1.00 D. B. Expected Myopic Shift with age: 4 D from age 2 to age 21.

VIII. Minimizing Prediction Error A. Personalizing Formula Constants (A-const, ACD or Surgeon Factor) B. Prediction Error vs. IOL Power C. Creating personalized constants for subgroups

1. Axial Length (< 22 mm or > 26 mm) 2. Keratometry (< 40 D or > 48 D) 3. Preoperative Refraction (< -4 D or > +4 D)

IX. Calculating SIRC (Surgically induced refractive change) A. From pre and post operative keratometry B. From pre and post operative refraction

X. Outcomes Analysis A. Prediction Error Analysis: Mean absolute prediction error should be < 0.50 D. B. Formula Comparisons: more predictors, better results in unusual eyes C. SIRC Results: Astigmatic Analysis D. Visual Acuity Results

1. Best corrected 2. Uncorrected

XI. Back-calculations A. For determining source of error with refractive surprise B. Comparison of back-calculated lens constant and actual lens constant

ADVANCED IOL CALCULATIONS 2016

JACK T. HOLLADAY, MD, MSEE, FACS Page 1 of 27

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AdvancedIOL Power Calculations

Jack T. Holladay, MD, MSEE, FACSClinical Professor of Ophthalmology

Baylor College of MedicineHouston, Texas, USA WWW.AAO.ORG

0

AMERICAN ACADEMY OF OPHTHALMOLOGY

Financial Disclosure I have the following financial interests or relationships to disclose:

Abbott Medical Optics: C; 

AcuFocus, Inc.: C,O; 

Alcon Laboratories, Inc.: C; 

ArcScan: C,O; 

Carl Zeiss Inc: C; 

Elenza: C,O; 

Oculus, Inc.: C; 

Visiometrics: C,O; 

Wavetec: C

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www.docholladay.com

Handouts

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Jack T. Holladay, MD, MSEE, FACS

Clinical Professor of Ophthalmology

Baylor College of Medicine

Houston, Texas

www.docholladay.com

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Vergence Formula

Theoretical Formula has not changed in 173 years

Physiologic Assumptions may be slightly different Retinal thickness

Corneal Index of Refraction8/26/2016 JTH 7

Vergence Formula

IOLAL ELP

DPostRxV

K

ELP

1336 13361336

10001000

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E L PEffective Lens Position

Distance from corneal vertex to principal plane of thin IOL (no thickness)

Same as ACD, but avoids confusion with anatomy

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Prediction of E L P

<1980 Constant (0) 4.5

1981 Binkhorst 2 (1) AL

1988 Holladay 1 (2) AL, K

1995 Olsen (4) AL, K, ACD, LT

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Prediction of E L P

1996 Holladay 2 (7) AL, K,

ACD, LT, HWTW, REF, AGE

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Investigation International Study - 1993 34 investigators (15 U.S.)

Additional measurements are

taken 35 eyes < 21 mm

35 eyes > 26 mm

35 eyes = normal8/26/2016 JTH 15

Measurements taken forPredictors of ELP

Axial Length Average K Horizontal WTW ACD LT Pre-opRefraction Age

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HWTW Gauge

Horizontal Corneal Diameter

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IOL MASTER 500 – ZEISSVersion 7.70

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LENSTAR – HAAG-STREIT

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0

200

400

600

800

1000

Anterior Segment Size

# o

f C

ase

s

Small Normal Large

Normal Eyes

2%

96%

2%

N = 824

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0

20

40

60

80

Anterior Segment Size

# of

Cas

es

Small Normal Large

Short Eyes ( < 21 mm)

20%

80%

0%

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0

20

40

60

80

Anterior Segment Size

# of

Cas

es

Small Normal Large

Long Eyes ( > 27 mm)

0%

90%

10%

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Normal Physiologic Values

Al: 23.5 mm + 1.25 mm

K: 43.81 D + 1.6 D

Hwtw: 11.7 mm + 0.46 mm

Ref: -0.60 D + 2.00 D

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Normal Physiologic Values

ACD: 3.1 mm + 0.30 mm

LT: 4.7 mm + 0.41 mm

Age: 72 years + 12.0 years

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Critical Data

Corneal Power

“Optical” Axial Length

Horizontal “White-to-White”(11.7) AC angle = WTW + 1.0 (12.7)

Sulcus = WTW + 1.5 (13.2)

Bag = WTW – 1.0 (10.7)

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CONCLUSION

Eye Model must include

NINE

types of eyes not only

THREE

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CONCLUSION: 9 EYES

Ant

erio

r S

egm

ent S

ize

Axial LengthShort Normal Long

Large

Normal

Small

Megalocornea Large Eye

+ axial Megalocornea Buphthalmos

hyperopia Megalocornea

+ axial myopia

axial hyperopia normal axial myopia

Small eye Microcornea

Nanophthalmia Microcornea + axial opia

(20%)

(10%)(2%)

(2%)

(80%) (96%) (90%)

(0%)

(0%)

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Relative Importance ofPredictors for ELP

Axial Length 100 Average K 76 Horizontal WTW 24 Refraction 18 ACD 8 LT 7 Age 1

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15 20 25 30 35

-20

0

20

40

60

80

100

Axial Length (mm)

IOL

Pow

er (

D)

Small Ant. Seg.

Normal Ant. Seg.

Large Ant. Seg.

EMMETROPIC IOL POWER

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THE HOLLADAY 2 FORMULA

More Measurements

More Accuracy

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RESULTS

New Holladay 2:

Normal eye: 50% + 0.40 D

Unusual eye: 50% + 0.80 D

Previous results:

Normal eye: 50% + 0.50 D

Unusual eye: 50% + 5.00 D8/26/2016 JTH 34

FORMULA PERFORMANCE

15 20 25 300

1

2

3

4

5

6

Axial Length (mm)

Mea

n A

bsol

ute

Err

or (

D)

Holladay 1

Hoffer Q

SRK/T

Holladay 2

N = 997

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CONCLUSIONS

Prediction Errors in Short Eyes:significantly improved by more measurements

Prediction Errors in Long Eyes:due to bad Axial Lengths, B-Scan

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Myopic Staphyloma

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Subtractfrom Ascanmeasured

Axial Length~ 0.8 mm

Zeiss - IOL Master - 2000Zaldivar-Holladay JCRS May 2000

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J Cataract Refract Surg 2011; 37:2018–2027

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Linear Regression to compensate for AVERAGE Index of Refraction in Long Eyes

Measured 36 34 mm

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Zeiss-Humphrey IOL MasterLenStar

Difficult CasesAsteroid Hyalosis (vit. debris)Extreme Length (26.5 mm)

Uses Average Index Too LongExtreme Short (< 21 mm)Pseudophakic EyesSilicone in Vitreous

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orizontal Angle & Alpha & Kappa

PCVA

< Κ

Angle Kappa on IOL Master, LenStar and penlight ~ 0.33 mm

If > 0.70 mm then concern!

●Karhanová M, Marešová K, Pluháček F, Mlčák P, Vláčil O, Sín M. Cesk Slov Oftalmol. The importance of angle kappa for centration of multifocal intraocular lenses. 2013 Jun;69(2):64-8. [Article in Czech]● G Prakash, DR Prakash, A Agarwal, DA Kumar, A Agarwal and S Jacob. Predictive factor and kappa angleanalysis for visual satisfactions in patients with multifocal IOL implantation. Eye (2011) 25, 1187–1193

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Horizontal Angle & Alpha & Kappa

OC

PC

VA

< α

< Κ

BEST CENTRATIONOF IOL

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LENSTAR – HAAG-STREIT

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IOL MASTER 500 – ZEISSVersion 7.70

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IOL MASTER 500 – ZEISSVersion ≥ 7.10

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IOL MASTER 700 – ZEISSVersion ≥ 1.1

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Horizontal Angle & Alpha & Kappa

OC

PC

VA

< α

< Κ

BEST CENTRATIONOF IOL

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Data ScreeningMonocular and Binocular

Using Mean and St. Dev. an exact p-value for each measurement can be calculated

Any measurement beyond two Std. Dev. from the mean should be double checked (p<0.05)

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Data ScreeningMonocular and Binocular

Monocular: AL = 19.75 mm

p = 0.001

Binocular: Kright - Kleft = 1.5 D

p = 0.0005

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Cataract Surgery …

IOL Power Calculations

Following Refractive

Surgery8/26/2016 JTH 52

Preoperative Assessment

Endothelial Cell Count

Pachymetry

Direct Ophthalmoscope @ 16”

Corneal Topography

Determining Corneal Power

IOL Calculation

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Corneal Power Decision Tree

SD > 0.20 D

ToPography4.5 mm Zonal K

Ref Sx, KC, PMD, … ?

ToMography4.5 mm Zonal K

Toric?

SD < 0.20 D

H2, Olsen, Barrett Formula

(7 variables)

Exact Toric CalcATR Adjustment

Keratometry Dry Eye?

Treat > 6 wks

Exact Toric Calcw Back Surface

Yes

No

Yes

No Yes

70% of cases

No

SD > 0.03 mm

SD < 0.03 mm

No dropsBlink, Blink, …

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K = 44 D

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IOL Master LenStar2.5 mm 1.7 & 2.3 mm

K = 44 D8/26/2016 JTH 58

Astigmatism Measurementfor a 44 D Cornea

Manual Keratometer 3.2 mm Diameter

IOL Master* Keratometer 2.5 mm Diameter

LenStar† Keratometer 2.35 & 1.65 mm Diameters

(Average 2.0 mm Diameter)

* Carl Zeiss Meditec AG, Goeschwitzer Str. 51-52, 07745 Jena, Deutschland

†  Haag-Streit AG, Gartenstadtstrasse 10,3098 Koeniz, Switzerland

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Ring Diameteraffects Keratometry

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If SD for K’s> ± 0.20 D (> ± 0.030 mm)

Test for Dry Eye

ToPography/ToMography

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Initial Visit 6 wks after Dry Eye Rx

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If SD > ± 0.20 D (> ± 0.030 mm)

Not Dry Eye

ToPography/ToMography

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Corneal Power afterLASIK, PRK, RK

Ideally, Calculation from both surfaces …

Calculation from Prior Data Trial Hard Contact Lens Corneal Topography Automated Keratometry Manual Keratometry

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Corneal Power afterLASIK, PRK, RK

Methods listed in order of reliability

Methods 3, 4 and 5 almost always exceed true power & result in hyperopic error

Use lowest reliable value

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Always Topography/Tomography if Correcting

Astig

To determine if REGULAR and does not change radially

Tomography can confirm if posterior astig is WTR (~ 0.22D)

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Never Perfect Bow Tie43.5 @ 105 & 41.2 @ 15

ASTIG = +2.3 @ 10544.8 @ 96 & 40.6 @ 6ASTIG = +4.2 @ 96

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ToMography: Measures Total Power andTotal Astigmatism of Lenticle

ToPography: Measures Front SurfacePower of Lenticle and then uses backradius of 0.82 of front radius forTotal Power and can ADD 0.22 DATR for Total Astigmatism

Keratometry: Measures FrontSurface Ring or annulus Power ofLenticle (nominal 2.0 to 3.2 mm for44 D cornea) then uses back radius of0.82 of front Radius for Total Power. ShouldADD 0.22 D ATR for Total Astigmatism.

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Note: 3.0 mm Mean Zonal Power = 43.00 D3.2 mm Sim K = 43.75 DNever use Sim K’s … same as keratometer

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4 mm OZ with 6 cuts ~~ - 4.00 D

ADVANCED IOL CALCULATIONS 2016

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3 mm pinhole

Rigid Contact Lens

Trial Frame

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1. Calculation from Prior Data(Pre K & Δ MR known)

Pre KR Mean K = 44.00 D

Change in SEQ Ref = -4.50 D

Calc Mean K = 39.50 D

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2. Calculation from Prior Data(Post Std. K’s & Δ MR only)

Post Mean K = 40.58 D

Change in SEQ Ref = -4.50 D

STD K’s: -0.24 * SEQ = -1.08

Calc Mean K = 39.50 D

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3. Calculation from Prior Data(Post Ctr Top Power & Δ MR only)

Post Mean K = 40.27 D

Change in SEQ Ref = -4.50 D

Ctr Top: -0.15 * SEQ = -0.77

Calc Mean K = 39.50 D8/26/2016 JTH 81

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4. Trial Hard Contact Lens(Rigid Contact lens only)

Plano HCL Base Curve = 41.50 D

SEQ Ref without CL = +0.50 D

SEQ Ref with CL = -1.00 D

Front K = 41.50 - 1.50 = 40.00 D

40.00 D – 10% (4.50) = 39.50 D

Mean K = 39.50 D 8/26/2016 JTH 83

Post-operative

Initial Hyperopic Shift

Long Term Hyperopic Drift

ATR Astigmatism Drift

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If Posterior to Anterior Radius Ratio ?

ToMography

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Accuracy of EKRPrior

Sx

STD 4.5

(D)LASIK 0.56

RK 0.94

Holladay JT, Hill WE, Steinmueller A. Corneal Power Measurements Using Scheimpfl ug Imaging in Eyes With Prior Corneal Refractive Surgery. J Refractive Surgery 2009:25:862-868. (October 2009 Issue of J Refr Surgery)

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J Cataract Refract Surg Feb 2015; 41:339–347

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Asymmetric Bowtie Early Keratoconus Post LASIK

Normal LASIK RK

41 to 44 D3 D Range

36 to 41 D5 D Range

32 to 45 D13 D Range

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Summary Optimal Zone LASIK: 4.5 mm RK: 5.0 mm Customize for small/large pupils

Accuracy LASIK: 0.56 D RK: 0.94 D

Error on MYOPIC side

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IOL CALCS in Keratoconus

Corneal is Bifocal

Patient does not look through cone for distance (may use at 10 cm as magnifier

Look at Power Distribution

Use Paracentral Power

(65% Mean Power) 8/26/2016 JTH 111

Keratoconus #1

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Keratoconus #1

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Keratoconus #1Keratoconus #1

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`Keratoconus #1

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Keratoconus Calculation #1OS

Used Km = 46.5 D => +1.00 D

Should have used 65% Mean 45.5 D => plano

should have targeted -0.50 D

(-0.50 always better than +0.50)

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IOL Calcs Using Axial Length

Cataract or Clear Lens Removal Primary Piggy-Back IOL’s

Multifocal IOL’s

Toric IOL’s

Silicone in Vitreous Compartment

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Axial Length Measurements

Phakia AL1555

Aphakia AL1532

Pseudophakia PMMA AL1532 + 0.4

Silicone AL1532 - 0.6

Acrylic AL1532 + 0.2

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Primary Piggy-Back IOL’s

Current Formulas are very inaccurate

ELP underestimated due to AL

Back lens displaced posteriorly

Severe hyperopic errors (+5 D) 8/26/2016 JTH 127

Primary PIGGY-BACKINTRAOCULAR LENSES

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Polypseudophakia

Up to 4 IOL’s

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PIGGY-BACKINTRAOCULAR LENSES

J.T. Holladay James P. Gills

Jane Leidlein Myra Cherchio

“Achieving Emmetropia In Extremely Short Eyes With Two Piggy-Back Posterior

Chamber Intraocular Lenses.”

Ophthalmology Journal. Vol. 103.

July 1996 Blue Journal”

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Primary Piggy-BackComplications

AcrylicInterlenticular membrane3 to 5 D hyperopic shift @ 3 yr

SiliconeInterlenticular membraneFlat Spot

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Minimizing Prediction Error

Holladay 2 Formula

Personalize Constant

Prediction Error vs. IOL power

Constants for Sub-groups Axial Length, K’s and Refraction

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Toric IOL’s

Current Formulas do not work because calculate different ELP for steep and flat meridian

Predicted ELP must be the same for each meridian --only one IOL position

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Toric IOL’s

Calculate IOL power for steep and flat meridian using same ELP

Difference in IOL powers is the toricity necessary to completely correct corneal astigmatism

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Ideal Toric IOL Calcs

Accurate corneal power and astigmatism … repeat is SD > 0.020 D (0.030 mm)

Exact Toric Calculator (not a constant ratio of corneal astigmatism to toricity (1.46)

Proper Surgically Induced Astigmatism (SIA) for incision location and magnitude and axis of PreOp astigmatism … must account for ATR over 3 to 6 months PostOp

Results will be greater than 80% within 0.50 D

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Toric IOL’s Always choose toricity to

undercorrect cornealastigmatism – WRONG!

LEAVE MIN RESIDUAL CYL!

Eg: Steep calc yields 24.0 DFlat calc yields 27.0 D

Ideal Toricity is 3.0 D

(Use 24.0 D with < 3.0 D of toricity)

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Never Perfect Bow Tie43.5 @ 105 & 41.2 @ 15

ASTIG = +2.3 @ 10544.8 @ 96 & 40.6 @ 6ASTIG = +4.2 @ 96

TORIC IOL Calculations

Commercial Calculators use a constant ratio (1.46) for the corneal cylinder to the IOL cylinder

Exact Calculation depends on IOL SEQ Power and ELP… to correct 2D of corneal astigmatism

10 D IOL => 3.5 D Cylinder 22 D IOL => 2.9 D Cylinder 34 D IOL => 2.4 D Cylinder

A 1.1 D difference from 10 D to 34 D!

Toric CalculatorsExact Approximate

• Holladay On-line

• AMO Express On-line

• Holladay IOLConsult

8/26/2016 Jack T. Holladay, M.D. 156

• Alcon On-line

• B & L On-line

• Barrett On-line

8/26/2016 Jack T. Holladay, M.D. 158

Dioptric Error vs. Angular Errorfor a 1.00 D of astigmatism

Angle Error ( ) Dioptric Error (D)

Dioptric Error = 2 * Cyl * sin (angular error)

% Error0° 0.00 0%

15° 0.52 52%

30° 1.00 100%

45° 1.41 141%

60° 1.73 173%

75° 1.93 193%

90° 2.00 200%

8/26/2016 Jack T. Holladay, M.D. 159

Abulafia A, Hill WE, Franchina M, Barrett GD. Comparison of Methods to PredictResidual Astigmatism After IOL Implantation. J Refract Surg. 2015;31:699-706

8/26/2016 Jack T. Holladay, M.D. 160

Abulafia A, Hill WE, Franchina M, Barrett GD. Comparison of Methods to PredictResidual Astigmatism After IOL Implantation. J Refract Surg. 2015;31:699-706

ADVANCED IOL CALCULATIONS 2016

JACK T. HOLLADAY, MD, MSEE, FACS Page 21 of 27

8/26/2016 Jack T. Holladay, M.D. 161

Abulafia A, Koch DD, Wang L, Hill WE, Franchina M, Assia EI, Franchina M, Barrett GD. New regression formula for toric IOL calculations. J Cat Ref Surg. 2016; 42:663-671 Surgically Induced Astig (SIA)

• Critical to use correct value

• Not ~0.35 D WTR for small (2.5 mm), near-clear temporal incision

• Better to use Zero SIA and Baylor Nomogram– ↓ WTR (steep 90) by ONE Toric Size (T4 T3)

– ↑ ATR (steep 180) by ONE Toric Size (T3 T4)

– No change in Oblique

• Equivalent to ADDING ~ 0.51 D ATR as SIA

Wang/Koch Recommendation

• WTR: Subtract 0.6 D from measured

• ATR: Add 0.2 D to measured

• Oblique: No change

Equivalent to:

SIA = 0.2 + 0.4 sin2(Steep axis of astigmatism)

0 = 0.2@90 45 = 0.4@90 90 = 0.6@90

8/26/2016 Jack T. Holladay, M.D. 163

SIASteep Axis ( ) Magnitude (D) Axis of Flattening ( )

0 0.20 90

10 0.21 90

20 0.25 90

30 0.30 90

40 0.37 90

45 0.40 90

50 0.43 90

60 0.50 90

70 0.55 90

80 0.59 90

90 0.60 90 164

8/26/2016 JTH 165

Additional Factors (Wang/Koch)

Posterior cornea has ~ 0.25 D WTR

WTR decays ~ 0.50 D WTR

ATR decays ~ 0.00 D ATR

Result: ↓ K WTR by 0.75 D

↑ K ATR by 0.25 D

x

ADVANCED IOL CALCULATIONS 2016

JACK T. HOLLADAY, MD, MSEE, FACS Page 22 of 27

x

8/26/2016 JTH 168

Right Eye Left Eye

ATR WTR

8/26/2016 Jack T. Holladay, M.D. 169

www.hicsoap.com CALCULATORS TAB

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Post Op Toric Calculators

Holladay IOL Consultant www.hicsoap.com

Berdahl & Hardten Toric IOL Calculator www.astigmatismfix.com

8/26/2016 JTH 175

Two Sources of Error

IOL misaligned (wrong axis)

IOL Toricity wrong (over/under)

Or

Both

8/26/2016 JTH 176

ADVANCED IOL CALCULATIONS 2016

JACK T. HOLLADAY, MD, MSEE, FACS Page 23 of 27

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PREOP 6 D Toric IOLLEFT

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PREOP 6 D Toric IOL -- ODLEFT

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PREOP 6 D Toric IOL -- OSLEFT

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Mean Dev = -0.72 D

8/26/2016 JTH 182

Silicone in Vitreous Cavity

Use Convexo-Plano IOL to minimize effect of Silicone(add 3 D to calculated IOL)

If Biconvex IOL(add 6 D to calculated IOL)

When Silicone removed -- 2 to 5 D of induced myopia

8/26/2016 JTH 183

IOL Calculations

using a

Refractive Formula

(ignore axial length)

ADVANCED IOL CALCULATIONS 2016

JACK T. HOLLADAY, MD, MSEE, FACS Page 24 of 27

8/26/2016 JTH 184

IOL Calculation without AL

Secondary AC or PC IOL for Aphakia

Secondary Piggy-Back AC or PC IOL for Pseudophakia

Primary AC IOL in Phakia

8/26/2016 JTH 185

REFRACTION FORMULA

IOL

PreRxV

KELP

DPostRxV

KELP

13361336

10001000

13361336

10001000

8/26/2016 JTH 186

Secondary Piggy-Back IOL’sIndications

Intolerable Pseudophakic Refractive Error

8/26/2016 JTH 187

Refractive Surprises

Previous RK, PRK, LASIK

Bad axial length - short/long

Mislabeled IOL

Axially displaced

Misc.

8/26/2016 JTH 188

Secondary Piggy-Back CalcAdvantages over Exchange

Mislabeled IOL irrelevant

Less risk to capsule or zonules

Mismeasured AL irrelevant

No AP shift of existing IOL

Fewer unknown variables8/26/2016 JTH 189

ADVANCED IOL CALCULATIONS 2016

JACK T. HOLLADAY, MD, MSEE, FACS Page 25 of 27

8/26/2016 JTH 190 8/26/2016 JTH 203

8/26/2016 JTH 204

IOL Power Calcs for Phakic IOLs

(2º Piggy-Back & IOL Exchange after

Refractive Surprise)

Jack T. Holladay, MD, MSEE, FACSClinical Professor of Ophthalmology

Baylor College of MedicineHouston, Tx 8/26/2016 JTH 205

Phakic IOL’s

Compete with corneal refractiveprocedures for high myopiaand med & high hyperopia

ACL, ICL or Iris Clip ?

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Phakic IOL’s(Secondary Piggy Back IOL’s)

Refraction

Formula

ADVANCED IOL CALCULATIONS 2016

JACK T. HOLLADAY, MD, MSEE, FACS Page 26 of 27

8/26/2016 JTH 209

Phakic IOL CalculationInput Variables

Refraction and Vertex

Keratometry

Desired Refraction

Predict ELP (ACD)Effective Lens Position

8/26/2016 JTH 210

REFRACTION FORMULA

IOL

PreRxV

KELP

DPostRxV

KELP

13361336

10001000

13361336

10001000

Holladay, J.T.: "Refractive Power Calculations for IntraocularLenses in the Phakic Eye." American Journal of Ophthalmology.

Volume 116:63-66, July 1993.

8/26/2016 JTH 211

Phakic IOL CalculationInput Variables

Refraction and Vertex

Soft Contact Lens @ Vtx = 0

w Small Over-Refraction (< 2 D)is most accurate.

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Effective Lens Position (ELP)OLD ACD

Verisye Avg ELP = 4.27 mm

AACD (20 y/o) = 3.60 mm

AACD + 0.67 mm = ELPx

8/26/2016 JTH 213

Effective Lens Position (ELP)OLD ACD

Visian ICL Avg ELP = 4.00 mm

AACD (20 y/o) = 3.60 mm

AACD + 0.40 mm = ELPx

8/26/2016 JTH 214

Effective Lens Position (ELP)OLD ACD

Visian ICL Avg ELP = 4.00 mm

ADVANCED IOL CALCULATIONS 2016

JACK T. HOLLADAY, MD, MSEE, FACS Page 27 of 27

8/26/2016 JTH 215

Phakic IOL Calculations

+ IOL’s to Specs ~ 1.5 to 1

- IOL’s to Specs ~ 1.0 to 1

Approximation only

8/26/2016 JTH 220

8/26/2016 JTH 222 • • • • The International Society of Refractive Surgery • • • •

April 23,2002Sydney

Thank you !

WWW.AAO.ORGAMERICAN ACADEMY OF OPHTHALMOLOGY

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