Addison’s disease final ppt
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Addison’s DiseaseArielle Howard
Ariel Baker Brittany Martin
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O PATHOPHYSIOLOGY• A chronic condition that results from the
partial or complete destruction of the adrenal cortex
• Causes deficiencies of the adrenocortical secretions: glucocorticoids, sex hormones, and mineral corticoids
Cortisol, Aldosterone, Androgens and Estrogens
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Prevalence and Risk FactorsO Addison’s disease is
rare O 1/100,000 peopleO Effects all age groups
(More common between ages 30 – 50)
O More prevalent in women but can effect men as well
O Primary Adrenal insuff.O Idiopathic Autoimmune
Dysfunction (majority)O TuberculosisO HIV, CancerO AdrenalectomyO Fungal Infections
O Secondary Adrenal insuff.O Steroid withdrawalO HypophysectomyO Pituitary neoplasm
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CLINICAL FINDINGSSubjective Objective
O FatigueO Muscle weaknessO Muscle/joint painO Salt cravingO NauseaO Anorexia
(decrease in appetite)
O Irritability
O HyperpigmentationO HypotensionO HypoglycemiaO HyperkalemiaO VomitingO DiarrheaO Mouth lesionsO Decrease in body
hair
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OCORTISONE• Action: Inhibits multiple inflammatory
cytokines; produces multiple glucocorticoid and mineral corticoid effects.
• Adrenal insufficiency: 25-300mg PO QD-QOD
• Major side effects: Circulatory collapse, thrombophlebitis, embolism, necrotizing angiitis, CHF, GI hemorrhage, pancreatitis, thrombocytopenia
• Nursing Considerations: Monitor BP; weight; 2hr postprandial glucose; chest x-ray if prolonged tx; Electrolytes (k+); I&O ratio (decreasing output and increasing edema); Plasma cortisol levels (norm: 6-23mcg/dL); signs of infection (drug masks infection); cardiac symptoms (edema, HTN)
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Treatments MedicationsO Fludrocortisone
O Aldosterone replacement
O Oral corticosteroidO Hydrocortisone/
PrednisoneO Cortisol
replacementO Oral or injection:
O INJECTION given when patient is experiencing N/V or during an Addisonian Crisis
*Hormone replacement is used to correct the insufficient levels of steroids the adrenal
glands can not produce.* Increase in sodium
intake*Life long drug maintenance is
required .
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Nursing Diagnosis /Considerations
O Electrolyte Imbalance r/t vomiting and diarrhea AEB hyperkalemia and hyponatremia
O Imbalanced nutrition: less than body requirements r/t anorexia AEB 20% decrease in weight and inadequate food intake
O Monitor patient frequently for dysrhythmias
O administer NaCl IV to increase sodium
O Administer Insulin or Kayexalate
O Administer an antiemetic as tolerated by the patient
O Provide high calorie snacks and finger foods
O Daily weightO Nutritional supplements
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Patient EducationO Increase salt intake during hot weather and
heavy exerciseO Never skip a dose. This could lead to an
Addisonian crisisO Learn to recognize the symptoms of an
Addisonian crisis. Ex: pain in lower back, severe vomiting and diarrhea , extreme weakness, fainting. Contact physician immediately.
O Wear Med alert tag O Frequently monitor weight O Reframe from stressful activities
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Pertinent Nursing •Monitor for fluid deficits and hypernatremia •Monitor and treat hyperkalemia
Obtain serum potassium and ECG Administer sodium polystyrene sulfonate (Kayexalate),
insulin, calcium, glucose, and sodium bicarbonate •Monitor and treat hypoglycemia
Perform frequent neurologic checks, monitor for S/S of hypoglycemia, and check serum glucose
Administer food and/or supplemental glucose• Maintain a safe environment
Provide assistance ambulating, raise side rails and prevent falls by keeping floors clear
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Addison’s Pictures
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N-Clex QuestionO A nurse is reviewing serum laboratory
results for a client who has Addison’s disease. Which of the following findings should the nurse expect?
Soduim 130mEg/L Potassium 5.1 mEg/L Calcium 10.6 mEg/L Magnesium 2.5 Meg/L Glucose 65mg/dL Phosphorus 2.4 mg/dL
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N-Clex AnswerO Sodium 130 (135-145)O Potassium 5.1 (3.5-5.0)O Calcium 10.6 (8.0-10.5)O Glucose 65 (70-110)
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ReferencesO Lewis, S. M. (2011). Medical-surgical
nursing: Assessment and management of clinical problems. St. Louis, Mo: Elsevier/Mosby
O ATI RN Medical Surgical Nursing Edition 8.0 (Chapter 94)
O www.cdc.govO http://jama.jamanetwork.com/article.
aspx?articleid=201884