Acupuncture n Stroke (1)

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    ACUPUNCTURE

    & STROKE

    Prepared by: Tilda Teo

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    Does Acupuncture

    really work to help

    stroke victims improve?

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    Control of Pain

    Improve motor functions

    Increase sensation

    Improve neurological functions in stroke

    Respiratory disorders

    Strengthening immune system

    Emotional and psychological disorders

    Musculoskeletal disorders (ie: frozen shoulder, OA)

    ETC

    Benefits of Acupuncture

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    insertion of solid filiform acupuncture needles into the skin at specific

    points on the body to achieve a therapeutic effect

    encourage natural healing, improve mood and energy, reduce or relieve

    pain and improve function of affected areas of the body

    dull, heavy, or aching feeling often occurs when the needle is inserted

    needles are left in place for 15-30 minutes

    What is Acupuncture?

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    Terminologies

    Qi : Vital energy flows through the channels of Meridiens and regulatesbodily functions

    Meridiens : Transmission lines of communication among the organs and the

    body

    Acupoints : Locations on the body along meridiens

    Manual-Acupuncture : Acupuncture performed at acupointsMechanical

    Stimulation

    Electro-Acupuncture : Needles which are electrically stimulated by various

    frequencies and voltages Electrical Stimulation

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    Effect of acupuncture on

    motor recovery in acutestroke patients

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    Effect of EA and MA on motor recovery in stroke

    patients-- Acute

    A Cochrane review

    review of 14 trials

    insufficient evidence to determine the benefits of

    acupuncture

    due to the small sample size

    (Zhang et al 2005)

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    Johansson et al (2001)Acupuncture and

    Transcutaneous Nerve Stimulation in Stroke Rehabilitation. A RCT.Hypotheses :

    1) Sensory stimulation by

    acupuncture (including EA)

    improves motor function and/or

    ADL after stroke

    2) Sensory stimulation by high-

    intensity low-frequency TENS,

    that induces muscle contractions

    comparable to those induced byEA, improves motor function

    and/or ADL after stroke

    Outcome Measures :

    1) Barthel Index

    2) Rivermead Mobility Index

    3) Nine Hole Peg Test

    4) 10m Walk test

    5) Nottinghan Health Profile

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    Johansson et al (2001)Acupuncture and

    Transcutaneous Nerve Stimulation in Stroke Rehabilitation. A RCT.

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    Johansson et al (2001)Acupuncture and

    Transcutaneous Nerve Stimulation in Stroke Rehabilitation. A RCT.

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    Johansson et al (2001)Acupuncture and

    Transcutaneous Nerve Stimulation in Stroke Rehabilitation. A RCT.Results :

    No clinically important or statistically

    significant differences were

    observed between groups for

    any outcome variables.

    Discussion :

    Although stimulation in the control

    group was subliminal, theremight be some degree of

    sensory input .

    Placement of electrodes on the skin

    are likely to stimulate

    mechanosensitive nerve fibers.

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    Sze et al (2002)Does Acupuncture have additional

    value to standard poststroke motor rehabilitation?Aims:

    1) Examine whether acupuncture

    has additional value to standard

    poststroke motor rehabilitation.

    Outcome Measures :

    1) Fugl-Meyer Assessment of

    Physical Performance2) Barthel Index

    3) Functional Independence

    Measure

    4) Abbreviated Mental Test

    5) NIH Stroke Scale

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    Sze et al (2002)Does Acupuncture have additional

    value to standard poststroke motor rehabilitation?

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    Sze et al (2002)Does Acupuncture have additional

    value to standard poststroke motor rehabilitation?

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    Sze et al (2002)Does Acupuncture have additional

    value to standard poststroke motor rehabilitation?Results :

    1) No statistically significant

    differences were observed

    between the 2 arms for any

    outcome measures at week 10.

    Discussion :

    1) Comparability assessment

    between the 2 groups was basedon admission BI, and not on the

    TCM classification of stroke and

    its characteristics.

    2) Flexibility of selecting acupoints

    leading to poor standardization

    or protocol

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    Effect of EA and MA on motor recovery

    in stroke patients-- Acute

    Study Subject Rx Outcome

    measures

    Finding

    Sze et al

    (2002)

    106 acute

    stroke

    moderate to

    severe motordisabilities

    MA

    Flexible acupoints

    30min

    35X 8 week

    BI

    FIM

    FMA

    No further improvement

    Compare with patients

    solely involved in motor

    rehabilitation programme

    Johanss

    on et al

    (2001)

    150 acute

    stroke

    moderate to

    severe

    functionalimpairment

    EA and MA

    Fixed acupoints

    30 min

    2 X /week

    10 weeks

    BI

    RMI

    9 holes Peg

    test

    time tocomplete a

    10m walk

    No further improvement

    No additional benefit to

    conventional stroke rehab

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    Effect of acupuncture on

    motor recovery in chronicstroke patients

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    Wayne et al (2005)Acupuncture for Upper-Extremity Rehabilitation in chronic stroke: A randomized sham-

    controlled studyAims:

    1) Examine whether active

    acupuncture improves UE ROM,

    spasticity and motor function.

    2) Assess whether active

    acupuncture improves ADLs,

    QOL and mood

    Outcome Measures :

    1) Fugl-Meyer Assessment

    2) Modified Ashworth Scale

    3) UE ROM

    4) Grip Strength

    5) Barthel Index

    6) Nottingham Health Profile

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    Wayne et al (2005)Acupuncture for Upper-Extremity Rehabilitation in chronic stroke: A randomized sham-

    controlled study

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    Wayne et al (2005)Acupuncture for Upper-Extremity Rehabilitation in chronic stroke: A randomized sham-

    controlled study

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    Wayne et al (2005)Acupuncture for Upper-Extremity Rehabilitation in chronic stroke: A randomized sham-

    controlled studyResults :

    1) Intention-to-treat analyses found

    no statistically significant

    differences in outcomes between

    active and sham acupuncture

    groups.

    2) Analyses of protocol-compliant

    subjects showed significant

    improvements in wrist spasticity,both wrist and shoulder ROM

    and improvement trends in UE

    motor function.

    Discussion :

    1) Use of sham blunt-tipped needle

    that did not penetrate the skinwas a effective concealable

    control.

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    Schaechter et al (2007)Correlated change inUpper Limb Function and motor cortex activation after verum and

    sham acupuncture in patients with chronic stroke.Aims:

    1) Examine whether changes in

    brain activation differs in stroke

    patients treated with verum or

    sham acupuncture.

    Outcome Measures :

    1) MR image acquisition

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    Schaechter et al (2007)Correlated change inUpper Limb Function and motor cortex activation after verum and

    sham acupuncture in patients with chronic stroke.

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    Schaechter et al (2007)Correlated change inUpper Limb Function and motor cortex activation after verum and

    sham acupuncture in patients with chronic stroke.Results:

    1) There is a significant positive

    correlation between changes in

    function of the affected UL

    (spasticity and ROM) and

    activation of ipsilesional motor

    cotex.

    Discussion :

    1) Acupuncture helps restore activity

    along spared descending motorpathways, thereby improving

    cortical modulation of lower

    motor neuron excitability

    involved in spasticity and ROM.

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    Effect of EA and MA on motor recovery

    in stroke patients-- ChronicStudy Subject Rx Outcome

    measures

    Finding

    Wayne et al

    (2005)

    33 chronic

    stroke

    severe to

    moderate

    upper limbfunctional

    disabilities

    EA + MA

    Flexible yet

    standard

    Acupoint

    20-30 minutes 2X/ week

    a mean period

    of 10.5week

    UE motor

    function

    FMA

    Spasticity

    MASGrip strength

    ROM

    ADL

    QOL

    Mood

    Active acupuncture:

    A significant improvement:

    Ashworth wrist score (p

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    Effect of EA and MA on motor recovery

    in stroke patients-- summary

    Acute:

    Do not support additional benefit for patients

    receiving conventional stroke rehabilitation Chronic:

    May have a role in improving upper limb function

    Small sample size

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    So does Acupuncture

    really work to help

    stroke victims improve?

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    Clinical Implication

    The safety

    Only 1 study noticed a harmful effect of EA (Sui, Lo, Leung 2004b)

    inappropriate acupoint used

    Acupoint:

    animal studies a few fixed acupoints were used

    Human highly recommendable that a different set of acupuncture points

    to be used for individual patients based on their presentation instead of using

    fixed prescription acupoint for all patients.

    (Sze et al 2002)

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    Conclusion

    Effects of MA and EA on motor recovery

    No strong evidence in further enhancing motor recovery in

    chronic and acute stroke patients.

    Further studies if MA or EA treatment able to improve

    functional status

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