Aconcagua -...
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Aconcagua:
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Oxygen Research OverviewLeveraging Biology to Enhance Performance
Genetics and Oxygen Efficiency
Oxygen Deprivation Training
Cognition in Low Oxygen Environments
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Early Research
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Human Gene for Physical Performance
VO2 max = 65 ml / kg / minute
Montgomery, Marshall, Hemingway, Myerson, Clarkson, …, Humphries, Nature, 1998
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VO2 max
VO2 max = 65 ml / kg / minute
VO2max trainability is 47% heritableBouchard et al., 1999 (HERITAGE Study)
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Air Force Applications
Warfighter Optimization
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Training Performance Analysis V
O2 M
ax (m
l/kg/
min
) Del
ta P
RE
V P
OS
T
Different Participants Sorted Lowest to Highest Response
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Genetic Model for Trainability
% Increasein
Oxygen Efficiency
10
20
30
40
Low Total Genotype Score
Medium Total Genotype Score
High Total Genotype Score
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Air Force Applications
Warfighter Optimization
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Oxygen Research OverviewLeveraging Biology to Enhance Performance
Genetics and Oxygen Efficiency
Oxygen Deprivation Training
Cognition in Low Oxygen Environments
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Oxygen Research OverviewLeveraging Biology to Enhance Performance
Genetics and Oxygen Efficiency
Oxygen Deprivation Training
Cognition in Low Oxygen Environments
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Personalized Training
➢ MUSCLE TYPE: Sprinter/Power
➢ VARIANT: ACTN3
➢ Your fast-twitch muscle fibers have the alpha-actinin-3 protein
➢ RECOMMENDATION:
High-Intensity Interval Training
✓ Functionalized Circuits✓ Heart-Rate Biofeedback
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Air Force Applications
Warfighter Optimization
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Integrity ★ Service ★ Excellence
Enhancing Human Systems ThroughTranslational Neuroscience
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