ACIS ® III Image Analysis Robert Carlson Manager, Imaging Systems *Accurate *Efficient *Consistent...
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Transcript of ACIS ® III Image Analysis Robert Carlson Manager, Imaging Systems *Accurate *Efficient *Consistent...
ACISACIS®® III IIIImage AnalysisImage Analysis
Robert Carlson
Manager, Imaging Systems
*Accurate *Efficient *Consistent
*Easy to use
DAKO: 40 Years Experience in AP MarketplaceFrom Antibodies to System Solutions
1966 Antibody Production
1995 TechMate™
2000 Dako Autostainer™
2002 Artisan™
2006 ACIS® III
2007 The Dako Link Solution
Addressing Your Challenges
Cost and Productivity Turn Around Time Quality
Utilize labor time more efficiently
Simplify ordering processes
Streamline workflow
Eliminate redundant tasks
Process simultaneously
Reduce repeats
Improve consistency
Implement cutting-edge technologies
ACISACIS®® III is Accurate III is Accurate
Proprietary, color-based image analysis software combined with Whole Slide Scanning automated microscopy
FDA Cleared Applications
HercepTestTM for HER2
ER
PR
Additional applications
Generic applications (Membrane, Nuclear, Microvessel Density, Ploidy, Rare Event)
Tissue Micro Array (TMA)
Flexible solutions to meet unique research needs
ACISACIS®® III is Efficient III is Efficient
Technician Operation
Automated calibration (10 min., once every 24 hours)
Accessioning
Dako LINK software Integration
ACIS III accessioning screen
Automated processing of slides
High capacity (100 slides)
Continuous access 24 hours a day
Immediate access to digital slides for scoring
Analysis of digital slides by pathologist
Need a quick consult or second opinion…use Dako EyeShareTM
Report generation by pathologist or technician
ACISACIS®® III is Consistent III is Consistent
Gold Standard Calibration
Daily, one-touch calibration ensures proper focus, color balance and light intensity
Calibration does not require additional pathologist time
ACIS III improves inter-observer reproducibility with consistent stain intensity scoring
Proper calibration helps ensure laboratory results are consistent
4-tab Dako software format
Accessioning
Microscope
Analysis
Report
Easy to use
Reduces training time
Reduces hands-on time
ACISACIS®® III is Easy to use III is Easy to useSoftwareSoftware
Dako EyeShareDako EyeShare™™
Remote Slide Viewing Software via the internet
Live Consultation
Second opinions
Teaching
Standardization
ACIS: Proven Performance: Sample Article Listing
• Most peer reviewed imaging system on market
ACIS® Selected Article BibliographyAutomated System Improves Accuracy of HER-2 Scoring. ONI, April 2001.
Ayala G, Wang D, Wulf G., Frolov A, Li R, Sowadski J, Wheeler T, Lu K, Bao L. The Prolyl Isomerase Pin1 is a Novel Prognostic Marker in Human Prostate Cancer. Cancer Research 2003; Vol. 63, 6244-6251.
Bauer KD, Torre Bueno, J, Diel IJ, Hawes D, Decker WJ, Priddy C, Bossy B, Ludmann S, Yamamoto K, Masih AS, Espinoza FP, and Harrington DS. Reliable and Sensitive Analysis of Occult Bone Marrow Metastases Using Automated Cellular Imaging. In Autologous Blood and Marrow Transplantation X: Proceedings of the 10th International Symposium (K.A. Dicke and A. Keating, eds). 2001. Carden Jennings Publishing Co., Charlottesville, VA, 672-687.
Becker S, Becker-Pergola G, Fehm G, Emig R, Wallwiener D, Solomayer E-F. Image Analysis Systems for the Detection of Disseminated Breast Cancer Cells on Bone-Marrow Cytospins. Journal of Clinical Laboratory Analysis 19:115–119, 2005.
Birner P, Ritzi M, Musahl C, Knippers R, Gerdes J, Voigtlander T, Budka H, Hainfellner J. Immunohistochemical Detection of Cell Growth Fraction in Formalin-Fixed and Paraffin-Embedded Murine Tissue. Am J Pathol 2001; Vol. 158, 1991-1996.
Summary of Key Benefits of Dako Solution
True Positive ID Support
Connectivity Optimal Staining Performance
Easy-to-Use Software