Acid peptic disease Seyed vahid hosseini Professor of surgery Department of surgery Colo-rectal...
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Transcript of Acid peptic disease Seyed vahid hosseini Professor of surgery Department of surgery Colo-rectal...
IntroductionNumber of admissions for
uncomplicated disease is falling Incidence of complications related to
NSAID use is increasing Incidence has declined by 50% in last
25 yearsSurgical intervention is rare now for
elective treatment
Medical TreatmentBiaxin 500 BID and Amoxacillin 1g BID
plus Prilosec BID all for 2 weeks.Flagyl 250 QID and Tetracyclin 500 QID
and Prilosec BID all for 2 weeks.80% heal over 6 weeks.80% recur after 1 year if H.Pylori not
treated at same time.
History of Peptic Ulcer Surgery Harberer 1882- first gastric resection for ulcer Billroth 1885- Billroth II gastrectomy Hofmeister 1896- Retrocolic anastamosis Dragstedt 1943- Truncal vagotomy Visick 1948- vagotomy and drainage Johnson 1970- highly selective vagotomy
Indications For SurgeryBleedingPerforationObstruction IntractabilitySurgical treatment is aimed at reduction
of acid production one way or anotherCure with lowest risk of complications
Open Surgical ProceduresTruncal vagotomy and pyloroplastyTruncal vagotomy and
gastrojejunostomyTruncal vagotomy and antrectomyHighly selective vagotomy
Truncal Vagotomy Resect 1-2cm of each vagal trunk on distal
esophagus. Reduces acid by 80%. Denervates parietal cells, antral pump, pyloric
sphincter mechanism. Delays gastric emptying, so need drainage. With pyloroplasty recurrence 3-10% With pyloroplasty morbidity 1-2%
Truncal Vagotomy and AntrectomyEntails distal gastrectomy of 50-60% of
stomach.Removes parietal cell mass.Requires a BI or BII reconstruction.Recurrence rate 0.6-4%Morbidity rate 0.9-1.6%
Selective VagotomyTotal denervation of the stomach from
diaphragmatic crus to pylorus.Procedure still needs drainage, but
advantage is other organs are spared, liver, gallbladder, small bowel, colon.
Highly Selective VagotomySpares nerves of Latarjet, but divides
vagal branches to proximal 2/3 of stomach.
Antral innervation is thus preserved, gastric emptying preserved, so drainage procedure unnecessary.
Recurrence rate 10-15%Lowest morbidity of all
Billroth I GastrectomyOriginally described for resection of
distal gastric ulcers.Still used in gastric cancers if radical
gastrectomy is inappropriate.Later applied in treatment of benign
ulcers.Useful for ulcers high on lesser curve,
or bleeding ulcer that needs resection.
Billroth II Gastrectomy Initially described for duodenal ulcers.Some form of vagotomy is treatment of
choice for uncomplicated DU.Ulcer heals after surgery.Useful in recurrent ulcers following
previous vagotomy.Antecolic vs retrocolic.