ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and...

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Colon ischemia ACG Clinical Guideline; Am J Gastroenterol 2015

Transcript of ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and...

Page 1: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Colon ischemia

ACG Clinical Guideline; Am J Gastroenterol 2015

Page 2: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Manifestations

Acute, reversible

Irreversible : gangrene, fulminant colitis/stricture

formation, chronic ischemic colitis

Recurrent sepsis due to bacterial translocation-in

irreversible damaged bowel

Page 3: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Pathopysiology of colon ischemia

Alterations in the systemic circulation

anatomic/functional changes in the mesenteric

vasculature

LOCAL HYPOPERFUSION AND REPERFUSION

Page 4: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

RISK FACTORS

Comorbid cardiovascular disease and diabetes

mellitus

Diseases with cardiac source of embolism

Chronic kidney diseases and COPD-increased

mortality from colonic ischemia

Thrombophylia-young patients

Surgical operations on the abdomen-especially

abdominal aortic aneurysm repair

Drugs

Page 5: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Drugs

Moderate evidence: constipation-inducing drugs,

immunomodulator drugs, illicit drugs(amphetamines,

cocaine)

Low evidence: chemotherapeutic drugs,

decongestants(pseudoephedrine), diuretics, ergot

alcaloids, hormonal therapies, psychotropic drugs,

serotoninergic drugs

Page 6: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Clinical presentation

Sudden mild abdominal pain, urgent desire to

defecate, passage within 24 hours of bright red or

marroon blood per rectum or bloody diarrhea

9.9% gangrenous colitis, 2.5% fulminant colitis

Summary statement

CI isolated to the right colon is associated with

higher mortality rates

Page 7: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Segmental nature

Left colon most affected -32.6%

Regions particularly susceptible to ischemia:splenic

flexure, sigmoid colon

Rectum-uncommonly affected (dual supply-splanhnic

and systemic)

Isolated right colon ischemia: more frequently atrial

fibrillation, coronary artery disease, chronic kidney

disease on hemodyalisis and worse outcomes

Page 8: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Recommended laboratory tests

Serologic

1. Albumin

2. Amylase

3. Complete blood count

4. Comprehensive electrolyte panel

5. CK

6. Lactate

7. LDH

Stool tests-Cl.difficile assay, culture, ova and

parasites

Page 9: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Predictors of severity(summary statements)

Decreased Hb level

Low serum albumin

Metabolic acidosis

Page 10: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Plain radiography(thumbprinting sign)

Page 11: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Imaging

CT with iv and oral contrast

Multiphasic CT angiography(suspected IRCI or AMI)

MR angiography

Splanchnic angiography

Page 12: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

CT in severe cases

Page 13: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Recommendations

CT with iv and oral contrast – first imaging modality

of choice for patients suspected for colonic ischemia

Early colonoscopy(Within 48h of presentation)

should be performed in suspected CI to confirm

diagnosis

Page 14: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Colonoscopy in the diagnosis

Early colonoscopy (within 48 h of presentation)

should be performed in suspected CI cases to

confirm the diagnosis

The endoscopic procedure should be stopped at the

distal-most extent of the disease

Contraindicated: acute peritonitis, gangrene,

pneumatosis

Page 15: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Endoscopic images

Page 16: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Endoscopic imaging

Page 17: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Histopathology

Infarction and ghost cells-pathognomonic

Other histologic signs: mucosal and submucosal

hemorrhage, edema, capillary fibrin thrombi

Page 18: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Classification of disease severity

Mild –no risk factors

Moderate- any patient with CI with three risk factors

Severe- any patient with CI with more than three risk

factors or any of the following-peritoneal signs,

pneumatosis or portal gas at imaging, gangrene on

colonoscopy, pancolonic distribution/IRCI

Page 19: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Risk factors to predict severity of colonic

ischemia

Male gender

TA<90mm

HR> 100/mi/dl

Abdominal pain without rectal bleeding

BUN>20mg/dl

Hb<12g/dl

LDH>350U/l

Na<136

WBC>15.000

Colonic mucosal ulcerations at endoscopy

Page 20: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Severity and treatment-Recommendations

1. most cases do not require specific therapy

2. surgical intervention

3. antibiotic therapy in moderate or severe disease

Page 21: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Ischemic colitis mortality index

Risk factors for perioperative mortality

1. Low output heart failure

2. Acute kidney injury

3. Subtotal or total colectomy

4. Lactate > 2.5mmol/l

5. Pre and intraoperative catecholamine

administration

Page 22: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Ichemic Colitis Mortality Risk Score

Risk factors Mortality

0 10.5%

1 28.9%

2 37.1%

3 50.0%

4 76.7%

5 100%

Page 23: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Antibiotic therapy

In moderate or severe disease

Recommendation is based upon expert opinion

considering murine models, retrospective human

studies,personal experience of experts

Broad antimicrobial regimens, 7 days

Page 24: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Management

Page 25: ACG Clinical Guideline; Am J Gastroenterol 2015 · RISK FACTORS Comorbid cardiovascular disease and diabetes mellitus Diseases with cardiac source of embolism Chronic kidney diseases

Surgical indications

Acute indications: peritoneal signs, massive

bleeding, fulminant colitis with or without toxic

megacolon, portal venous gas or pneumatosis

intestinalis, deteriorating clinical condition

Subacute indications: failure to respond to treatment

within 2-3 weeks with continued symptoms or a

protein-losing colopathy

Chronic indications: symptomatic colon stricture,

symptomatic segmental ischemic colitis