• Abstract

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Rom J Morphol Embryol. 2008;49( !: 8"#$.

Chronic tonsillitis: histological and immunohistochemical aspects.Mo%oant& 'A" )on*+& E ,*r*c* - M*tro* M An%hel*na '*olo/an S ,&tr E .Author informationAbstractOBJECTIVES:'hron*c tons*ll*t*s represents the most common *n/lammatory les*ons o/ the pharyn1 determ*n*n%n mero s local or d*stant e ol t* e compl*cat*ons. 3e dec*ded to st dy the h*stolo%*cal and espec*ally *mm noh*stochem*cal e1press*on o/ th*s patholo%y.

ATE!IA" A#$ ET%O$S:3e ha e st d*ed ""2 s r%*cal samples represent*n% tons*ls resected /rom $ pat*ents 5*th chron*c tons*ll*t*s. 6he tons*llectom*es 5ere per/ormed *n the E76 'l*n*c o/ the Emer%ency 'o nty osp*tal o/ 'ra*o a bet5een 0".0".200 ## "."2.200 . 6he processed h*stolo%*cal samples 5ere sta*ned s*n% emato1yl*n#Eos*n l*%ht %reen tr*chrom*c and ar%ental *mpre%nat*on. or the *mm noh*stochem*cal st dy 5e sed SA method 5*th '-20 '-4 R< '-$8 ant*bod*es *n order to re eal and d*//erent*ate 6# and #lymphocytes and also the macropha%es.!ES&"TS:)n all samples 5e /o nd hyperplas*a and hypertrophy o/ the lympho*d /oll*cle 5*th e1cess* e de elop*n% o/ the clear %erm*nal center as a normal react*on to ant*%ens presence. )n some cases 5e remar=ed m*crohemorrha%es and hemat*c e1tra asat*ons *ns*de the /oll*cles probably d e to the e1cess* e *r lence o/ the patho%ens ca s*n% endothel*al les*ons. 6he con> nct* e stroma 5as enr*ched *n colla%en /*bbers *n some cases or%an*?ed *n stron% /asc*cles 5*th an ob *o s tendency to d* *de the tons*ls *n lob les. 6he yo n% /*broblast*c type cells 5ere n mero s. 6he spec*/*c ret*c l*n /*bbers had a lo5 representat*on be*n% d*sor%an*?ed. 6he *mm noh*stochem*cal st dy pro ed that the clear center o/ the lympho*d /oll*cles 5as occ p*ed by #lymphocytes b t the 6#lymphocytes 5ere present *n the cort*cal re%*on o/ the /oll*cles per*/oll*cles and *n the s r/ace ep*thel* m.

CO#C"&SIO#S:)n some patholo%*cal cases the predom*nant cell lar pop lat*on o/ the clear center 5as /ormed by 6# lymphocytes