Product Catalogue

SHOWA DENKO K.K.

SHOWA DENKO K.K.

SHOWA DENKO K.K.

Skin Care

Slimming

Hair Care

Functional Chemicals Division

Showa Denko America, Inc.420 Lexington Avenue, Suite #2335A, New York, NY10170, U.S.A.

TEL: +1-212-370-0033http://www.showadenko.us/

Showa Denko Singapore(Pte.) Ltd.2 Shenton way, #15-03/04 SGX Centre 1, Singapore 068804

TEL: +65-6223-1889http://www.sds.com.sg/

Showa Denko (Shanghai) Co., Ltd. 18F, Wang Wang Building No.211 Shimen Yi Road, Shanghai 200041, China

TEL: +86-21-6217-5000http://sdsh-showadenko.com

Showa Denko Europe GmbHKonard-Zuse-Platz 3, 81829, Munich, Germany

TEL: +49-89-9399620http://www.showa-denko.com/

Korea Showa Chemicals Co. Sunhwa Tower 2F, 43, Sejong-daero 7-gil, Jung-gu, Seoul, Korea 100130

TEL: +82-2-3454-1831

Head Office: Showa Denko K.K.13-9, Shiba Daimon 1-Chome, Minato-ku, Tokyo 105-8518 Japan

TEL: +81-3-6402-5090, FAX: +81-3-5403-5730http://www.sdk.co.jp/english/

1610EN_EU

A4_8P_kannon 昭和電工 EUパンフ _1610 改訂

CategoryVitamin C Derivatives

Product Name

Vitamin EDerivative

Skin Care Lines Hair Care Products

Other Derivatives

INCI NAME

Quasi Drug (JP)

REACH (EU)

CFDA (CN)

Product Shape / Color

Package*

Usable Concentration / pH

Brightening

Hydration

Anti-Aging

Anti-Acne

Hair Care

Eye Care

Slimmig

Recommended Formula

CAS No.

Registration

Efficacy

3374-22-910318-18-0

Perm Solution,Perm Cream

○

pre-registered

DL-CysteineDL-Cysteine HCl

CYSTEINECYSTEINE HCL

Active

Powder / White

DL-Cysteine10 kg: CB

DL-Cysteine HCl20 kg: CB50 kg: FD

~7%

○

14032-62-3

Perm Solution,Perm Cream

in progress

SPIERA™

BUTYROLACTONETHIOL

Liquid / Colorless

1 kg: GB10 kg: PB

2~5%

○

299158-63-7

Serum,Emulsion, Cream

○○

TPNa™

SODIUM TOCOPHERYLPHOSPHATE

Active / Additive

Powder / White

1 kg: CB, AP 5 kg: FD, AP

0.2~2%

○

○

○

Serum,Emulsion, Cream

302345-18-2

APPRÉCIER™(APPS)

TRISODIUM ASCORBYLPALMITATE PHOSPHATE

○○

Powder / White

100 g:1 kg:

CB, APCB, AP

0.5~1%, pH7~8

○

○

○

APM

○○

Active / Additive

Powder / White

1 kg: CB 5 kg: FD

Serum, Gel, Cream

113170-55-1

1~8%, >pH7.0

MAGNESIUMASCORBYL PHOSPHATE

○

○

○

○

863922-14-9

Serum,Emulsion, Cream

HCAP™

HYDROXYCITRYLPALMITATE

in progress

Powder / White

1 kg: CB, AP

0.2~1%

○

○

Showa Denko’s Product Lineups

*) CB: Carton Box, FD: Fiber Drum, CB, AP: Aluminum Pouch in Carton Box, GB: Glass Bottle, PB: Plastic Bottle

CategoryVitamin C Derivatives

Product Name

Vitamin EDerivative

Skin Care Lines Hair Care Products

Other Derivatives

INCI NAME

Quasi Drug (JP)

REACH (EU)

CFDA (CN)

Product Shape / Color

Package*

Usable Concentration / pH

Brightening

Hydration

Anti-Aging

Anti-Acne

Hair Care

Eye Care

Slimmig

Recommended Formula

CAS No.

Registration

Efficacy

3374-22-910318-18-0

Perm Solution,Perm Cream

○

pre-registered

DL-CysteineDL-Cysteine HCl

CYSTEINECYSTEINE HCL

Active

Powder / White

DL-Cysteine10 kg: CB

DL-Cysteine HCl20 kg: CB50 kg: FD

~7%

○

14032-62-3

Perm Solution,Perm Cream

in progress

SPIERA™

BUTYROLACTONETHIOL

Liquid / Colorless

1 kg: GB10 kg: PB

2~5%

○

299158-63-7

Serum,Emulsion, Cream

○○

TPNa™

SODIUM TOCOPHERYLPHOSPHATE

Active / Additive

Powder / White

1 kg: CB, AP 5 kg: FD, AP

0.2~2%

○

○

○

Serum,Emulsion, Cream

302345-18-2

APPRÉCIER™(APPS)

TRISODIUM ASCORBYLPALMITATE PHOSPHATE

○○

Powder / White

100 g:1 kg:

CB, APCB, AP

0.5~1%, pH7~8

○

○

○

APM

○○

Active / Additive

Powder / White

1 kg: CB 5 kg: FD

Serum, Gel, Cream

113170-55-1

1~8%, >pH7.0

MAGNESIUMASCORBYL PHOSPHATE

○

○

○

○

863922-14-9

Serum,Emulsion, Cream

HCAP™

HYDROXYCITRYLPALMITATE

in progress

Powder / White

1 kg: CB, AP

0.2~1%

○

○

Skin

Car

e Pr

oduc

ts

Slim

ming

Rea

gent

s

Hair C

are

Prod

ucts

HCAP™

APPRÉCIER™ (APPS)

59 y/o Female

Base After

Slimming

Recommended Formula:Serum, Emulsion, Cream0.5~1%, pH7~8

APPS is a newly designed amphiphilic derivative of ascorbyl 2-phosphate (AP).

1% APPS

77 days

TGA Virgin Hair SPIERA™

・Moderate hydrophobicity ・High transdermal permeation　・Effective delivery of vitamin C

Human Test on Crow's Feet ( 　　　 )in vivo in vitro

in vitro

in vitro

Melanin Production ( 　　　 )Control 1% APPS

Anti-Wrinkle Brightening

Methods:□Female, aged 31-62 y/o, N=21□1% APPS lotion, 2 times/day for 1-3 months□Replica impression analysis of crow's feetResults:The application of APPS lotion exhibited effective improvement on replicas of crow's feet in eye area.

L-Cysteine DL-Cysteine DL-CysteineHCI

L-CysteineHCI

Cysteine solution; 5.4% Cysteine, pH9.4 with monoethanolamine.

Recommended Formula:Perm/relaxer solution, Cream2~5%

・No damage on hair・No chemical odor・No coloring retardation

SPIERA™ is perm and hair relaxer agent with mild acidity and superior performance compared with current alkaline processing treatments.

Chemical PropertyDL-Cysteine HCl / DL-Cysteine yields no segmentation in solution.

Recommended Formula:Perm Solution, Perm Cream~7%

・No recrystallization・High solubility in water (the left figure)・High perming performance・No harm on hair and hands

General cysteine-type permanent wave agents were difficult to use because of low solubility, segmentation and c loudy appearance in water. The improved DL-Cysteine agents have;

Fat Production Assay (　　 　)

Long Lasting, High Volume Perm

ReducingAgents

CurlingEfficiency

TGA Cysteine SPIERA™

pH pH9 pH6 pH9 pH6 pH5.6

86% 32% 62% 25% 67%

Curling Ability Comparison

Efficiency of Permanent Wave（%）

0DL-CysteineHCI

DL-Cysteine L-Cysteine L-CysteineHCI

20

40

60

80

Thioglycolicacid

■ Healthy/Normal hair■ Color-treated hair

① DL-Cysteine HCl② DL-Cysteine③ L-Cysteine HCl④ L-Cysteine

Methods:□TGA solution; 7% SPIERA™ solution; 2.5%□Repeated perming process 5 times.□Cuticle was observed by SEM.

Results:Hair cuticles remained smooth after repeated applications of SPIERA™, while treatment of TGA made hair cuticles rough and sparse.

Methods:□TGA / Cysteine solution; 7% SPIERA™ solution; 2.5%□Assessed by Kilby methodResults:The curling performance of SPIERA™ was exhibited powerful curling action in the natural pH condition of the hair.

Excellent TextureCuticle Comparisons after Treatment

Gentle on Beautician's HandsPerming Solution Residue Comparison

Methods:□Cysteine solution; 5.4% cysteine, 0.5% Thioglycolic acid (TGA), oxidant, and a chelating agent, pH9.4 with monoethanolamine

□TGA solution; 5.9% TGA, an emulsifying agent, and a chelating agent, pH9.4 with monoethanolamine

□Assessed by Kilby method.Results:The DL-Cysteine formula provided higher performance on perm, especially on the color-treated damaged hair.

Methods:□Applied cysteine solutions between fingers.□After washing with warm water and drying, powdery residue on the skin were observed.

Results:Existing perming agents give irritation and damages on hands of hair designers. DL-Cysteine series successfully reduce the amount of powdery residue and can be easily washed out it with water.

High Performance on PermCurling Ability Comparison

Methods:□Human adipocytes cultured with HCAP™ for 20 days□Oil droplets were detected by Oil Red O staining.Results:HCAP™ showed the significant efficacy on inhibition of lipid accumulation by inhibiting enzyme for fat production.

Anti-AgingElastin Production Assay (　　 　)Methods:□Human fibroblasts (FBs) were treated with H2O2 to establish aged-FBs.□Aged-FBs were treated with HCAP™ for 3 days.□Extracted elastin was detected.

Results:HCAP™ can effectively promote elastin production in aged-FBs.

Recommended Formula:Serum, Emulsion, Cream0.2~1%

・High transdermal permeability・High stability・Skin care efficacy on anti-age by mitochondria activation

Hydroxycitric acid (HCA) is popular slimming supplements by blocking fat synthesis. To effectively administrate in cosmetic formulation, HCAP™ is designed.

Applying Perming Reagents After Rinse and Dry

DL-Cysteine HCl & DL-Cysteine

×600

×5,000

1.2

Lipid Formation

Control0

HCAP™（μM）

1.0

0.8

0.6

0.4

0.2

1.210 50

（μM）

Elastin/ Cell

HCAP™Aged FBs

ControlNormal FBs

1

1.5

0.5

00 0 0.01 0.1

2-Palmitoyl Hydroxycitric Acid (HCAP™) 2-Mercapto-4-Butanolide (SPIERA™)

Methods:□1% APPS in PBS on human skin model □N=3

Results:APPS application significantly reduces melanin production in reconstructed human skin model.

Trisodium Ascorbyl 6-Palmitate 2-Phosphate (APPS)

SPIERA™

Product MappingOur product lineups can answer your challenge!

This catalog only explains the extracts of our product properties. If you have an interest in any of our products, we can provide full-written files of “Technical Information” for efficacies and formulation tips and also product samples. Please feel free to contact us !

HCAP™Control Fat Accumulation

HCAP™ and Hi-Carnitine play different roles in slimming support with skincare.

HCAP™ ”Inhibits Fat Production and Reduces Fat” 　　

HCAP™

差し替え

Anti-Acne

Whitening

Anti-AgingAnti-Wrinkles

Hair Care

SlimmingMoisturizing

APPRÉCIER™

DL-CysteineDL-Cysteine HClSPIERA™

TPNa™

HCAP™

Eye Care

APM

TPNa™

Sodium 　-α-Tocopheryl Phosphate (TPNa™)dl

in vivoHuman Test on Acne Patients ( 　　　) in vitroCeramide Production ( 　　　 )

Methods:□Human e p i d e rma l keratinocytes treated with TPNa™ for 24 hrs□Ceramide extracted by Bligh & Dyer method□Ceramide detected by labeled fluorescence after acid hydrolysis

Results:TPNa™ application significantly increases ceramide production and promotes skin barrier formation.

Recommended Formula:Serum, Emulsion, Cream0.2~2%

Vitamin E derivative, TPNa™, is designed as water-soluble powder which is quite stable but is readily converted to the active α-tocopherol in the skin.・Water-soluble powder・Easy for formulation・High anti-oxidant effects

Anti-Acne Hydration

109

7

3

1

Ceramide (μg/mg protein)

8

654

2

00 10

TPNa™ (μM)50

Methods:□Acne Patients, aged 24-36 y/o, N=7□2% TPNa™ cosmetic water, 2 times/day for 4 weeksResults:Acne spots and redness from inflammation was improved after 1 month-treatment of 2% TPNa™ lotion.

4 weeksBase

α-Tocopherol TPNa™

+ nNa+ + (2-n)H+

APM

Brightening Anti-Acne

Methods:□Acne Patients, aged 11-50 y/o, N=40□5-7% AP lotion and orally minocycline (50 mg/day)□Analyzed by Dr. Lookingbill’s methodResults:Acne spots and redness from inflammation was improved with 5% AP lotion. Efficacy rate of 5-7% AP lotion users was 93% among 40 patients.

Recommended Formula :

Melanin Production ( 　　　 )in vitro Human Test on Acne Patients ( 　　　)in vivo

Serum, Gel, Cream1~8%, >pH7.0

APM is a stable and active provitamin C.

・Stable against oxidation・Easy for formulation・High skin bio-availability of vitamin C

Control 6% APMMethods:□6% APM in phosphate buffered saline (PBS) on human skin model for 14 days□N=3

Results:APM application reduces melanin production in reconstructed human skin model.

Ascorbyl 2-Phosphate Magnesium Salt (APM)

Base 3 months