A. Wayne Orr, Ph.D. - University of...

Curriculum Vitae February 15, 2016

A. Wayne Orr, Ph.D.

Louisiana State University Health Sciences Center - Shreveport Department of Pathology

Biomedical Research Institute, Rm 6-21 1501 Kings Highway

Shreveport, LA 71130 PERSONAL DATA Address 206 Colonel Burt Dr. Benton, LA 71006 Phone Office: (318) 675-5462 Lab: (318) 675-5463

Cell: (318) 564-8631 E-mail [email protected] Date and Place of Birth November 1, 1975, Jonesboro, AR EDUCATION 1990-1994 High school Jonesboro High School, Jonesboro, AR 1994-1998 B.A. Biology Hendrix College, Conway, AR 1998-2002 Ph.D. Pathology University of Alabama at Birmingham, Birmingham, AL (Joanne Murphy-Ullrich, Ph.D.) 2002-2007 Post-doc University of Virginia, Charlottesville, VA (Martin A. Schwartz, Ph.D.) APPOINTMENTS/EMPLOYMENT 2013- Associate Professor with tenure, Departments of Pathology and Cell Biology and

Anatomy, LSU Health Sciences Center-Shreveport 2008- Assistant Professor, Department of Cell Biology and Anatomy, LSU Health Sciences

Center-Shreveport. 2007- Assistant Professor, Department of Pathology, LSU Health Sciences Center-Shreveport 2007 Assistant Professor of Research, Microbiology Department, University of Virginia 2006-2007 Post-doctoral Fellow, Cardiovascular Training Grant, University of Virginia 2003-2006 American Heart Association Post-doctoral Fellow, University of Virginia Post-doctoral Fellow, Cardiovascular Training Grant (declined) 1999-2002 Pre-doctoral Fellow, Cardiovascular Training Grant, University of Alabama-Birmingham PROFESSIONAL AFFILIATIONS 2001- American Society for Matrix Biology (ASMB) 2006- North American Vascular Biology Organization (NAVBO) 2007- American Heart Association (AHA) 2010- American Diabetes Association (ADA) 2013- American Society for Cell Biology (ASCB)

AWARDS/HONORS 2001, 2002 UAB Graduate School Outstanding Student Award in Pathology 2007 Robert M. Berne Trainee Achievement Award 2007 American Heart Association Scientist Development Grant

A. Wayne Orr

2010 American Diabetes Association Junior Faculty Award 2011 Junior Investigator Award Honorable Mention, NAVBO Workshops in Vascular

Biology 2011 RESEARCH SUPPORT

Active/Pending/Completed: Active

Project Number/PI/Role 15GRNT25560056, AW Orr, PI

Source: American Heart Association, Grant-In-Aid

Title of Project (and/or Subproject): Integrin-specific signaling in endothelial cell activation.

Dates of Approved/Proposed Project: 07/01/15-06/30/17

The goals of this project are to determine the proximal mechanisms regulating integrin-specific NF-B activation and to characterize how specific provisional matrix-binding integrins contribute to endothelial cell activation in vivo.

Annual Direct Costs (Percent Effort) $75,000 (10%)

Active/Pending/Completed: Active

Project Number/PI/Role HL113303, C. Kevil (PI), Collaborator

Source: National Heart Lung and Blood Institute, R01

Title of Project (and/or Subproject): Hydrogen sulfide in ischemic vascular remodeling



Active/Pending/Completed: Pending (10%)

Project Number/PI/Role R01 HL133497, A.W. Orr, PI


Title of Project (and/or Subproject): Nck adaptor proteins in atherogenic endothelial activation.

The goals of this project are to characterize the PECAM-1/Nck complex formation in shear and oxidant stress, characterize the composition and function of Nck-based signaling complexes during endothelial cell activation, and determine whether endothelial Nck signaling affects atherogenic endothelial activation in vivo.

Dates of Approved/Proposed Project: 7/01/16- 6/31/20 (20%)

Active/Pending/Completed: Pending R01 Renewal (42%)

Project Number/PI/Role HL098435, AW Orr, PI


Title of Project (and/or Subproject): Matrix-specific signaling in endothelial cell dysfunction.

Dates of Approved/Proposed Project: 07/01/15- 06/30/19

This goal of this project is to define the role of endothelial integrin activation in fibronectin matrix deposition both in cell culture and models of early atherogenesis in vivo, to utilize novel genetic and biochemical techniques to define the differential proinflammatory signaling mechanisms activated by

51 and v3, and to employ recently developed inducible endothelial cell-specific knockout models to further define the role of each integrin in endothelial activation in vivo.


A. Wayne Orr

Active/Pending/Completed: Pending

Project Number/PI/Role A.W. Orr, Core Leader (Kevil PI)

Source: National Institute of General Medical Sciences, COBRE

Title of Project (and/or Subproject): Center for Redox Biology and Cardiovascular Disease

The overall objectives of the COBRE Center for Redox Biology and Cardiovascular Disease are to establish a nationally recognized advanced research and training program in redox biology regulation of cardiovascular disease and to facilitate the development of junior faculty research programs to achieve major independent research funding.


Active/Pending/Completed: Pending

Project Number/PI/Role M. Woolard, PI, Collaborator


Title of Project (and/or Subproject): Lipin-1 and atherosclerosis

The goal of this project is to test the hypothesis that lipin-1 enzymatically generated diglyceride activates signaling cascades responsible for modified LDL elicited pro-inflammatory cytokine production in foam cells thereby promoting atherosclerosis.


Active/Pending/Completed: In preparation

Project Number/PI/Role A.W. Orr, PI

Source: American Diabetes Association – Innovative Basic Science Award

Title of Project (and/or Subproject): 51 integrin activation in accelerated diabetic atherosclerosis

The goals of this project are to characterize the role of oxidant stress in 51 integrin activation, to determine the role of endothelial integrin activation in early diabetic atherogenesis, and to examine the

specific role of endothelial cell 51 integrins in accelerated diabetic atherosclerosis.

Dates of Approved/Proposed Project:

Active/Pending/Completed: In preparation

Project Number/PI/Role A.W. Orr, PI


Title of Project (and/or Subproject): EphA2 signaling in atherogenic vascular remodeling

The goal of this project is to characterize the molecular mechanisms by which EphA2 signaling contributes to endothelial cell activation, to assess how EphA2 expression and activation affect smooth muscle function, and to evaluate the effect of EphA2 inhibition on atherosclerotic fibroproliferative remodeling.

Dates of Approved/Proposed Project:

A. Wayne Orr

Active/Pending/Completed: Completed

Project Number/PI/Role 14PRE18660003, A. Yurdagul Jr. (Fellowship), Mentor

Source: American Heart Association Pre-doctoral Fellowship

Title of Project (and/or Subproject): Integrin signaling in oxidized LDL-induced inflammation



Project Number/PI/Role 13GRNT17050093, A.W. Orr, PI

Source: American Heart Association, Grant-In-Aid

Title of Project (and/or Subproject): EphA/ephrinA interactions in atherosclerotic inflammation



Project Number/PI/Role HL098435, AW Orr, PI


Title of Project (and/or Subproject): Matrix-specific signaling in endothelial cell dysfunction.



Project Number/PI/Role LEQSF (2008-13)-FG-20, A. Yurdagul Jr. (Fellowship), Mentor

Source: Superior Toxicology Fellowship from the Louisiana Board of Regents Grant

Title of Project (and/or Subproject): Matrix in oxidized LDL-induced endothelial cell activation.



Project Number/PI/Role S. Funk (Fellowship), Mentor

Source: Malcolm Feist Predoctoral Cardiovascular Fellowship

Title of Project (and/or Subproject): EphA2 signaling in atherogenic inflammation.



Project Number/PI/Role 1-10-JF-39, AW Orr, PI

Source: American Diabetes Association – Junior Faculty Award

Title of Project (and/or Subproject): Matrix signaling in hyperglycemia-induced endothelial cell dysfunction.


A. Wayne Orr

PUBLICATIONS

Journals published in: J. Biol. Chem. (5), Arterioscler. Thromb. Vasc. Biol. (4), Circ. Res. (3), JCB (3), Mol. Biol. Cell (3), Am. J. Physiol. Cell Physiol. (1), Dev. Cell (1), Front. Biosci. (1), Int. J. Cell Biol. (1), Int. J. Vasc. Med. (1), J. Cell Sci. (1), J. Clin. Invest. (1), J. Theor. Biol. (1), J. Vasc. Res (1), Kidney International (1), Pharmacol. Res. (1), PLoS One (1), Toxicol. Sci. (1), Review Articles (7)

1. Orr A.W.*, Goicoechea S.*, Pallero M.A., Eggleton P., and J.E. Murphy-Ullrich. (2000)

Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. J. Biol. Chem. 275: 36358-36368. (* co-first authors)

2. Orr A.W., Pallero M.A., and J.E. Murphy-Ullrich. (2002) Thrombospondin stimulates focal

adhesion disassembly through Gi- and PI 3-kinase-dependent ERK activation. J. Biol. Chem. 277: 20453-20460.

* Selected by Faculty of 1000


Project Number/PI/Role 0735308N, AW Orr, PI

Source: American Heart Association – Scientist Development Grant

Title of Project (and/or Subproject): Matrix-specific PKA and PAK signaling regulate flow-induced endothelial cell dysfunction.



Project Number/PI/Role AW Orr, PI

Source: LSUHSC-S/BRF Grant-In-Aid

Title of Project (and/or Subproject): Ephrin signaling in endothelial cell dysfunction and atherosclerosis.




Project Number/PI/Role AW Orr, Post-doctoral fellowship

Source: American Heart Association – Mid-Atlantic Affiliate

Title of Project (and/or Subproject): The integrin pathway in the differential endothelial cell response to laminar and disturbed flow.



Project Number/PI/Role AW Orr, Post-doctoral fellowship

Source: American Heart Association – Mid-Atlantic Affiliate

Title of Project (and/or Subproject): Integrin signaling in the endothelial response to shear stress.


A. Wayne Orr

3. Orr A.W.*, Pedraza C.E.*, Pallero M.A., Elzie, C.A., Goicoechea S., Strickland D.K., and J.E. Murphy-Ullrich. (2003) Low-density-lipoprotein-receptor-related protein is a calreticulin co-receptor that signals focal adhesion disassembly. J. Cell Biol. 161: 1179-1189. (* co-first authors).

4. Orr A.W., Elzie C.A., Kucik D.F., and J.E. Murphy-Ullrich. (2003) Thrombospondin signaling

through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration. J. Cell Sci. 116: 2917-2927.

5. Orr A.W.*, Kevil C.G.*, Langston W., Mickett K., Murphy-Ullrich J.E., Patel R.P., Kucik D.F., and

D. Bullard. (2004) ICAM-1 regulates endothelial cell motility through an NO-dependent pathway. J. Biol. Chem. 279: 19230-19238. (* co-first authors)

6. Orr A.W., Pallero M.A., Xiong W.-C., and J.E. Murphy-Ullrich. (2004) Thrombospondin induces

RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly. J. Biol. Chem. 279: 48983-48992.

7. Orr A.W. and J.E. Murphy-Ullrich. (2004) Regulation of endothelial cell function by FAK and

Pyk2. Front. Biosci. 9: 1254-1266. 8. Orr A.W.*, Katsumi A.*, Tzima E.*, and M.A. Schwartz. (2004) Integrins in

mechanotransduction. J. Biol. Chem. 279: 12001-12004. (* co-first authors) 9. Civelekoglu-Sholey G., Orr A.W., Novak I., Meister J.-J., Schwartz M.A., and A. Mogilner.

(2005) Model of endothelial cell signaling and cytoskeletal reorganization in response to force. J. Theor. Biol. 232: 569-585.

10. Orr A.W., Sanders J.M., Bevard M., Coleman E.J., Saremboch I.J., and M.A. Schwartz. (2005)

The subendothelial extracellular matrix modulates NF-B activation by flow: a potential role in atherosclerosis. J. Cell Biol. 169: 191-202.

Commentaries: Editor’s Choice. Signaling to the Substrate. Science STKE 2005, tw150

(2005). Research Highlights. The Matrix Reloaded. Nat. Rev. Mol. Cell. Biol. 6: 434, 2005.

R.S. Tuma. ECM controls flow-induced NFB. JCB 169: 14, 2005. 11. Bolick D.T., Orr A.W., Whetzel A., Srinivasan S., Hatley M.E., Schwartz M.A., and C.C. Hedrick.

(2005) 12/15 Lipoxygenase Regulates ICAM-1 Expression and Monocyte Adhesion to Endothelium Through Activation of RhoA and PKCα. Arterioscler. Thromb. Vasc. Biol. 25, 2301-2307.

12. Orr A.W., Ginsberg M.H., Shattil S.J., Deckmyn H., and M.A. Schwartz. (2006) Matrix-specific

suppression of integrin activation in shear stress signaling. Mol. Biol. Cell. 17, 4686-4697. * Selected by Faculty of 1000

13. Orr A.W., Helmke B., Blackman B.R., and M.A. Schwartz. (2006) Mechanisms of

mechanotransduction. Dev. Cell. 10: 11-20. 14. Orr A.W., Stockton R.A., Simmers M., Sanders J.M., Blackman B.R., Sarembock I.J., and M.A.

Schwartz. (2007) Matrix-specific PAK signaling regulates vascular permeability in atherogenesis. J. Cell Biol. 176: 719-727.

A. Wayne Orr

Commentaries: R. Williams. Vascular Permeability: The Flow Factor. JCB 176: 548, 2007.

** Selected by Faculty of 1000 15. Orr A.W., Hahn C., Blackman B.R., and M.A. Schwartz. (2008) p21 activated kinase regulates

oxidant-dependent NF-B activation by flow. Circ. Res. 103: 671-679. Commentaries: L.S. Terada. What Underlies Endothelial Shear Signaling: The Matrix,

Of Course. Circ. Res. 103: 562-564, 2008. Cover Image

16. Orr A.W., Lee M.Y., Lemmon J.A., Yurdagul A. Jr., Gomez M.F., Schoppee-Bortz P.D., and

B.R. Wamhoff. (2009) Molecular mechanisms of collagen isotype-specific modulation of smooth muscle cell phenotype. Arterioscler. Thromb. Vasc. Biol. 29: 225-231.

17. Hahn C., Orr A.W., Sanders J., Jhaveri K., and M.A. Schwartz. (2009) The subendothelial

matrix modulates JNK activation by flow. Circ. Res. 104: 995-1003. Commentaries: J.Y. Shyy. Extracellular matrix differentiating good flow versus bad flow.

Circ. Res. 104: 931 18. Petzold T., Orr A.W., Hahn C., Jhaveri K., Parsons J.T., and M.A. Schwartz. (2009) FAK

signaling regulates NF-B activation by flow. Am. J. Physiol. Cell Physiol. 297: C814-22. Commentaries: Chien S., Chiu J.J., and Y.S. Li. (2009) Focal adhesion kinase

phosphorylation in flow-activation of endothelial NF-B. Am. J. Physiol. Cell Physiol. 297: C800-1.

19. Orr A.W., Hastings N.E., Blackman B.R., and B.R. Wamhoff. (2010) Complex regulation and

function of the inflammatory smooth muscle cell phenotype in atherosclerosis. J. Vasc. Res. 47: 168-180.

20. Funk S.D., Yurdagul Jr. A., Green J.M., Jhaveri K., Schwartz M.A., and A.W. Orr. (2010)

Matrix-specific protein kinase A signaling regulates p21 activated kinase activation by flow in endothelial cells. Circ. Res. 106: 1394- 1403.

21. Chen S., Wassenhove-McCarthy D., Yamaguchi Y., Holzman L., van Kuppevelt T., Orr A.W.,

Funk S.D., Woods A., and K. McCarthy. (2010) Podocytes require the engagement of cell surface heparan sulfate proteoglycans for adhesion to extracellular matrices. Kidney Int. 78: 1088-1099.

22. Jiang B., Khandelwal A.R., Rogers L.K., Shi W., Orr A.W., and T.R. Dugas. (2010)

Antiretrovirals induce endothelial cell dysfunction via an oxidant-dependent pathway and promote neointimal hyperplasia in C57Bl/6 mice. Toxicol. Sci. 117: 524-536.

23. Lee B., Clarke D., Al Ahmad A., Parham C., Auckland L., Dogruel M., Fidanboylu M., Orr A.W.,

Fertala A., Thomas S., Bayless K., Ogunshola O., and G. Bix. (2011) Perlecan domain V protects, repairs, and restores ischemic brain stroke injury and motor function. J. Clin. Invest. 121: 3005-3023.

24. Hahn C., Wang C., Orr A.W., Coon B.G., and M.A. Schwartz. (2011) JNK2 promotes

endothelial cell alignment under flow. PLOS One. 6: e24338.doi:10.137/journal/pone.0024338.

25. Chen J., Alexander J.S., and A.W. Orr. (2012) Integrins and their extracellular matrix ligands in lymphangiogenesis and lymph node metastasis. Int. J. Cell Biol. 2012: 853703. doi:10.1155/2012/853703.

A. Wayne Orr

26. Funk S.D., Yurdagul Jr. A., and A.W. Orr. (2012) Hyperglycemia and endothelial dysfunction in

atherosclerosis: lessons from type 1 diabetes. Int. J. Vasc. Med. 2012: 569654. doi:10.1155/2012/569654.

27. Funk S.D., Yurdagul Jr. A., Albert P., Traylor J., Jin L., Chen J., and A.W. Orr. (2012) EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 32: 686-695.

28. Pitre A., Davis N., Paul M., Orr A.W., and O. Skalli. (2012) Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A. Mol. Biol. Cell. 23: 1243-1253.

29. Scott D.W., Chen J., Chacko B.K., Azadi P., Novak J., Karbarowski J.H., Orr A.W., and R.P. Patel. (2012) Endothelial expressed high-mannose N-glycans are required for efficient monocyte adhesion under flow. Arterioscler. Thromb. Vasc. Biol. 32: e51-9.

30. Funk S.D. and A.W. Orr. (2013) Ephs and ephrins resurface in inflammation, immunity, and atherosclerosis. Pharmacol. Res. 67: 42-52.

31. Yurdagul Jr. A., Chen J., Funk S.D., Albert P., Kevil C.G., and A.W. Orr. (2013) Altered nitric

oxide production mediates matrix-specific PAK2 and NF-B activation by flow. Mol. Biol. Cell. 24: 398-408.

Highlights from MBoC Selection ** Selected by Faculty of 1000

32. Ellison S., Gabunia K., Kelemen S.E., England R.N., Scalia R., Richards J.M., Orr A.W., Traylor J.G. Jr., Rogers T., Cornwell W., Berglund L.M., Goncalves I., Gomez M.F., and M.V. Autieri. (2013) Attenuation of experimental atherosclerosis by interleukin IL-19. Arterioscler. Thromb. Vasc. Biol. 33: 2316- 2324.

33. Green J., Yurdagul Jr. A., McInnis M.C., Albert P., and A.W. Orr. (2014) Flow patterns regulate hyperglycemia-induced subendothelial matrix remodeling during early atherogenesis. Atherosclerosis. 232: 277-284.

34. Yurdagul Jr. A., Kleinedler J.J., McInnis M.C., Orr A.W.*, and T.R. Dugas. (2014) Resveratrol promotes endothelial cell wound healing under laminar shear stress through an estrogen receptor α dependent pathway. Am. J. Physiol. Heart Circ. 306: H797-806. (* corresponding author)

35. Yurdagul Jr. A., Green J., Albert P, McInnis M.C., Mazar A.P., and A.W. Orr. (2014) 51 integrin signaling mediates oxidized LDL-induced inflammation and early atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 34: 1362-1373.

36. Kotla S., Singh N.K., Traylor J.G., Orr A.W., and G.N. Rao. (2014) ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-Hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation. Free Rad. Biol. Med. 76: 147- 162.

37. Chen J., Leskov I., Yurdagul A. Jr., Thiel B., Kevil C.G., Stokes K.Y., and A.W. Orr. (2015)

Recruitment of the adaptor protein Nck to PECAM-1 couples oxidant stress to canonical NF-B signaling and inflammation. Sci. Signal. 8: ra20.

38. Becker F., Potepalov S., Shehzahdi R., Bernas M., Witte M., Abreo F., Traylor J., Orr A.W.,

Tsunoda I., and J.S. Alexander. (2015) Downregulation of FoxC2 increased susceptibility to

A. Wayne Orr

experimental colitis: influence of lymphatic drainage function? Inflamm. Bowel Dis., 21: 1282-1296.

39. Singh N.K., Kotla S., Dyukova E., Traylor J.G., Orr A.W., Chernoff J., Marion T., and G.N. Rao. (2015) Disruption of p21-activated kinase 1 (PAK1) gene diminishes atherosclerosis in Apolipoprotein E-deficient mice. Nat. Commun. 6: 7450.

40. Holloway P., Durrenberger P., Cooper D., Orr A.W., Perretti M., Getting S., and F. Gavins. (2015) Both MC1 and MC3 receptors provide protection from cerebral ischemia reperfusion induced neutrophil recruitment. Arterioscler. Thromb. Vasc. Biol., 35: 1936-1944.

41. Chen J.*, Green J.*, Yurdagul A. Jr., Albert P., McInnis, M.C., and A.W. Orr. (2015) v3

integrins mediate flow-induced NF-B activation, proinflammatory gene expression, and early atherogenic inflammation. Am. J. Pathol., 185: 2575-2589. * co-first authors.

42. Navratil A.R., Vozenilek A.E., Cardelli J.A., Green J.M., Thomas M.J., Sorci-Thomas M.G., Orr

A.W., and M. Woolard. (2015) Lipin-1 contributes to modified low-density lipoprotein-elicited macrophage pro-inflammatory responses. Atherosclerosis, 242: 424-432.

43. Becker F., Kurmaeva E., Gavins F., Stevenson E.V., Navratil A.R., Jin L., Tsunoda I., Orr A.W., Alexander J.S., and D. Ostanin. (2016) Ablation of CCR2 in acute and chronic colitis: two potentially independent roles for monocytes/macrophages in inflammation versus lymphangiogenesis. In press at Inflamm. Bowel Dis.

44. Yurdagul Jr. A. and A.W. Orr. (2016) Blood brothers: hemodynamics and cell-matrix interactions in endothelial function. In press at Antioxid. Red. Sig.

45. Yurdagul Jr. A., Finney A.C., Woolard M.D., and A.W. Orr. (2016) The Arterial Microenvironment: The Where and Why of Atherosclerosis. In press at Biochem J.

46. Yurdagul Jr. A., Sulzmaier F., Chen X.L., Pattillo C.B., Schlaepfer D.D., and A.W. Orr. (2016)

Focal adhesion kinase activates RSK to drive NF-B activation and endothelial proinflammatory gene expression by oxidized LDL. In press at J. Cell Sci.

Under revision/Submitted/In Preparation

47. Sugar T., Wassenhove-McCarthy D.J., Orr A.W., Green J., Esko J.D., van Kuppevelt T.H., and

K.J. McCarthy. N-sulfation of heparan sulfate glycosaminoglycans is a key, critical component of podocyte cell-matrix interactions. (in revision at Am J Physiol Renal Physiol)

48. Russel-Puleri S., Ebong E., Orr A.W., and J.M. Tarbell. Fluid shear stress induces upregulation of COX-2 and PGI2 release in endothelial cells via a pathway involving PECAM-1, PI3K, FAK, and p38. (in revision at Am J Physiol Heart Circ)

49. Finney A.C., Green J., Langford E., and A.W. Orr. Integrin signaling in atherosclerosis. Invited review for Cell. Mol. Life Sci. (in preparation)

50. Finney A.C.*, Funk S.D.*, Green J.*, Yurdagul A. Jr., Chen J., Woolard M.D., Kevil C.G., and A.W. Orr. Deletion of the guidance molecule EphA2 reduces inflammation during atherosclerotic plaque formation. (In preparation for ATVB)

A. Wayne Orr

51. Yurdagul Jr. A., Green J., Foxworth B.D., and A.W. Orr. Endothelial 5 integrins regulate oxLDL-induced fibronectin deposition, proinflammatory gene expression, and early atherosclerosis. (In preparation for Cardiovascular Research)

52. Funk S.D, Finney A.C., Yurdagul A. Jr., Mathews S.U., Albert P., and A.W. Orr. EphA2 receptor

activation promotes FAK-dependent NFAT1 signaling to drive inflammatory gene expression. (In preparation)

Published abstracts at national meetings

# denotes seminar 53. #Orr A.W., Goicoechea S., Pallero M.A., Eggleton P., and J.E. Murphy-Ullrich. (2000)

Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. Thrombospondin International Meeting 2000, Madison, WI. June 2000.

54. Orr A.W., Goicoechea S., Pallero M.A., Eggleton P., and J.E. Murphy-Ullrich. (2000)

Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. American Society for Cell Biology Annual Meeting. San Francisco, CA. December 2000.

55. Orr A.W., Pallero M.A., Kucik D.F. and J.E. Murphy-Ullrich. (2002) Thrombospondin stimulates

focal adhesion disassembly through Gi- and PI 3-kinase-dependent ERK activation. Keystone Symposium on Biological Responses to the Extracellular Matrix. Banff, Alberta. February 2002.

56. Orr A.W., Tzima E., and M.A. Schwartz. (2003) Differential integrin signaling in response to

endothelial shear stress. 4th Annual Colloquium on Cell Adhesion and Biomechanics. University of Virginia. Charlottesville, VA. September 2003.

57. Bolick D.T., Orr A.W., Whetzel A., Srinivasan S., Hatley M.E., Schwartz M.A., and C.C. Hedrick.

(2005) 12/15 Lipoxygenase Regulates ICAM-1 Expression and Monocyte Adhesion to Endothelium Through Activation of RhoA and PKCα. 6th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology. Washington, D.C. April 2005.

58. Diao L., Orr A.W., Srinivasan S., and C.C. Hedrick. (2005) Sphingosine-1-phosphate prevents

monocyte:endothelium interactions in type 2 diabetic db/db mice. American Heart Association Scientific Sessions. Dallas, TX. November 2005.

59. #Orr A.W., Stockton R.A., Simmers M., Sanders J.M., Blackman B.R., Sarembock I.J., and M.A.

Schwartz. (2007) Matrix-specific PAK signaling regulates vascular permeability in atherogenesis. Experimental Biology 2007. Washington, D.C., April 2007.

60. Hahn C., Orr A.W., Sanders J.M., Sarembock I.J., and M.A. Schwartz. (2007) Matrix-specific

JNK activation by flow. Experimental Biology 2007. Washington, D.C., April 2007. 61. Orr A.W., Lemmon J., Lee M., Schoppee-Bortz P.D., and B.R. Wamhoff. (2008) Molecular

mechanisms of collagen subtype-specific induction of smooth muscle phenotypic modulation. Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2008. Atlanta, GA, April 2008.

62. Simmers M.B., Orr A.W., Schwartz M.A., and B.R. Blackman. (2008) -catenin regulates endothelial permeability and polarity in response to fluid shear stress. Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2008. Atlanta, GA, April 2008.

A. Wayne Orr

63. Hastings N.E., Lee M.Y., Orr A.W., Wamhoff B.R., and B.R. Blackman. (2008) A hemodynamic

role for endothelial-derived Interleukin-8 to limit an inflammatory smooth muscle cell phenotype in atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2008. Atlanta, GA, April 2008.

64. Orr A.W., Hahn C., Blackman B.R., and M.A. Schwartz. (2008) PAK regulates oxidant-

dependent NF-B activation by flow. Signaling by Adhesion Receptors Gordon Conference, Mount Holyoke College, MA, June 2008.

65. #Orr A.W., Hahn C., Blackman B.R., and M.A. Schwartz. (2008) PAK regulates oxidant-

dependent NF-B activation by flow. Workshop: Biology of Signaling in the Cardiovascular System, Hyannis, MA, September 2008.

66. Funk S., Yurdagul Jr. A., Javeri K., Schwartz M.A., and A.W. Orr. (2009) Matrix-specific protein

kinase A activation by flow inhibits p21 activated kinase-dependent endothelial cell dysfunction. Arterioscler. Thromb. Vasc. Biol. Conference 2009. Washington, D.C., April 2009.

67. Funk S., Albert P., Yurdagul Jr. A., and A.W. Orr. (2009) EphA2 in the endothelial inflammatory

response: a potential regulator of atherosclerosis. Arterioscler. Thromb. Vasc. Biol. Conference 2009. Washington, D.C., April 2009.

68. Simmers M.B., Orr A.W., and B.R. Blackman. (2009) -catenin-dependent ERK1/2 activation regulates shear stress-induced permeability. Arterioscler. Thromb. Vasc. Biol. Conference 2009. Washington, D.C., April 2009.

69. Khandelwal A.R., Yurdagul Jr. A., Orr A.W., and T.R. Dugas (2009). Resveratrol modulates

estrogen receptor-Rho GTPase axis to reduce restenosis in a mouse carotid artery injury model. South Central Chapter Society of Toxicology Fall Meeting, Shreveport, LA, October 2009.

70. Khandelwal A.R., Yurdagul Jr. A., Orr A.W., and T.R. Dugas (2009). Resveratrol modulates

estrogen receptor-Rho GTPase axis to reduce restenosis in a mouse carotid artery injury model. American Heart Association Scientific Sessions 2009. Orlando, FL, November 2009.

71. Funk S., Albert P., Yurdagul Jr. A., and A.W. Orr. (2010) EphA2 in the endothelial inflammatory

response: a potential regulator of atherosclerosis. Arterioscler. Thromb. Vasc. Biol. Conference 2010. San Francisco, CA, April 2010.

72. Yurdagul Jr. A., Funk S.D., Albert P., and A.W. Orr. (2010) PKA-dependent PAK2 serine 20

phosphorylation regulates the endothelial cell inflammatory response to flow. Arterioscler. Thromb. Vasc. Biol. Conference 2010. San Francisco, CA, April 2010.

73. Funk S., Yurdagul Jr. A., Albert P., Traylor J., Jin L., Chen J., and A.W. Orr. (2010) EphA2 in

the endothelial inflammatory response: a potential regulator of atherosclerosis. Eph/ephrins and Cancer Meeting 2010. Winston-Salem, SC, June 2010.


the endothelial inflammatory response: a potential regulator of atherosclerosis. Endothelial Cell Phenotypes in Health & Disease Gordon Conference. Biddeford, ME, August 2010.

75. #Kleinedler J.J., Foley J.F., Hebert V., Orr A.W., Yurdagul A., and T.R. Dugas. (2010)

Polyphenol-eluting stent coating, a novel approach for the prevention of restenosis with reduced

A. Wayne Orr

side effects. South Central Chapter Society of Toxicology Fall Meeting, Starkville, MS, October 2010.

76. Simmers M.B., Pryor A., Orr A.W., and B.R. Blackman. (2011) Hemodynamic regulation of

shear stress-induced permeability is PAK and -catenin dependent. Arterioscler. Thromb. Vasc. Biol. Conference 2011. Chicago, IL, April 2011.

77. #Kleinedler J.J., Foley J.F., Hebert V., Orchard E.A., Orr A.W., Yurdagul A., and T.R. Dugas.

(2011) Red wine polyphenol-eluting stent reduces neointimal hyperplasia and promotes reendothelialization in a rat model of stenting angioplasty. Arterioscler. Thromb. Vasc. Biol. Conference 2011. Chicago, IL, April 2011.

78. Yurdagul Jr. A., Funk S.D., Albert P., and #A.W. Orr. (2011) Basement membrane proteins

enhance flow-induced nitric oxide production to limit NF-B activation. Arterioscler. Thromb. Vasc. Biol. Conference 2011. Chicago, IL, April 2011.


the endothelial inflammatory response: a potential regulator of atherosclerosis. Vasculata 2011. Atlanta, GA, July 2011.

80. Yurdagul Jr. A., Funk S.D., Albert P., and A.W. Orr. (2011) Basement membrane proteins

enhance flow-induced nitric oxide production to limit NF-B activation. Vasculata 2011. Atlanta, GA, July 2011.

81. Chen J.*, Yurdagul Jr. A.*, and A.W. Orr. (2011) Inhibitors of transitional matrix binding integrins

blunt early atherogenesis. Vasculata 2011. Atlanta, GA, July 2011. (* co-first authors)

82. Funk S., Yurdagul Jr. A., Albert P., Traylor J., Jin L., Chen J., and A.W. Orr. (2011) EphA2 in the endothelial inflammatory response: a potential regulator of atherosclerosis. NAVBO Workshops in Vascular Biology 2011. Hyannis, MA, October 2011.

83. Yurdagul Jr. A., Funk S.D., Albert P., Mazar A., Kevil C.G., and A.W. Orr. (2011) Basement

membrane proteins enhance flow-induced nitric oxide production to limit NF-B activation. NAVBO Workshops in Vascular Biology 2011. Hyannis, MA, October 2011.

84. Yurdagul Jr. A., Albert P., and A.W. Orr. (2011) Matrix composition tunes the endothelial cell response to oxidized LDL between apoptosis and inflammation. NAVBO Workshops in Vascular Biology 2011. Hyannis, MA, October 2011.

85. Chen J.* and A.W. Orr. (2011) Shear stress-induced proinflammatory responses on transitional

matrices requires αv integrins but not α5β1. NAVBO Workshops in Vascular Biology 2011. Hyannis, MA, October 2011. * Travel Award Recipient.

86. Green J., Yurdagul Jr. A., Mazar A.P., and A.W. Orr. (2012) Hyperglycemia induces fibronectin deposition at sites of disturbed flow to drive early atherogenesis. Keystone Symposia: Complications of Diabetes: Mechanisms of Injury and Failure of Repair. Boston, MA, March 2012.

87. Funk S.D., Yurdagul Jr. A., Albert P., Traylor Jr. J.G., Jin L., Chen J., and #A.W. Orr. (2012) EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis. Keystone Symposia: Molecular Basis of Vascular Inflammation and Atherosclerosis. Big Sky, MO, March 2012.

A. Wayne Orr

88. Chen J., Mazar A.P., and A.W. Orr. Shear stress-induced pro-inflammatory responses on transitional matrices requires αv integrins but not α5β1. Arterioscler. Thromb. Vasc. Biol. Conference 2012. Chicago, IL, April 2012.

89. Chen J., Mazar A.P., and A.W. Orr. Shear stress-induced pro-inflammatory responses on transitional matrices requires αv integrins but not α5β1. 7th International Conference on Biomechanics in Vascular Biology and Cardiovascular Disease, Atlanta, GA, April 2012.

90. #Yurdagul Jr. A., Albert P., and A.W. Orr. Matrix composition tunes the endothelial cell response to oxidized LDL between apoptosis and inflammation. South Central Chapter Society of Toxicology Fall Meeting, Starkville, MS, October 2012.

91. Yurdagul Jr. A., Chen J., Funk S.D., Albert P., Kevil C.G., and A.W. Orr. Altered nitric oxide

production mediates matrix-specific PAK2 and NF-B activation by flow. American Society for Matrix Biology Meeting, San Diego, CA, November 2012.

92. Funk S.D., Yurdagul Jr. A., Green J., Albert P., McInnis M., Chen J., Kevil C.G., and A.W. Orr. Deletion of the neuronal guidance molecule EphA2 reduces inflammation in experimental atherosclerosis. Vascular Cell Biology Gordon Conference, Ventura, CA, January 2013.

93. Green J., Yurdagul Jr. A., Chen J., Mazar A.P., and A.W. Orr. Hyperglycemia promotes 51 integrin activation to drive endothelial fibronectin deposition and early atherogenesis. Fibronectin, Integrins, and Related Molecules Gordon Conference, Ventura, CA, February 2013.

94. #Yurdagul Jr. A., Albert P., Mazar A.P., and A.W.Orr. Matrix composition modulates oxidized LDL-induced inflammation. Fibronectin, Integrins, and Related Molecules Gordon Conference, Ventura, CA, February 2013.

95. #Chen J., Mazar A.P., and A.W. Orr. Shear stress-induced pro-inflammatory responses on

transitional matrices requires αv integrins but not α5. Fibronectin, Integrins, and Related Molecules Gordon Conference, Ventura, CA, February 2013.

96. Funk S.D., Yurdagul Jr. A., Green J., Albert P., McInnis M., Chen J., Kevil C.G., and #A.W. Orr. Deletion of the neuronal guidance molecule EphA2 reduces inflammation in experimental atherogenesis. Arterioscler. Thromb. Vasc. Biol. Conference 2013. Orlando, FL, May 2013.

97. Chen J., Green J., McInnis M., Traylor Jr. J.G., Mazar A.P., and A.W. Orr. v3 integrins mediate shear stress-induced inflammation and early atherogenesis. Arterioscler. Thromb. Vasc. Biol. Conference 2013. Orlando, FL, May 2013.

98. Chen J.*, Green J., Albert P., McInnis M, and A.W. Orr. Shear stress-induced pro-inflammatory responses on transitional matrices requires αv integrins but not α5. NAVBO Workshops in Vascular Biology 2013. Hyannis, MA, October 2013. * NAVBO Poster Award winner.

99. Yurdagul Jr. A., Albert P., Mazar A.P., and A.W.Orr. Matrix composition modulates oxidized LDL-induced inflammation. NAVBO Workshops in Vascular Biology 2013. Hyannis, MA, October 2013.

100. Funk S.D., Yurdagul Jr. A., Green J., Albert P., McInnis M., Chen J., Kevil C.G., and A.W. Orr.

Deletion of the neuronal guidance molecule EphA2 reduces inflammation in experimental atherogenesis. NAVBO Workshops in Vascular Biology 2013. Hyannis, MA, October 2013.

A. Wayne Orr

101. Chen J., Leskova I., Albert P., Kevil C.G., Stokes K., and A.W.Orr. Nck modulates oxidant driven endothelial cell inflammatory response during ischemia-reperfusion injury. NAVBO Workshops in Vascular Biology 2013. Hyannis, MA, October 2013.

102. Funk S.D., Yurdagul Jr. A., Green J., Albert P., McInnis M., Chen J., Kevil C.G., and A.W. Orr.

Deletion of the neuronal guidance molecule EphA2 reduces inflammation in experimental atherogenesis. AHA Scientific Session 2013. Dallas, TX, November 2013. * Best of ATVB 2013 Selection.

103. Yurdagul Jr. A., Albert P., Mazar A.P., and A.W.Orr. Matrix composition modulates oxidized LDL-induced inflammation. ASCB 2014. New Orleans, LA, December 2013.

104. Yurdagul Jr. A., Albert P., Mazar A.P., and A.W.Orr. Matrix composition modulates oxidized LDL-induced inflammation. ATVB 2014, Toronto, Canada, May 2014.

105. Chen J., Leskova I., Albert P., Kevil C.G., Stokes K., and A.W.Orr. Nck modulates oxidant

driven endothelial cell inflammatory response during ischemia-reperfusion injury. ATVB 2014, Toronto, Canada, May 2014

106. Yurdagul Jr. A. and A.W. Orr. FAK-dependent endothelial cell activation by oxidized LDL requires p90Rsk. NAVBO Vascular Biology 2014. Pacific Grove, CA.

107. Yurdagul Jr. A. and A.W. Orr. FAK-dependent endothelial cell activation by oxidized LDL requires p90Rsk. Vascular Cell Biology Gordon Research Conference. Ventura, CA.

108. Yurdagul Jr. A., Green J., and A.W. Orr. Endothelial 5 integrins regulate oxLDL-induced fibronectin deposition, proinflammatory gene expression, and early atherogenic inflammation. Vascular Cell Biology Gordon Research Conference. Ventura, CA.

109. Yurdagul Jr. A., Green J., and A.W. Orr. Endothelial 5 integrins regulate oxLDL-induced fibronectin deposition, proinflammatory gene expression, and early atherogenic inflammation. ATVB 2015, San Francisco, CA, May 2015.

110. Yuan S., Yurdagul Jr. A., Orr A.W., and C.G. Kevil. Hydrogen sulfide increases endothelial permeability through sulfane sulfur modification of occludin. ATVB 2015, San Francisco, CA, May 2015.

111. Navratil A.R., Vozenilek A.E., Cardelli J.A., Green J.M., Orr A.W., and M.D. Woolard. Lipin-1 links proinflammatory responses and foam cell formation by oxidized-low density lipoprotein elicited macrophages. ATVB 2015, San Francisco, CA, May 2015.

112. Yurdagul Jr. A. and A.W. Orr. FAK-dependent endothelial cell activation by oxidized LDL

requires p90Rsk. NAVBO Vascular Biology 2015, Hyannis, MA.

113. Yurdagul Jr. A., Green J., and A.W. Orr. Endothelial 5 integrins regulate oxLDL-induced fibronectin deposition, proinflammatory gene expression, and early atherogenic inflammation. NAVBO Vascular Biology 2015, Hyannis, MA.

114. Funk S.D., Finney A.C., Yurdagul Jr. A., Green J., Albert P., McInnis M., Chen J., Kevil C.G., and A.W. Orr. Deletion of the neuronal guidance molecule EphA2 reduces inflammation in experimental atherogenesis. NAVBO Vascular Biology 2015, Hyannis, MA.

A. Wayne Orr

Other scholarly contributions

115. A.W. Orr. (2013) Integrin signaling in shear stress-induced endothelial cell dysfunction. Abcam review.

116. Yurdagul Jr. A. and A.W. Orr. (2013) Protein kinase A, nitric oxide, and atherosclerosis: is the answer in the basement. The Matrix Letter. 12 (1): 2.

117. Turk J.R. and A.W. Orr. (2014) Exposure of endothelial cells to hemodynamic shear stress in vitro is necessary for in vivo [or clinical] translation of responses. Toxicological Sci.

118. Orr A.W., Yurdagul Jr. A., and B.M. Patel. Pathogenesis of Atherosclerosis: From Cell Biology

to Therapeutics. Morgan & Claypool; 2014.

SEMINARS AT NATIONAL MEETINGS

Date Title, Meeting, Location

1. 05/16 H2S and Flow-Mediated Vascular Remodeling. 11th Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease. Atlanta, GA.

2. 02/16 H2S and Flow-Mediated Vascular Remodeling. Oxygen Radicals as Effectors of Redox Biology Gordon Research Conference 2016. Ventura, CA.

3. 10/14 Recruitment of the Nck adaptor protein to PECAM-1 couples oxidant stress to canonical

NF-B signaling and inflammation. NAVBO Vascular Biology 2014. Pacific Grove, CA.

4. 07/14 Shear stress-induced proinflammatory responses require v integrins but not 5. 7th World Congress of Biomechanics. Boston, MA.

5. 05/13 Deletion of the Neuronal Guidance Molecule EphA2 Reduces Inflammation in Experimental Atherosclerosis. Arterioscler. Thromb. Vasc. Biol. Conference 2013. Orlando, FL.

6. 03/12 EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis. Keystone Symposium: Molecular Basis of Vascular Inflammation and Atherosclerosis, Big Sky, MO.

7. 04/11 Basement membrane proteins enhance flow-induced nitric oxide production to limit NF-

B activation. Arterioscler. Thromb. Vasc. Biol. Conference 2011. Chicago, IL. 8. 02/11 Role of integrins in the endothelial response to flow. Vascular Cell Biology Gordon

Research Conference. Ventura, CA. 9. 04/09 Integrin signaling in the endothelial response to shear stress. Experimental Biology

2009. New Orleans, LA.

10. 09/08 PAK regulates oxidant-dependent NF-B activation by flow. Workshop: Biology of Signaling in the Cardiovascular System, Hyannis, MA.

11. 04/07 Matrix-specific PAK signaling regulates vascular permeability in atherogenesis. Minisymposium: Extracellular Matrix on Multiple Biological Scales, Experimental Biology 2007, Washington, D.C.

12. 09/03 Differential integrin signaling in response to endothelial shear stress. 4th Annual Colloquium on Cell Adhesion and Biomechanics. Charlottesville, VA.

13. 06/00 Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. Thrombospondin International Meeting 2000, Madison, WI.

DEPARTMENTAL SEMINARS

Date Title, Meeting, Location

A. Wayne Orr

1. 03/16 Integrin signaling in endothelial cell activation and early atherosclerosis. Cardiovascular Research Center. University of Virginia.

2. 09/15 Integrin signaling in endothelial cell activation and early atherosclerosis. Department of Biochemistry. LSU Health Sciences Center – Shreveport.

3. 03/15 Eph/ephrin signaling in atherogenic inflammation. Department of Microbiology. LSU Health Sciences Center – Shreveport.

4. 02/15 Integrin signaling in endothelial cell activation and early atherosclerosis. Department of Pharmacology. Tulane University School of Medicine.

5. 12/14 Integrin signaling in endothelial cell activation and early atherosclerosis. Department of Physiology. LSU Health Sciences Center – Shreveport.

6. 09/14 Integrin signaling in endothelial cell activation and early atherosclerosis. Department of Pathology, University of Toronto. Toronto, Canada.

7. 09/13 Integrin signaling in endothelial activation and early atherosclerosis. Department of Health and Human Performance, Dublin City University, Dublin, Ireland.

8. 06/13 Deletion of the neuronal guidance molecule EphA2 reduces inflammation in experimental atherosclerosis. Resident Research Day, Department of Pathology, Shreveport, LA.

9. 12/12 EphA guidance molecules in atherosclerosis: novel players in the inflammatory response. Department of Pharmacology, LSU Health Sciences Center, Shreveport, LA.

10. 12/12 Neuronal guidance molecules in atherosclerosis: novel players in the inflammatory response. Louisiana State University-Shreveport, Shreveport, LA.

11. 09/12 The endothelial cell matrix in early atherogenesis. Department of Pathology, LSU Health Sciences Center, New Orleans, LA.

12. 10/11 The endothelial cell matrix in early atherogenesis. Department of Cell Biology and Anatomy, LSU Health Sciences Center, Shreveport, LA.

13. 04/11 On solid ground: How basement membrane proteins limit endothelial cell dysfunction. Department of Physiology, LSU Health Sciences Center, Shreveport, LA.

14. 03/11 On solid ground: How basement membrane proteins limit endothelial cell dysfunction. Department of Biological Sciences, University of Memphis, Memphis, TN.

15. 04/10 EphA2 in the endothelial inflammatory response: a potential regulator of atherosclerosis. Louisiana State University-Shreveport, Shreveport, LA.

16. 10/09 Matrix signaling in the endothelial cell response to flow. Department of Biomedical Engineering, Texas A&M, College Station, TX.

17. 10/09 Matrix signaling in endothelial cell activation. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL.

18. 09/09 Matrix signaling in endothelial cell activation. Department of Biochemistry, LSU Health Sciences Center, Shreveport, LA.

19. 05/09 Matrix-specific signaling in the endothelial cell response to flow. Department of Molecular and Cellular Medicine, Texas A&M, College Station, TX.

20. 10/08 Matrix signaling in atherogenesis: breaking away from the PAK. Department of Pharmacology, LSUHSC, New Orleans, LA.

21. 09/08 Matrix signaling in atherogenesis: breaking away from the PAK. Louisiana State University-Shreveport, Shreveport, LA.

22. 01/08 Atheroprotective role of the basement membrane: breaking away from the PAK. Physiology Department, Louisiana State University Health Sciences Center, Shreveport, LA.

23. 09/07 Protective role of the basement membrane in endothelial cell dysfunction: breaking away from the PAK. Research in Progress seminar, Charlottesville, VA.

24. 05/07 Role of the subendothelial matrix in atherogenesis. Department of Biomedical Sciences, University of Missouri, Columbia, MO.

25. 05/07 Role of the subendothelial matrix in atherogenesis. Pathology Department, Louisiana State University Health Sciences Center, Shreveport, LA.

26. 02/07 Role of the subendothelial matrix in atherogenesis. Microbiology Department, University of Virginia, Charlottesville, VA.

A. Wayne Orr

27. 02/07 Role of the subendothelial matrix in atherogenesis. Physiology Department, Louisiana State University Health Sciences Center, Shreveport, LA.

28. 09/06 Regulation of endothelial dysfunction and atherogenesis by the subendothelial matrix. Cardiovascular Division Research Conferences, Charlottesville, VA.

29. 06/06 Matrix-specific PAK signaling regulates vascular permeability in atherogenesis. Robert M. Berne CVRC Retreat 2006, Wintergreen, VA.

30. 06/05 The subendothelial extracellular matrix modulates NF-B activation by flow: a potential role in atherosclerosis. Research in Progress seminar, Charlottesville, VA.

31. 10/02 Signaling thrombospondin-induced intermediate adhesion and its effect on endothelial cell migration. Dept Pathology, University of Alabama at Birmingham, Birmingham, AL.

STUDENTS AND TRAINEES

Date Student Degree Dept My Role Current

High School and Undergraduate Students

2013- 2014

Cathy Tran SMART student

Research Adviser Parkview High

School

Integrin signaling to Gs

2012- 2013

Joshua Ursua SMART student

Research Adviser Univ of Texas-

Austin

Focal adhesion kinase signaling in the endothelial response to oxLDL.

2011- 2012

Ruth Bishop SMART student

Research Adviser University of

Alabama

Cooperativity between matrix-dependent and RAGE-dependent signaling in diabetes

2010- 2011

Sean Mathews SMART student

Research Adviser Emory

University

EphA2 proinflammatory signaling in endothelial cells.

2009- 2010

Carson Allgood SMART student

Research Adviser LSU

EphA2 expression during atherosclerosis in vivo.

2008- 2009

Patrick Albert SMART student

Research Adviser LSUHSC-S

Medical School

Ephrin expression in endothelial cell dysfunction

2014 Rahim Sindhwani LBRN student Research Adviser LSU –

Shreveport

Role of hydrogen sulfide in the endothelial wound healing response.

Medical and Graduate Students

2014 Sydney Lee Medical Student


Regulation of hypertriglyceridemia in EphA2 deficient mice.

2014 Gene Robichaux Medical Student


Extracellular matrix production by oxidized LDL.

2015 Miriam L. Henry Medical Student


EphA2 in smooth muscle fibrotic gene expression

2015 Beau D. Foxworth Medical Student


Endothelial 5 integrins in early atherosclerosis

A. Wayne Orr

2016 Kimberly Le Blanc Medical Student


EphA2 in diet-induced hepatic injury.

2013 Sergio Cananzi PhD

candidate

Cell Biol and

Anatomy Rotation Research Adviser

Shear stress signaling through Gs.

2012 Morgan Manuel Masters Student

Cell Biol and


Shear stress and resveratrol in endothelial wound healing.

2012 Shuai Yuan PhD

candidate

Cell Biol and


Matrix specific activation of protein kinase G by shear stress.

2010- 2011

Shu Yang MS

candidate

Cell Biol and


M.S., Research

Associate – LSU

Matrix-specific PKA activation by shear stress

2015- current

Jonette Green PhD

candidate

Cell Biol and

Anatomy

Rotation and Dissertation Research Adviser

Integrin-specific signaling in endothelial cell activation.

2013- current

Alexandra Finney PhD

candidate

Cell Biol and

Anatomy


EphA2 signaling in smooth muscle cell function.

2011- 2015

Arif Yurdagul Jr. PhD

candidate

Cell Biol and

Anatomy


PhD, Postdoctoral

Fellow - Columbia University

Matrix regulation of oxidized LDL-induced endothelial cell activation

2010- 2011

Aaron Pitre PhD

candidate

Cell Biol and

Anatomy

Dissertation Research Co-Advisor

PhD, Postdoctoral

Fellow - St. Jude’s

Synemin regulation of astrocytoma cell proliferation and survival

2008- 2013

Steven Funk PhD

candidate

Cell Biol and

Anatomy

Rotation and Dissertation Research Advisor

PhD, Postdoctoral

Fellow – Washington University

EphA2 signaling in endothelial cell dysfunction and atherosclerosis

Post-degree trainees

2010- 2014

Jie Chen, Ph.D. Post-doctoral

Fellow Pathology Research Advisor

Postdoctoral Fellow –

LSUHSC-S

2013- 2014

Mohammad Rana, M.D. Fellow Cardiology Research Advisor

2013- 2014

Joshua Jordan, M.D. Resident Medicine Research Advisor

2015- 2016

Erin Langford, MD Resident Pathology Research Advisor

A. Wayne Orr

2015- 2016

Rebecca Pistorius, MD Resident Pathology Research Advisor

TEACHING

Date Role Course Total lectures

LSU Health Sciences Center - Shreveport

11/2008 Lecturer CEBIO 230: Experimental Cell Biology 2 week block

07/2010- Present

Course Co-Director PYAS 6554: Pathology

2011, 2012 Lecturer Cardiology: Vascular Biology of Atherosclerosis 1 lecture

08/2011- Present Lecturer PYAS 6554: Pathology (Cellular Pathology) 1 lecture

03/2012- Present Lecturer IDSP114: Cell Biology (Cell Motility and Migration) 2 lectures

08/2012- Present Mentor Module I: Small Group Alternative Mentor

10/2012- Present Lecturer Module I, Course 2: Extracellular Matrix Signaling 1 lecture

1/2013 Course Director CEBIO 289: Current Topics in Cell Biology

11/2013- Present Lecturer

Module I, Course 2: Signal Transduction I: Overview; Signal Transduction II: G Protein Linked Receptors; Signal Transduction III: Second Messangers, Ca++, and PIP cascades; Signal Transduction IV: Receptor tyrosine kinases 4 lectures

9/2014- Present Lecturer

PHY 234: Reactive Oxygen Species. NF-B and MAP Kinase signaling lectures 2 lectures

University of Virginia

11/2006 Lecturer BIMS 853: Modern Lit. Cardiovascular Res. 4 lectures

03/2004- 12/2007

Organizer/ Group Leader

Mechanotransduction Journal Club N/A

GRADUATE COMMITTEES Thesis Committee Steven Funk, Department of Cell Biology and Anatomy Thesis Committee Aaron Pitre, Department of Cell Biology and Anatomy Thesis Committee Shilpa Bhatia, Department of Cell Biology and Anatomy Thesis Committee James Kleinedler, Department of Pharmacology Thesis Committee Hany Sakr, Department of Cell Biology and Anatomy Thesis Committee Terrel Sugar, Department of Cell Biology and Anatomy Thesis Committee Shuai Yuan, Department of Cell Biology and Anatomy Thesis Committee Arif Yurdagul Jr., Department of Cell Biology and Anatomy Thesis Committee Priya Prasai, Department of Physiology Thesis Committee Aimee Vozenilek, Department of Microbiology and Anatomy Thesis Committee Alexandra Finney, Department of Cell Biology and Anatomy Qualifying Exam Deepak Pakalapati, Department of Cell Biology and Anatomy

A. Wayne Orr

Qualifying Exam Yoshinobu Odaka, Department of Cell Biology and Anatomy Qualifying Exam Shu Yang, Department of Cell Biology and Anatomy Qualifying Exam Shuai Yuan, Department of Cell Biology and Anatomy Qualifying Exam Arif Yurdagul Jr., Department of Cell Biology and Anatomy Qualifying Exam Stephanie Villalba, Department of Cell Biology and Anatomy Qualifying Exam Kimberly McCarter, Department of Cell Biology and Anatomy Qualifying Exam Natalie Hendrix, Department of Cell Biology and Anatomy Qualifying Exam Sergio Cananzi, Department of Cell Biology and Anatomy Qualifying Exam Aimee Vozenilek, Department of Microbiology and Anatomy Qualifying Exam Alexandra Finney, Department of Cell Biology and Anatomy Viva voce Brian MacDonnell, Dublin City University, Dublin, Ireland SERVICE LSU Health Sciences Center - Shreveport May, 2008- Present Floor Representative for the Sixth Floor of the Biomedical

Research Institute July, 2009- Present Member of the Institutional Research Advisory Committee July, 2009- July, 2010 Member of the Institutional Review Board July, 2010- Present Member of the Institutional Animal Care and Use Committee;

Vice-Chair (2011-2013), Chair (2013-2015) April, 2011- Present Graduate Committee, Department of Cell Biology and Anatomy,

LSUHSC-S May, 2011, 2012, 2015 Judge for Resident Research Day in the Department of Pathology April, 2012 August, 2012 Member, Committee for Research Space Allocation July, 2012- 2014 Faculty Senate, LSU Health Sciences Center – Shreveport July, 2013- Present Member, Pathology Program Review/Education Curriculum

Committee August, 2013- Present Coordinator, Malcolm Feist Cardiovascular Seminar Series National and International Service April 2010- Present Reviewer, American Heart Association Vascular Wall Biology or

Endothelial Cell Biology study sections (co-chair of Endothelial Cell Biology 3 study section since January 2015)

November, 2010- 2013 Member of the ATVB Early Career Committee, American Heart Association

July, 2011- 2013 Judge for ATVB Early Career Award January, 2012- Present Reviewer, American Diabetes Association, Basic 2 Study Section April, 2012 Mock Study Section, AHA Early Career Committee, ATVB

Scientific Sessions 2012 April, 2012 Round table discussion: Negotiating a startup package as a

career scientist, AHA Early Career Committee, ATVB Scientific Sessions 2012

February, 2013- 2016 Abstract Grader, ATVB Conference May, 2013 Round table discussion: Managing Your First Laboratory, AHA

Early Career Committee, ATVB Scientific Sessions 2012 October, 2013- Poster Judge, NAVBO Vascular Biology 2013, 2014 November, 2013 Present Member, NAVBO Membership Committee November, 2013 Present NAVBO Representative for LSU July, 2014- Present Member of the ATVB Membership and Communications

Committee, American Heart Association July 2014- Present Research College and Advisory Council, Dublin City University

A. Wayne Orr

Dublin, Ireland. July 2014 Ad hoc reviewer, Research Councils United Kingdom (RCUK) December 2014 Ad hoc reviewer, Council for the Earth and Life Sciences,

Netherlands Organization for Scientific Research (NWO) June, 2015 Ad hoc reviewer, Atherosclerosis and Inflammation in the

Cardiovascular System (AICS) Study Session, NIH Reviewer for journals: American Journal of Pathology, American Journal of Physiology – Lung Cellular and Molecular Physiology; Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB); Atherosclerosis; Biochemica et Biophysica - Molecular Cell Research; Biophysics Journal; BMC Immunology, BMC Physiology, Cardiovascular Diabetology, Cardiovascular Research, Circulation Research, International Journal of Cell Biology, International Journal of Vascular Medicine, Journal of the American Society for Nephrology, Journal of Cell Science; Journal of Biological Chemistry, Journal of the Royal Society Interface, Journal of Molecular and Cellular Cardiology, Laboratory Investigation, PLOS One, Science Signaling.

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