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A Modern Approach to Controlling ICP Spray Chamber Temperature Jerry Dulude, Glass Expansion, jdulude@geicp.com Slide 2 Glass Expansion www.geicp.com 1 Limitations of Externally Controlled Spray Chambers Requires antifreeze solution Requires bulky floor model chiller Cumbersome coolant lines from chiller to chamber Freezing of condensate on lines Requires intricate jacketed chamber Slide 3 Glass Expansion www.geicp.com 1 Limitations of other Peltier Controlled Spray Chambers Lack of programmability Insufficient cooling Require external fluid supply Limited temperature range Limited compatibility Slide 4 Glass Expansion www.geicp.com 1 IsoMist Programmable Temperature Spray Chamber Slide 5 Glass Expansion www.geicp.com 1 Features of IsoMist Powerful Peltier-effect chiller reaches -5C in 15 minutes Programmable from -10 to 60C in 1 degree increments Maintains temperature to within 0.1 degree Compact design (7.5x4x4 inches) 100% self-contained (no external lines) Incorporates Bluetooth technology for clean wireless control (USB available) Slide 6 Glass Expansion www.geicp.com 1 PC Screen showing IsoMist Software Slide 7 Glass Expansion www.geicp.com 1 Variety of Cyclonic Spray Chambers Borosilicate glass: most aqueous and organic applications Quartz: Trace boron determinations PFA: HF and ultra trace applications Slide 8 Glass Expansion www.geicp.com 1 Applications of the IsoMist Analyze volatile solvents Low temp. Reduce oxide interferences Low temp. Lower detection limits High temp. Increase stability Constant temp. Slide 9 Glass Expansion www.geicp.com 1 Determination of Trace Metals in Naphtha Interfere with the cracking process Poisoning of the catalysts Environmental release concerns Origin and migration markers Slide 10 Glass Expansion www.geicp.com 1 Spike Recoveries in Light Naphtha Direct (no dilution) Slide 11 Glass Expansion www.geicp.com 1 Oxide Reduction in ICP-MS Isobaric oxide interferences Element/IsotopeInterference 56 Fe 40 Ar 16 O + 51 V +35 Cl 16 O + 44 Ca +14 N 14 N 16 O + 48 Ti +32 S 16 O + 52 Cr +34 S 18 O + 64 Zn +32 S 16 O 16 O + 64 Zn +48 Ca 16 O + Robert Thomas, Practical Guide to ICP-MS, Marcel Dekker, NY, 2004. Slide 12 Glass Expansion www.geicp.com 1 Reducing Oxides for ICP-MS Data courtesy of David Jones, ALS Chemex, Brisbane, Australia Slide 13 Glass Expansion www.geicp.com 1 Analysis of Limited Sample Volumes Biological applications Intracellular fluids Neonatal samples Forensic applications Requires micro flow nebulization Low DLs desirable Slide 14 Glass Expansion www.geicp.com 1 Effect of Temperature on Normalized LOD ( 20ul/min Uptake) PE Optima 2100DV Slide 15 Glass Expansion www.geicp.com 1 Constant temperature benefits Environmental monitoring Tighter CCVs Fewer QCs Higher productivity Metal assays Tighter bracketing Higher accuracy Slide 16 Glass Expansion www.geicp.com 1 IsoMist Customization PE ICP & ICP-MS Varian ICP & ICP-MS Agilent ICP-MS ThermoFisher ICP & ICP-MS Horiba J-Y ICP Teledyne Leeman ICP GBC ICP Spectro ICP Borosilicate glass Quartz Inert PFA Models Spray Chamber Materials Slide 17 Glass Expansion www.geicp.com 1 Chassis Configurations of IsoMist Slide 18 Glass Expansion www.geicp.com 1 IsoMist on Optima 2100DV Slide 19 Glass Expansion www.geicp.com 1 IsoMist on Optima 2100DV Slide 20 Glass Expansion www.geicp.com 1 IsoMist on the Agilent 7500 ICP-MS Slide 21 Glass Expansion www.geicp.com 1 IsoMist on the Varian Vista MPX Slide 22 Glass Expansion www.geicp.com 1 IsoMist on the Varian Vista MPX Slide 23 Glass Expansion www.geicp.com 1 IsoMist on the Thermo iCAP 6500DV Slide 24 Glass Expansion www.geicp.com 1 IsoMist on the PE Elan 9000 Slide 25 Glass Expansion www.geicp.com 1 IsoMist on the PE Elan 9000 Slide 26 Glass Expansion www.geicp.com 1 Summary Control of Spray chamber temperature enhances the capability of your ICP. The IsoMist is easily installed. The IsoMist is easily and precisely controlled. Compatible with all major ICP-OES & ICP-MS models.