A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands...

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A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force Florencia Rosetti, Yunfeng Chen, Mehmet Sen, Elizabeth Thayer, Veronica Azcutia, Jan M. Herter, F. William Luscinskas, Xavier Cullere, Cheng Zhu, Tanya N. Mayadas Cell Reports Volume 10, Issue 10, Pages 1655-1664 (March 2015) DOI: 10.1016/j.celrep.2015.02.037 Copyright © 2015 The Authors Terms and Conditions

Transcript of A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands...

Page 1: A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force Florencia Rosetti, Yunfeng Chen, Mehmet Sen,

A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force 

Florencia Rosetti, Yunfeng Chen, Mehmet Sen, Elizabeth Thayer, Veronica Azcutia, Jan M. Herter, F. William Luscinskas, Xavier Cullere, Cheng Zhu, Tanya N. Mayadas 

Cell Reports Volume 10, Issue 10, Pages 1655-1664 (March 2015)

DOI: 10.1016/j.celrep.2015.02.037

Copyright © 2015 The Authors Terms and Conditions

Page 2: A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force Florencia Rosetti, Yunfeng Chen, Mehmet Sen,

Figure 1

Cell Reports 2015 10, 1655-1664DOI: (10.1016/j.celrep.2015.02.037) Copyright © 2015 The Authors Terms and Conditions

Page 3: A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force Florencia Rosetti, Yunfeng Chen, Mehmet Sen,

Figure 2

Cell Reports 2015 10, 1655-1664DOI: (10.1016/j.celrep.2015.02.037) Copyright © 2015 The Authors Terms and Conditions

Page 4: A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force Florencia Rosetti, Yunfeng Chen, Mehmet Sen,

Figure 3

Cell Reports 2015 10, 1655-1664DOI: (10.1016/j.celrep.2015.02.037) Copyright © 2015 The Authors Terms and Conditions

Page 5: A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force Florencia Rosetti, Yunfeng Chen, Mehmet Sen,

Figure 4

Cell Reports 2015 10, 1655-1664DOI: (10.1016/j.celrep.2015.02.037) Copyright © 2015 The Authors Terms and Conditions

Page 6: A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force Florencia Rosetti, Yunfeng Chen, Mehmet Sen,

Cell Reports 2015 10, 1655-1664DOI: (10.1016/j.celrep.2015.02.037) Copyright © 2015 The Authors Terms and Conditions