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Transcript of A HIERARCHY OF EVIDENCE WITHIN THE SCHOLARLY LITERATURE Shelly Warwick, Ph.D. 2012 – Permission is...
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A HIERARCHY OF EVIDENCE WITHIN THE SCHOLARLY LITERATURE
Shelly Warwick, Ph.D.
2012 – Permission is granted to reproduce and edit this work for non-commercial educational use as long as attribution is provided and the edited work is also available under the same terms of license.
![Page 2: A HIERARCHY OF EVIDENCE WITHIN THE SCHOLARLY LITERATURE Shelly Warwick, Ph.D. 2012 – Permission is granted to reproduce and edit this work for non-commercial.](https://reader036.fdocuments.us/reader036/viewer/2022083008/56649d745503460f94a54a2f/html5/thumbnails/2.jpg)
After this Unit You Should Be Able toKnow where each type of study falls within
the evidence hierarchy.Explain the difference between a narrative
review, systematic review and meta-analysis.Select the correct study type(s) to answer a
specific research question.
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Remember the Evidence Hierarchy
The top of the pyramid is best – but if high level studies aren’t available – use what is
Animal Research
Case Series/Case Reports
Randomized Controlled Trials
Cohort Studies
Systematic Reviews
Case Control Studies
Meta Analysis
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Differences in Study Types in the Pyramid -1
Animal Studies – studies using animals not humans
Case Series and Case Reports – reports of the treatment of individual patients or a single patient. No use of control group. No statistical validity.
Case Control Studies – retrospective studies comparing patients with a specific condition or outcome to those without the condition or outcome to determine exposures or causes. Can show statistical relationship but not necessarily a causal relationship.
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Differences in Study Types in the Pyramid -2.Cohort Studies – prospective observational studies of
patients already being treated or who have had exposure. Studied group is often compared to general population or similar population not treated.
Randomized Controlled Clinical Trials (RCT) – treatment of real patients under controlled conditions – including randomization to treatment or no treatment and blinding of which group the individual is assigned from both the patient and individual(s) providing follow-up and collecting results.
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Differences in Study Types in the Pyramid -3Systematic Reviews - based on extensive
exhaustive literature search to identify studies that focus on a highly defined question. Results summarized according to predetermined criteria. Not to be confused with Narrative Review articles that review recent literature on a topic but are usually not exhaustive.
Meta-analysis – goes beyond the Systematic Review to combining results of studies using accepted statistical methodology to produce a single conclusion.
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Use the Right Type of Study for Your Question
Type of Question
Suggested best type of study
Diagnosis prospective, blind comparison to a gold standard
Therapy RCT > cohort > case control > case series
Prognosis cohort study > case control > case series
Harm/Etiology
RCT > cohort > case control > case series
Prevention RCT > cohort study > case control > case series
Clinical Exam
prospective, blind comparison to gold standard
Cost Benefit economic analysis
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MOVE ON TO MODULE 5 – CONTROLLED VOCABULARIES