A clinical approach to Hemiplegia - scah.uct.ac.za clinical approach to Hemiplegia Dr. A.P.Ndondo...
Transcript of A clinical approach to Hemiplegia - scah.uct.ac.za clinical approach to Hemiplegia Dr. A.P.Ndondo...
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A clinical approach to
Hemiplegia
Dr. A.P.Ndondo
Paediatric Neurology Department
Red Cross Children’s Hospital
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Paralysis of one side of the body
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Involvement of corticospinal tract
on the opposite side� Cortex
� Corona radiata
� Internal capsule
Brain-stem� Brain-stem
- midbrain
- pons
- medulla
� Spinal cord
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Cortex
� Face + arm > leg
� Speech – if dominant hemisphere
� Seizures
� Cortical sensory involvement
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Internal capsule
� Dense hemiplegia
� Hemisensory loss
� Homonymous hemianopia
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Brainstem
� Crossed hemiplegia
� Ipsilateral CN palsy + opposite hemi
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Brainstem
� Weber syndrome = 3rd N + opp. hemi
(midbrain)
Millard-Gubler syndr. = 6th /7th + opp. hemi� Millard-Gubler syndr. = 6th /7th + opp. hemi
(pons)
� Jackson syndrome = 10th, 12th + opp. Hemi
(medulla)
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Spinal cord
� Face spared
� Cranial nerves not affected
� Hemisensory loss
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� Congenital hemiplegia / Infantile hemiplegia
� Acquired hemiplegia
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Congenital hemiplegia - causes
� Causes of hemiplegic CP
� Prenatal / perinatal insults
� Vascular
� Structural
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pictures
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Clues to congenital hemiplegia
� Asymmetric Moro
� Early handedness
� Smaller limb / hand (compare nail size)
Delayed motor milestones� Delayed motor milestones
� Falls to one side
� Cortical thumb
� 20-30% seizures
� +/- 30% ID
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Acquired hemiplegia
� Stroke
Non-vascular : stroke mimics� Non-vascular : stroke mimics
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Differential diagnosis in a child with acute
hemiplegia – ‘Stroke Mimics’
• Todd’s paralysis
• ADEM (Acute Disseminated EncephaloMyelitis)
• Mass lesions, eg. Neoplasms
• Trauma (NAI)• Trauma (NAI)
• HSV encephalitis
• PRES (Post. Reversible Encephalopathy Syndr.)
• Complicated migraine
• Metabolic eg.MELAS (Mitochondrial)
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Definitions
Stroke: Sudden occlusion or rupture
of cerebral arteries or veinsof cerebral arteries or veins
resulting in focal cerebral
damage and clinical
neurological deficits
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Clinical stroke
A focal neurological deficit lasting more than 24 hours, with neuroimaging evidence of
abnormality in an established vascular abnormality in an established vascular territory
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� The World Health Organization
‘a clinical syndrome typified by rapidly developing signs of focal or global disturbance of cerebral functions, lasting more than 24 hours or leading to death,with more than 24 hours or leading to death,with no apparent causes other than of vascular origin’
(World Health Organization 1978).
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Transient Ischaemic Attack
…… with deficits of < 24 hours
…….without neuroimaging…….without neuroimaging
abnormalities
(compare with Todd’s paralysis)
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Others
� Bland infarct
Haemorrhagic infarct� Haemorrhagic infarct
� Etc.
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Classification
• Haemorrhagic
• Ischaemic
• Venous (CSVT)
Arterial (AIS)• Arterial (AIS)
• Cardioembolic
• Thrombotic
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Arterial Ischaemic Stroke
� Perinatal / Neonatal Stroke
- 28weeks gest. => 1 month
� Childhood AIS
- 1 month => 18years
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Epidemiology
� Childhood stroke = 2.3 – 13/100 000
� Neonatal stroke increasing
*25 – 30/100 000 (ie.1/4000live births)
Lynch et al, 2002 (USA); Lee et al, 2005
� Boys > girls
Amlie-Lefond C et al, Lancet Neurol 2008
� Black > Asian > White (including mortality)Fullerton HJ et al, Neurology 2003
� Ischaemic > haemorrhagicAHA (Roach et al 2008) – 55% ischaemic
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Clinical presentation
� Infants may present with focal weakness
� More likely than older children present with:
- seizures- seizures
- altered level of consciousness
(Zimmer et al, 2007 – Age related variation in
clinical signs of childhood AIS)
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Clinical Presentation
Older children
� Hemiparesis
� Most commonly MCA territory� Most commonly MCA territory
� Other focal neurological deficits
� Aphasia / dysphasia
(Al-Sulaiman et al, 1999; Abram et al, 1996; Zimmer et al, 2007)
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Challenges in diagnosis
� Perceived to be rare – low index of suspicion
� Non-specific clinical cues
� Poor localization of signs in young children
� Misdiagnosis – ‘mimics’
� Availability of Neuroimaging
� Time delays
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Underlying mechanisms/Risk Factors
in Adults� Atherosclerosis
� Hypertension
� Smoking
� Atrial fibrillation
� Diabetes mellitus
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Risk factors
Intravascular Vascular Embolic
Haematologic
eg. Sickle cell disease
Vasculopathies
eg. Post-varicella (TCAC)
Moyamoya
Congenital heart disease
eg. Complex CHD
Prothrombotic states
Congenital:
eg. Protein S,C deficiency
Acquired:
eg. L-asparaginase
Anticardiolipin
Moyamoya
Vasculitis
eg. Meningitis,
SLE
Takayasu
Acquired Heart Disease
eg. Rheumatic HD
Infective endocard.
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Examples of Childhood Arterial
Ischaemic Stroke Risk Factors
Factors Examples
1. Cardiac - Congenital heart disease
- Valvular heart disease
- Cardiomyopathies
2. Cerebral arteriopathy - Focal cerebral arteriopathy2. Cerebral arteriopathy - Focal cerebral arteriopathy
- Moyamoya disease/syndrome
- Dissection
3. Infections - Varicella
- Meningitides
4. Haematological - Sickle cell disease
- Thrombophilias
- Iron deficiency anaemia
5. Genetic - Neurofibromatosis Type 1
- Homocystinuria
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Risk factors
� Hospital-based vs population-based
� Cardiac constitute about 30% (hospital)
� Cerebral Arteriopathy – 24%� Cerebral Arteriopathy – 24%
� Infection (meningitis, sepsis) – 23%
� Cardiac – 12%
� No identifiable cause – 27%
Fullerton et al, 2007 (n=97; Carlifornia)
� Thrombophilia (?); Sickle cell disease (3%)
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Risk factors
� Often a combination of factors in children
Lanthier, S, Carmant, L, David, M, et al. Stroke in children: The Lanthier, S, Carmant, L, David, M, et al. Stroke in children: The coexistence of multiple risk factors predicts poor outcome.
Neurology 2000; 54:371.
Strater, R, Vielhaber, H, Kassenbohmer, R, et al. Genetic risk factors of thrombophilia in ischaemic childhood stroke of cardiac origin. A prospective ESPED survey. Eur J Pediatr 1999; 158 Suppl 3:S122.
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Embolic
� Cardiac eg. Congenital HD
Large vessels eg. Dissection� Large vessels eg. Dissection
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Intravascular factors / Haematological
� Thrombophilias
� Sickle Cell disease (+ vascular)
� Iron Deficiency Anaemia
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Thrombophilias
� Isolated thrombophilias
� Primary or secondary?
� Combinations more important
� Venous vs arterial
� Type of thrombophilia
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Thrombophilias
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Vasculopathies
� FCA – Focal Cerebral Arteriopathy of
Childhood
� Post-varicella Arteriopathy
� (TCAC – Transient Cerebral� (TCAC – Transient Cerebral
Arteriopathy of Childhood)
� Moyamoya – Disease/Syndrome
� Vasculitis – cPACNS; post-infectious
� Arterial Dissection
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TCAC
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Moyamoya
� “Moyamoya” is a rare cerebrovascular disorder
� Involves stenosis or occlusion of terminal internal carotids
� There are collateral vessels at base of the brain
- best visualised on cerebral angiography
- appearance of “puff of smoke” hence the
Japanese term “Moyamoya”
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Moyamoya Disease
� Primary or Idiopathic form
� Seen mostly in Japan and East Asia
Estimated incidence:� Estimated incidence:
USA - 0.09/100 000 patient-years
Japan - 3-10/100 000 patient-years
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Moyamoya Syndrome
Secondary to the following:
� Down’s Syndrome
� Neurofibromatosis� Neurofibromatosis
� Sickle Cell Disease
� Homocystinuria
� Radiotherapy (brain)
� Infections (?HIV), etc.
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Moyamoya associated factors:
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Fig 1. MRI and MRA of patient with moyamoya and Down’s Syndrome
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Fig.2 MRAs of 2 patients with HIV and cerebral arteriopathy
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Vasculitis
� Primary or Secondary to systemic
disease
� CNS vasculitis in adults – 1959
� Primary CNS vasculitis of childhood
recently described
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Panel of Investigations
� Neuroimaging – CT vs MRI/MRA
(head & neck)
� Infection screening – including CSF
Echocardiography� Echocardiography
� Connective tissue screening
� Thrombophilia screening
� HIV testing (where clinically indicated)
� Metabolic (eg. Homocystinuria)
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Treatment
� Neuroprotective
� Antithrombotic
� Thrombolysis (experimental)
� Rehabilitation
� Revascularisation
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Acute management includes
� Oxygenation
� Perfusion / cerebral perfusion
Glycaemic control� Glycaemic control
� Temperature
� ? Anaemia correction
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Supportive care measures
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Antithrombotic Treatments
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Recommendations – Childhood AIS
� For secondary prevention in underlying cardiac disorders and vascular dissection:
- low molecular weight heparin
- these patients MUST be referred and - these patients MUST be referred and managed in conjunction with relevant specialists – cardiologist, haematologist, neurologist.
Growing evidence for heparin in CSVT
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Recommendations for Treatment of Cerebral VenousSinus Thrombosis
Class I Recommendations
� 1. Supportive measures for children with CVST should
include appropriate hydration, control of epileptic seizures,
and treatment of elevated intracranial pressure
(Class I, Level of Evidence C).
� 2. Children with CVST should have a complete blood
count
(Class I, Level of Evidence C).
� 3. Children with a CVST and a suspected bacterial infection
should receive appropriate antibiotics
(Class I, Level of Evidence C)
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Childhood AIS
� Low dose aspirin for children with AIS
� All patients with vasculopathy
� Patients with unknown aetiology
� ?Duration of aspirin
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Sickle cell disease - STOP
� Transfusions
� Target HbS <30%
� Transcranial Doppler
� Hydroxurea
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Thrombolysis (Hyperacute)
Bernard et al: Childhood AIS Treatment, Ann Neurol 2008
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Rehabilitation
• Physio
• OT
• Speech Therapy
� CIMT - Constraint-Induced Movement
Therapy
� TMS - Transcranial Magnetic
Stimulation
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Outcomes
� Normal
� Neurological deficits
� Epilepsy
� Death� Death
� Migraine
� NB: Pre-Wallerian degeneration on
Diffusion studies = poor prognosis
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Neurological deficit
Annals of Neurology Vol 63 No 6 June 2008
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Mortality
Annals of Neurology Vol 63 No 6 June 2008
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Recurrence
Annals of Neurology Vol 63 No 6 June 2008
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THANK YOU !!!