A CENTRIFUGATION-ENHANCED HIGH-EFFICIENCY MICRO-FILTERWITH SPIRAL CHANNEL

Xu Ji, Wei Wang, Xia Lou, Jianhong Peng, and Zhihong LiNational Key Laboratory of Micro/Nano Fabrication Technology

Institute of Microelectronics, Peking University, Beijing, 100871, China

(Transducers 2007 P.1865~1868)

Reporter: Chung-Kuang Chin ( 秦重光 )

Date:1/2/2008

Outline

Introduction Principle & Numerical Simulations Fabrication Experiments Results & Discussion

Introduction

Micro-filters/Separators－ Goal ： to separate, remove and pre-concentrate particles from original mixtures .－ usually employed prior to analysis in biologic and chemical diagnostic processes.－ Classification ： Active or Passive

Introduction (cont.)

Active micro-filters/Separators－運用靜電力、磁力、機械力 、介電泳力 (DEP) 、光鑷夾 ( 光場 )等來完成。

Introduction (cont.)

Passive micro-filters/Separators－純粹靠結構設計來過濾或分類。

Principle

Numerical Simulations

flux, which penetrates through the filtration wall, in a circle channel device is 2.25 times than that in thestraight channel filter at the same conditions.

Fabrication

Width:120μm

Pores:3.5μm

Depth:60μm

Experiments

7.2μL/S 60μL/S

7.2μL/S －＞ 1.2 : 1(number ratio of 大 :小 )60μL/S －＞ 1.6 : 1(number ratio of 大 :小 )

6.5:1

Results & Discussion

Ref: Separation of Blood in Microchannel Bends, C. Blattert¹, R. Jurischka¹,I. Tahhan¹, A. Schoth¹, P. Kerth², W. Menz¹ 1 Institut fuer Mikrosystemtechnik, Universitaet Freiburg, Germany 2PREVENTOR µTBC GmbH, Pfungstadt, Germany, IEEE 2003

1. Higher flow velocity allows higher filtration efficiency.

2. Large particles are remarkably enriched by several filtration circles.

Reference Review: Microfluidics technology for manipulation and analysis of biol

ogical cells, Changqing Yi, Cheuk-Wing Li, Shenglin Ji, Mengsu Yang, Analytica Chimica Acta, 2006

Separation of Blood in Microchannel Bends, C. Blattert¹, R. Jurischka¹,I. Tahhan¹, A. Schoth¹, P. Kerth², W. Menz¹ 1 Institut fuer Mikrosystemtechnik, Universitaet Freiburg, Germany 2PREVENTOR µTBC GmbH, Pfungstadt, Germany, IEEE 2003

THE END

Thanks for Your Attention!