83. Drogas Usadas Leishmaniasis, Tripanosomiasis y Toxoplasmosis

8/17/2019 83. Drogas Usadas Leishmaniasis, Tripanosomiasis y Toxoplasmosis

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UNIVERSIDAD CENTRAL DEL ECUADORFACULTAD DE CIENCIAS MÉDICAS

CARRERA DE MEDICINACÁTEDRA DE FARMACOLOGÍA

83. DROGAS USADAS: LEISHMANIASIS,

TRIPANOSOMIASIS Y TOXOPLASMOSISINTEGRANTES

Simba Góm! Ma"i#$i %a!m&'S()i* T(""* Rai*a N()ia

S#+"! Ci*'"(* Dia'a E*-a'&a

P7 – 5to

DR. ANTONIO SALAS


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L E I S H M AN I AS I S

FORMAS CLINICAS• CUTANEA L. m$i/a'a 0 L. b"a!i)i'*i*• MUCOCUTANEA L. "(1i/a), L. ma2(" L. a3i(1i/a• VICERAL L. 4('(5a'i, L. i'-a'#m 0 L.

/3a6a*i


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ANTIMONIALESPENTAVALENTES

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I'""' /(' )*i*ma "4($

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i'"a5'(*a

E$/"/ió' "'a)

Vi4a m4ia ;3

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6'"a)

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i'0//ió',"(mb(B 4&a*

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4 4&a*


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MILTEFOSINAEm1)a4( ')a*m+*a*i* '/+'/" 4*'(, /('"a1"((!((*

1a"a )a**1/i* 4)i*3ma'ia1a'am'*i* 06#0a''*i*

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>. I'"" )a*

*a)* /)#)a"*. bi(*&'*i* 4)6)#/(*i)-(*-ai4i)i'(*i()

La m#a/ió' ' )a/('-("ma/ió' 4 )a

)i1(1"(&'aATPa*a i1( P4"mi'a )aa1a"i/ió' 4"*i*'/ia


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A4mi'i*"a/ió' ("a)

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D )//ió' ' Li*3ma'ia*i*5i*/"a): >,m6@6@4&a 4i5i4i4a ' 4(*i* 1(" >B 4&a*


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PENTAMIDINA

P'ami4i'a, *i)mi4i'a 0 1"(mi4i'a *(' 4"i5a4(*4 )a 4iami4i'a

A4mi'i*"a/ió' i'"am#*/#)a" i'"a5'(*a,$/"/ió' "'a)

Vi4a m4ia ; 3I'""' ' )a

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N-"(($i/a, 31a(($i/a, *( "5"*ib)*/(' )a 4*/('i'#a/ió' 4) -+"ma/(

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P#4 3ab" )#/(1'ia, a'mia,"(mb(/i(1'ia, 3i1(6)i/mia,3i1(/a)/mia, 3i1"a)mia


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ANFOTERICINA J

a'ibiói/( 1()i'i/(#*a4( ' )

"aami'( 4 )a*

mi/(*i* *i*mi/a*,)i*3ma'ia*i*

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E$/"/ió' "'a)

7 I'3ib )(*

1"/#"*("* 4)"6(*"()


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TRATAMIENTO DE LA TRIPANOSOMIASIS

E'-"m4a4 4C3a6a* (

"i1a'(*(mia*i*am"i/a'a

P"(4#/i4a 1("1a"+*i(*


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TRATAMIENTO CHAGAS

NI"(-#"a'(* : 'i-#"im($ 0'i"(imi4a!()

SINTOMATOLOGÍA

Mi(/a"4i(1a&aM6a/()('

M6a*ó-a6( TRATAMIENTO T. AFRICANA

P'ami4i'a 0 *#"ami'a

E-/i5a* '-a* a6#4a (

3m()i'-+i/a


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NIFURTIM X7D"i5a4( 'i"(-#"a'(

EFECTOS FARMACOLÓGICOS

7A/a *(b" -("ma* i'"a 0"a/)#)a"*: T"i1a'(ma*i(* 0 ama*i6(*

MECANISMO DE ACCIÓN

7G'"a 1"(4#/(* "a/i5(* ($i4a':*#1"ó$i4(, 1"ó$i4( 4 3i4"ó6'( 0

"a4i/a)* 3i4"($i)(

7Daa )a mmb"a'a /)#)a"1a"a*ia"ia, i'a/i5a/ió' '!im+i/a,

4a( 4) ADN

FARMACOCINÉTICA

Ab*("/ió' 6a*"(i'*i'a)

S 4i*"ib#0 1(" (4(* )(* 2i4(* 0)&#i4(* /("1("a)*

Pa*a )a 1)a/'a 0 ) LCRE-/( 1"im" 1a*( ' ) 3&6a4(


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FARMACOPATOLOGÍAGastrointstina!s " A'("$ia D()(" ab4(mi'a)N+#*a* Vómi(

SNC" i'*(m'i(, /-a)a, ma"(, $/ia/ió', 4)i"i(,1*i/(*i*

#i$rsnsi%i!i&a&" 4"maii*, b", i/"i/ia,a'a)a$ia

USOS

F("ma a6#4a 4C3a6a* 0 i'

a/i5i4a4 /('"a )a'-"m4a4 4) *#(

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'iaD-("ma/ió'( 4i*mi'#/ió'

4*1"ma(!(i

4*


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JENKNIDAKOLMECANISMO DE

ACCIN

I'"" /(' )a *&'*i*4 ma/"(m()/#)a*

FARMACOCINÉTICA7Ab*("b ' "a/(6a*"(i'*i'a)

7S )imi'a "ió'

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FARMACOPATOLOGÍAN+#*a, 5ómi(, 4()("

ab4(mi'a),1()i'#"(1a&a 04"maii*, "a*3,

$a'ma*

INTERACCIONES

N( i'6"i" a)/(3()

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4 > a(*

USOS

A'i7 T. /"#!i, m2("()"a4( 1(" )(* 'i(*


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EFLORNITHINE A'+)(6( 4) ("'i3i' E*ab) 0 * ma'i' a m1"a#"a ambi' T"aa" '-"m4a4 4) *#( T. b.6ambi'*

EFECTOS FARMACOLGICOS

I'3ib i""5"*ib)m' )a '!ima("'i3i' 4*/a"b($i)a*a

I'""#m1i'4( )a *&'*i* 41()iami'a* "#"i4a* 1a"a )a 4i5i*ió'0 4i-"'/ia/ió'


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Fa"ma/(/i'i/a

Vi4am4ia 4

3("a*

E)imi'a/ió' "'a)

Ni(*)imi'a'

ma*

"+1i4(


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Fa"ma/(1a()(6&a

Hi1"*'*ibi)i

4a4

Vómi(D()("ab4(mi'a)


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U*(*

T"i1a'(*(miami* 3m()i'-ai/a

T"i1a'(*(miami*

m'i'6('/-a)ii/a


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Piri'ta'ina

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•Ab*("/ió' i'*i'a)•Vi4a m4ia 3("a*•Mab()i!a4a '3&6a4(•E)imi'a/ió' "'a)


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C('"ai'4i/a/i('*• Emba"a!( 8"

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E*1i"ami/i'a

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A#(5a#('• D"i5a4( 43i4"($i'a1(#i'('a

S#)-a4ia!i'a• E)imi'a/ió' "'a)• A"a5i*a ba"""a

3ma('/-+)i/a


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83. Drogas Usadas Leishmaniasis, Tripanosomiasis y Toxoplasmosis

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