7/23/99

NIH/NIGMS Support of Structural Biology

• NIH individual research grants with crystallography projects (FY 98)

– primary: 225 grants, $51M total costs

– secondary: 400 grants, $96M total costs

– NIGMS is 50% of each

• NIH program projects and NCRR research resources: approx. $30M for protein crystallography

7/23/99

NIGMS Initiative for Synchrotron Beamlines

• Beamline upgrades for benefit of general users

• Reports on increasing demand for user access and beamline needs

• Estimate of doubling of capacity for crystallographic experiments from staff increases and equipment upgrades

• Letter to synchrotron facility directors inviting informal proposals

• NIGMS synchrotron advisory group

• FY99 funding of $7M from NIGMS

7/23/99

Synchrotron Beamline Upgrades Supported by NIGMS

• upgrades to 4 beamlines• CCD detectors• computer• wet lab• four beamline scientists/technicians• one staff for new review/scheduling process• $1,770K equipment• $705K annual – staff

Stanford Synchrotron Research Laboratory

7/23/99

Synchrotron Beamline Upgrades Supported by NIGMS

• reconstruction of bending magnet beamline• ncluding beamline optics, monochrometer, detector,

crystallography station• four beamline scientists/technicians• $2,372K equipment/construction• $670K annual – staff

National Synchrotron Light Source

7/23/99

Synchrotron Beamline Upgrades Supported by NIGMS

• upgrades to three beamlines• beamline optics and cooling equipment, monochrometer,

automation/ monitors, computer• two beamline scientists• $1,238K equipment• $340K annual – staff

Cornell High Energy Synchrotron Source

7/23/99

Synchrotron Beamline Upgrades Supported by NIGMS

• upgrade to the focusing optics for one beamline and a detector• low temperature system and computer for a new beamline• four beamline scientists/ technicians• $963K equipment• $259K annual – staff

Advanced Light Source

7/23/99

Synchrotron Beamline Construction Supported by NIGMS

• construction of a new crystallographic beamline• two beamline scientists• cofunded with the NSF, Louisiana State University, and a consortium

of PIs in the southern U.S.• $1,260K construction/equipment (NIGMS & NSF)• $206K annual – staff (NIGMS & NSF)

Center for Advanced Microstructures and Devices

7/23/99

Synchrotron Beamline Construction Supported by NIGMS

• development of a new crystallographic sector of two crystallographic beamlines

• partnership with the NCI • two years of NIGMS/NCI funding for construction.• $18M construction/equipment (NIGMS & NCI)

Advanced Photon Source