7147621 Human Physiology
-
Upload
khaled71111 -
Category
Documents
-
view
226 -
download
0
Transcript of 7147621 Human Physiology
-
8/12/2019 7147621 Human Physiology
1/41
HUMAN PHYSIOLOGYAnita Ocampo-So, MD, FPSP, DPBA, MHA
Professor
-
8/12/2019 7147621 Human Physiology
2/41
GOALS
1 !o "n#erstan# t$e importantf"nctions of t$e %ario"s or&an
s'stems( !o ac)"ire t$e a*i+it' to pro*+em
so+%in& an# critica+ t$in in&
!o #iscern t$e %a+"e of +a*orator'e)"ipment an# proce#"res as#ia&nostic ai#s
-
8/12/2019 7147621 Human Physiology
3/41
GOALS
1 !o #e%e+op t$e attit"#e an# $a*itessentia+ to t$e practice of
me#icine an# contin"in& me#ica+e#"cationi Sensiti%it' to co++ea&"es, societ',
an# patientii Sensiti%it' to #ifferenceiii Sensiti%it' to responsi*i+it' to .M/i% Inte&rit'
-
8/12/2019 7147621 Human Physiology
4/41
PHYSIOLOGY
P$'sio+o&' state# *roa#+' an#simp+' is t$e st"#' of $o0
+i%in& or&anisms 0orIt #ea+s 0it$ t$e f"nctions of+i%in& *ein&s an# t$e
Inte&ration on $o0 t$e #ifferentor&an s'stems 0or to&et$er toaccomp+is$ comp+e tas s
-
8/12/2019 7147621 Human Physiology
5/41
PHYSIOLOGY
.+a"#e Bernar#2After carr'in& o"t an ana+'sis
of p$enomena, 0e m"sta+0a's reconstr"ct o"rp$'sio+o&ica+ s'nt$esis so asto see t$e 3oint action of a++ t$eparts 0e $a%e iso+ate# 4
-
8/12/2019 7147621 Human Physiology
6/41
PHYSIOLOGY an# LIF/
P$'sio+o&' #ea+s 0it$ t$ef"nctions of +i%in& t$in&s t$"s
it #ea+s 0it$ +ife itse+f Life is t$e interp+a' of t$eor&anism to its en%ironment
It e p+ains t$e p$'sica+ an#c$emica+ factors t$at areresponsi*+e for t$e ori&in,
#e%e+opment an# pro&ression of
-
8/12/2019 7147621 Human Physiology
7/41
A!!5IBU!/S OF !H/ HUMANBODY
1 Or&ani6ation( Irrita*i+it'
.ontracti+it'7 N"trition8 5espiration9 / cretion: Meta*o+ism an# Gro0t$;
5epro#"ction
-
8/12/2019 7147621 Human Physiology
8/41
HUMAN BODY
1 So+i# component.e++
!iss"es - master tiss"es- %e&etati%e tiss"es
Or&ans
S'stems( Li)"i# component
( Ma3or f+"i# compartments
-
8/12/2019 7147621 Human Physiology
9/41
FLUID .OMPA5!M/N!S
Interna+/n%ironment
P+asma < LISF < 11L
(= of !BF1= of !BF
(;LVolume17LPO 7 - Anions.+ -
> ? , M&??CationsNa ? , .a ??@; mOsm=LOsmolarit
y @; mOsm=L
: 8-: 7 pH: 7-: 78
I.F/.F
-
8/12/2019 7147621 Human Physiology
10/41
HOM/OS!ASIS
!$e maintenance of t$e *o#'in a stse of re+ati%e constanc'
in t$e interna+ en%ironmentCONTROL SYSTEM < 0or s on
1 .e++"+ar +e%e+( Or&anisma+ +e%e+
!$ro"&$o"t t$e entire *o#'
-
8/12/2019 7147621 Human Physiology
11/41
.HA5A.!/5IS!I.S
5ef+e in nat"reOperates on a fee#*acmec$anism, most+' - C rare+'
?Amp+ification or GainOsci++ation < #ri%in&, 0a in&,#ampe#
-
8/12/2019 7147621 Human Physiology
12/41
./LL an# its FUN.!IONS
.e++s, +i e t$e $"man *o#'$as
1 Di%ision of +a*or( Specia+i6ation
M"t"a+ interaction7 .entra+i6e# contro+
.e++ < *asic +i%in& "nit of t$e
*o#'
-
8/12/2019 7147621 Human Physiology
13/41
P5O!OPLASM
!$e #ifferent s"*stances t$atma e "p t$e ce++ It is
compose# of ( ater
/+ectro+'tes7 Proteins8 Lipi#s9 .ar*o$'#rates
< principa+ f+"i# me#i"m
- Ma3or cations an#anions- Ne t to 0ater, most
a*"n#ant
- ( t'pesa Str"ct"ra+
-P$osp$o+ipi#s an# c$o+estero+
- !ri&+'ceri#es an# nat"ra+ fats- Litt+e str"ct"ra+
f"nction
-
8/12/2019 7147621 Human Physiology
14/41
PHYSI.AL S!5U.!U5/ of t$e./LL
.ontains $i&$+' or&ani6e#p$'sica+ str"ct"res ca++e#Or&ane++es
.o%ere# 0it$ a mem*rane
are t$e n"c+e"s, en#op+asmicretic"+"m, mitoc$on#ria,+'sosomes, an# Go+&i
apparat"s
-
8/12/2019 7147621 Human Physiology
15/41
./LL M/MB5AN/
It en%e+opes t$e ce++It is compose# most+' of
Proteins < 88ELipi#s < 7(EP$osp$o+ipi#s < (8E.$o+estero+ < 1 EOt$er Lipi#s < 7E
.ar*o$'#rates < E
-
8/12/2019 7147621 Human Physiology
16/41
./LL M/MB5AN/1 Lipi# Mem*rane
- Basic str"ct"re is a *i+a'er* P$osp$o+ipi# part
1 H'#rop$i+ic part- ater so+"*+e- .onsists of t$e $ea# &ro"p
- P$osp$ate portion( H'#rop$o*ic part
- Fat so+"*+e- .onsists of t$e ( c$ain &ro"p- Fatt' ac'+ portion
-
8/12/2019 7147621 Human Physiology
17/41
./LL M/MB5AN/
P$osp$o+ipi# Bi+a'erPrimari+' responsi*+e for t$epassi%e permea*i+it' propertiesof t$e mem*rane.$o+ine containin&
+ecit$in p$osp$ati#'+c$o+ineSp$in&om'e+in
Aminop$osp$o+ipi#sP$osp$ati#'+serineP$osp$ati#'+et$ano+amine
-
8/12/2019 7147621 Human Physiology
18/41
./LL M/MB5AN/
Ot$ersP$osp$ati#'+&+'cero+
P$osp$ati#'+inosito+car#io+ipin
.$o+estero+
G+'co+ipi#s
-
8/12/2019 7147621 Human Physiology
19/41
LIPID BILAY/5
Feat"resIt is f+"i# an# not so+i# so portions oft$e mem*rane can f+o0 +itera++' from
one point to anot$erS"*stances #isso+%e# or f+oatin& in t$e+ipi# *i+a'er #iff"se to a++ areas of t$ece++ mem*raneLipi# so+"*+e s"*stances easi+' crosst$e +ipi# *i+a'er
ater so+"*+e s"*stances #o not#isso+%e in t$e +ipi# *i+a'erC t$e' crosst$e mem*rane t$ro"&$ 0ater-fi++e#c$anne+s, pores, or carriers
-
8/12/2019 7147621 Human Physiology
20/41
( M/MB5AN/ P5O!/INS
Most+' G+'coproteinsFi*ronectin < inte&rins
( t'pes of Proteins( Inte&ra+ proteins
Perip$era+ proteins
-
8/12/2019 7147621 Human Physiology
21/41
M/MB5AN/ P5O!/INS
F"nctions( Anc$or
P"mps7 .arriers8 Ion c$anne+s9 5eceptors: /n6'mes; Anti*o#' processin&
-
8/12/2019 7147621 Human Physiology
22/41
M/MB5AN/.A5BOHYD5A!/S
!$e' are referre# to as t$e ce++G+'coca+'
In com*ination 0it$ +ipi#s