7. heart pathology; myocadial diseases

Heart -PathologyHeart -PathologyMyocardial diseases

Cardiomypathies Types Dilated (DCM), Hypertrophic (HCM), Restrictive (RCM)

Myocardial diseasesCardiomypathies

Types Dilated (DCM), Hypertrophic (HCM), Restrictive (RCM)

Feature DCM HCM RCM

Cause Idiopathic in most ( 1/3 –Genetic), alcohol, viral, vit. B1 deficiency

Genetic mutations in myocyte proteins in All cases ( MC-beta myosin chain mutations)

Rx related ( radiation) and infiltrative disorders ( amyloidosis, Metastasis, storage diseases, Sarcoidosis)

Dysfunction Systolic Diastolic Diastolic

Ejection fraction (normal 60%)

<25% - -

Chambers enlarged

All four Lt. atrium Both atria

Dr. Krishna Tadepalli, MD, www.mletips.com

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CARDIOMYOPATHYCARDIOMYOPATHYDilated Cardiomyopathy – Mural thrombi Globoid shape ( inferior part of heart rounded shape ) Hypertrophy < dilatation ( increased, normal, or decreased thickness)

Restrict ive Cardiomyopathyventricle walls stif f (not

di lated)Both atria are dilated

Impaired diastolic f i l l ing

Hypertrophic Cardiomyopathy –Massive hypertrophy in septum and free wall of ventricleImpaired diastolic fi l l ing Dilation of atrium


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Heart -PathologyHeart -Pathology

Myocardial diseases Dilated (DCM) globoid heart

Hypertrophic (HCM) hypertrophic inter ventricular septum (3 times thicker than left ventricular wall -3:1), banana shaped septum Myocyte disarray, fibrosis What is normal septal to ventricular wall thickness ratio?

Myocardial diseases Dilated (DCM) globoid heart

Hypertrophic (HCM) hypertrophic inter ventricular septum (3 times thicker than left ventricular wall -3:1), banana shaped septum Myocyte disarray, fibrosis What is normal septal to ventricular wall thickness ratio?

Which Cardiomyopathy?


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Myocardial diseases Myocarditis Causes

viral ( MC in North America – Coxsackie B) Trypanosoma cruzi – (MC in South America) Hypersensitivity drugs Giant cell Idiopathic

Clinical nonspecific( Flu like – fever, Dyspnea), pain, palpitations

Types

Myocardial diseases Myocarditis Causes

viral ( MC in North America – Coxsackie B) Trypanosoma cruzi – (MC in South America) Hypersensitivity drugs Giant cell Idiopathic

Clinical nonspecific( Flu like – fever, Dyspnea), pain, palpitations

Types


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Myocarditis Types

Myocarditis Types

Feature Lymphocytic (Viral)

Chaga’s Giant cell Hyper-sensitivity

Cause Viral (Coxsackie B)

Trypanosoma Idiopathic Drugs ( antibiotics, anti –HTN)

Geography North America South America - -

Cell response Lymphocytes Necrosis +PMN +organisms

Giant cells, PMN,

Eosiophils

Prognosis - - Poor -


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Myocarditis - TypesMyocarditis - Types


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7. heart pathology; myocadial diseases

Health & Medicine

Transcript of 7. heart pathology; myocadial diseases