Combined approved technologies

Continuous Manufacturing

Prospekt Nr. 655

swiss made

Continuous Mixing and Granulation

The two Swiss companies Gerteis® and Gericke present the world’s

first solution for continuous tablet manufacturing. Therefore the

Gerteis® compacting and granulating technology is combined with

feeding and mixing solutions from Gericke. Both systems are fully

developed and have been proven in the market.

Approved systems for a reliable production

The most important challenge for the pharmaceutical industry is to

take the QbD concept and look at its manufacturing processes in

‘lean’ terms to start to adapt for a more efficient future. Gerteis® dry

granulation and Gericke continuous mixing process technologies are

ideally suited to the new era of efficient solid dose pharmaceutical

manufacturing.

Combining the continuous Gericke feeding and continuous mixing

and Gerteis® advanced dry granulation will enable consistent, cont-

rolled and stable granulated products to be manufactured. Using the

latest PAT techniques constant density can be achieved, leading to

consistent granule properties ideal for tableting and capsule filling

technologies.

ulation

Continuous Feeding and Mixing Technology

by Gericke

Process Control

Continuous metering and control of flow rates of API and Exciptients

Continuous metering of mixer content and mean mixing time

Chemical composition e.g. by on line NIR spectroscopy

Gericke continuous mixing systems have a capacity from 5kg/h to

500 kg/h and are used in the pharma industry for:

Precise and compact continuous feeding and mixing of API and

excipients

Minimising risk of segregation

Addition of lubricants

Wetting of mixtures upstream wet granulation or fluid bed granu-

lation

Mixing upstream roller compaction

Easy to Clean

Gericke feeders and mixers are designed for quick and easy cleaning.

All parts with product contact can be removed in short time for

cleaning.

y

Gericke continuo

500 kg/h and are

Precise and

excipients

Minimising r

Addition of

Continuous Roller Compaction & Dry Granulation

by Gerteis®

Gerteis® dry granulation technology is already a continuous technology

extensively proven. With the low energy compaction capability it minimises

high energy losses likely to generate control and process variability for

example caused by temperature variation.

Best suited for continuous manufacturing

Gerteis® advanced roller compaction technology has a number of control

parameters that are process critical and that are tightly controlled, defined

and stable. By calibrating this control functionality, a long-term stable,

consistent and a repeatable process can be achieved. There is also a signi-

ficant benefit to this tight repeatable control in terms of scale up and rapid

process stabilisation essential aspects of continuous manufacturing. This

also provides a much greater design space for process developers allowing

much improved capability with input raw material variability also providing

a wider compression window improving tableting speed, and tablet solubi-

lity for example by compressing at lower compression forces.

extensivel

high energ

example ca

Best suite

Gerteis® a

paramete

and stable

consistent

Product capacity

Mini-Pactor® for development, pilot plant, clinical and small scale production:

10 Grams up to 100 kg/h

Macro-Pactor® for development, pilot plant, clinical and full scale production:

100 Grams up to 400 kg/h

Area of applicationThe versatility of the machines from Gerteis

® and Gericke allows to

process virtually all kinds of powder, even the most difficult ones.

And with our ingenious machine design, the cleaning cycles are fast

and thorough, enabling you to switch between batches swiftly.

A wide range of applications are suitable for this advanced and effici-

ent technology combination. The overall efficiency gains in process

and true cost of ownership compared to other technologies offer an

interesting opportunity to reduce the cost per tablet, improve tablet

quality and substantially improve the pharmaceutical manufacturing

efficiency.

Pharmaceutics

Chemicals

Foods

Antibiotics

Lactose

Natrium bicarbonate

Ibuprofen

Paracetamol

Speciality Chemicals

Plastics

Colouring

Detergent powder

Vitamins

Aromas / Flavours

Minerals

Animal feeding

Spice extract

Instant blends

Gericke Feeding and Mixing Technologies

When space is at a premium, Gericke continuous mixing systems

offer the ideal solution. Gericke also provide full recipe management

programmes incorporating feeding and flow control for maximum

mixing consistency. When the process involves multiple components

and frequent product changes, Gericke batch mixing stations are

used.

About Gericke

Gericke supplies conveying, sifting, high-precision feeding and

mixing solutions that handle a broad range of ingredients such as

pellets, powders, floodable powders and fibreglass for food, chemi-

cal, industrial, and pharmaceutical industries.

Gericke was founded in 1894 and is managed by Markus Gericke in

the 4th generation.

Gerteis® your Dry Granulation Experts

Gerteis® is a Swiss manufacturer of advanced high quality roller com-

pactor dry granulators who have set the standard with their unique

dry granulation technology. Their understanding of the dry granulation

process combined with patented roller compaction systems make Ger-

teis® the unrivalled technology leader in the field of dry granulation.

About Gerteis®

With more than 25 years in business, Gerteis® Maschinen + Process-

engineering AG is dedicated to providing world leading technology

for dry powder granulation for the pharmaceutical and healthcare

industries. The company is privately owned and managed by Paul

Gerteis.

Gericke AG

Althardstrasse 120

8105 Regensdorf (Switzerland)

info@gericke.net

T +41 44 871 3636

F +41 44 871 36 00

www.gericke.net

Gerteis Maschinen + Processengineering AG

Stampfstrasse 74

Postfach 2247

8645 Jona SG (Switzerland)

sales@gerteis.com

T +41 55 222 55 22

F +41 55 222 55 23

www.gerteis.com