48 hr
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Supplemental Figure 6 R3Mab reduces serum levels of human pro- MMP-10 in mice bearing RT112 xenograft tumors in a dose- and time-dependent manner. Mice with pre-established RT112 tumors were grouped randomly into cohorts of 5 for treatment with either a control antibody (0) or R3Mab (3 or 30 mg/kg). Serum was collected at 48 hr or 96 hr post-treatment, and human pro-MMP-10 level was measured by Elisa. 48 hr 96 hr Pro-MMP-10 (ng/mL)
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Pro-MMP-10 (ng/mL). 48 hr. 96 hr. Supplemental Figure 6 R3Mab reduces serum levels of human pro-MMP-10 in mice bearing RT112 xenograft tumors in a dose- and time-dependent manner. - PowerPoint PPT Presentation
Transcript of 48 hr
Supplemental Figure 6 R3Mab reduces serum levels of human pro-MMP-10 in mice bearing RT112 xenograft tumors in a dose- and time-dependent manner. Mice with pre-established RT112 tumors were grouped randomly into cohorts of 5 for treatment with either a control antibody (0) or R3Mab (3 or 30 mg/kg). Serum was collected at 48 hr or 96 hr post-treatment, and human pro-MMP-10 level was measured by Elisa.
48 hr 96 hr
Pro
-MM
P-1
0 (
ng
/mL
)
Supplemental Figure 7 R3Mab reduces serum levels of human MMP-1 and pro-MMP-10 in mice bearing UMUC-14 xenograft tumors. Mice with pre-established UMUC-14 tumors were grouped randomly into cohorts of 10 and treated with a control antibody (Ctrl Ab) or R3Mab (30 mg/kg). Serum was collected at indicated time points, and subject to ELISA for total human MMP-1 (A) and pro-MMP-10 (B).
A
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