Agnogenic myeloid metaplasia

Links : http://emedicine.medscape.com/article/197954-overview

http://www.diseasesdatabase.com/links1.asp?glngUserChoice=8616

"A chronic myeloproliferative disorder characterized by bone

marrow fibrosis, proliferation of atypical megakaryocytes and

granulocytes in the bone marrow, anemia, splenomegaly,

and extramedullary hematopoiesis. The cause is unknown.

The median survival time is 3-5 years from diagnosis. (WHO,

2001)"

"A partial or complete replacement of the bone marrow

stroma by fibrous tissue. It can be a primary bone marrow

lesion as part of the chronic myeloproliferative disorders

(chronic idiopathic myelofibrosis), a manifestation of

acute myeloid leukemia (acute panmyelosis with

myelofibrosis), or a secondary phenomenon due to bone

marrow involvement by a metastatic tumor (e.g.,

metastatic breast carcinoma). --2003"