3D texture analysis for characterising the structure of cancellous bone Picture in the middle By:...
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Transcript of 3D texture analysis for characterising the structure of cancellous bone Picture in the middle By:...
3D texture analysis for characterising the structure of cancellous bone
Picture in the middle
By: Rafael AragonSupervisor: Murk Bottema
Project aim
• Find a method for quantifying textures to distinguish different health states of bone.
• Motivation– Monitor diseases– Prescribe medications– Life style choices– Discover underlying medical conditions
Biomedical side
• Bone health states– Living tissue– Remodels over time– Osteoblasts and Osteoclasts
• Related to hormones– Multiple hormones– Males and females affected
The rats
• Data was obtained from 30 Sprague-Dawley rats by micro CT scans.– Retrospective study– Scans were on the tibia bone.
• Scans taken on weeks 0, 2, 4, 8 and 12– Balance of data collection vs radiation exposure
The rats
• 30 rats in total– there were 3 different experimental groups. – 10 rats were ‘sham rats’– 10 rats were ‘ovx rats’ – 10 rats were ‘ovx + treament rats’
• Treatment started in week 2
Surgery and hormones
• Ovariectomy is the surgical removal of ovaries
• Low oestrogen is correlated to sparse bones
• ‘Ovx rats’ had their cancellous bone greatly reduced by the end of the experiment
What is cancellous bone?
• Cancellous bone is made up from trabeculae.– Cancellous bone is “spongy”. – Sparse compared to
cortical bone (dense)
• Micro CT of cancellousbone.
Biomedical to mathematics connection
• Textons– Characterise patterns– Can be compared
• Textons were introduced by Bela Julesz in 1981 – Primarily in vision research
Textons
• Textons can be used for image recognition.– Surveillance– Object recognition– Diagnosing medical conditions
• Specifically, textons will be used to screen medical conditions in rats by using the collected bone data
Textons and bone data
• Textons can be generated from the rat data– Local textures are in 3D– Feature space is generated– Finding the number of clusters– Finding how well the textons separate the 3
experimental groups–Characterise the structure of cancellous
bone according to the texture patterns