3D Printed Medicines: A Digital Pharmacy Era€¦ · 3D Printed Medicines: A Digital Pharmacy Era....
Transcript of 3D Printed Medicines: A Digital Pharmacy Era€¦ · 3D Printed Medicines: A Digital Pharmacy Era....
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3D Printed Medicines: A Digital Pharmacy Era
Sarah Trenfield, MPharmSenior Formulation Scientist, FabRx Ltd.
[email protected]@FabRx_3DP@SarahTrenfield1
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Evolution of TechnologyA Historical Perspective
2016 2017 2018
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1784
• Steam• Water• Mechanised Production
1st Industrial Revolution
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A Historical Perspective
2017 2018
You can simply impress your audience and add a unique zing and appeal to your Presentations. .
Your Text Here
You can simply impress your audience and add a unique zing and appeal to your Presentations. .
Your Text Here
Evolution of Technology
1784 1870
• Steam• Water• Mechanised Production
1st Industrial Revolution
• Division of Labour• Electrical Energy• Mass Production
2nd Industrial Revolution
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A Historical Perspective
Evolution of Technology
1784 1870 1969
• Steam• Water• Mechanised Production
1st Industrial Revolution
• Division of Labour• Electrical Energy• Mass Production
2nd Industrial Revolution
• Electronics• IT• Automated Production
3rd Industrial Revolution
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1784 1870 1969 Now
• Steam• Water• Mechanised Production
1st Industrial Revolution
• Division of Labour• Electrical Energy• Mass Production
2nd Industrial Revolution
• Electronics• IT• Automated Production
3rd Industrial Revolution
• IoT• Mass Customisation• 3D Printing
4th Industrial Revolution (?)
A Historical Perspective
Evolution of Technology
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Current 3D Printing Applications
Medical Applications
Tissue engineering
Dentistry
Medical devices & prosthetics 3D Printed Tablets
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Current 3D Printing Applications
Medical Applications
Tissue engineering
Dentistry
Medical devices & prosthetics 3D Printed Tablets
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The 3 Ds of 3D Printing Medicines
CAD software
Design Develop Dispense
Excipient selectionPrinting parameters
On-site printlet production and dispensing
Personalised Medicines
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A Need for Personalisation
Differences in:• Age• Gender• Ethnicity• Comorbidities• Body type• Polypharmacy
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Motivations for 3D Printing
1. Dose Flexibility
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1. Dose Flexibility
• Mass produced• Fixed strength
Conventional Manufacture
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1. Dose Flexibility3D Printing Medicines
• Variety of strengths
• Dosing accuracy
• Personalisation
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Motivations for 3D Printing
1. Dose Flexibility 2. DecentralisedProduction
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2. Decentralised Production
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Motivations for 3D Printing
1. Dose Flexibility 2. DecentralisedProduction
3. Patient Centered Design
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3. Patient Centered Design
Choice of:
• Shape• Size• Colour• Flavour• Formulation Type
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3. Patient Centered Design
Sphere
Torus
DiscTilte
d
Capsu
le0
20
40
60
80
100
Parti
cipa
nts
(%)
Shapes
5 4 3 2 1
Post-swallowing
Patient reported outcome (PRO)
Patient acceptability of 3D printed tablets
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Motivations for 3D Printing
1. Dose Flexibility 2. DecentralisedProduction
3. Patient Centered Design
4. Unique Dosage Forms
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4. Unique Dosage FormsPolypills
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4. Unique Dosage Forms
Personalised Polypills
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4. Unique Dosage Forms
Personalised Polypills
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4. Unique Dosage FormsFast-dissolving Printlets
• Immediate release
• Orally disintegrating in ~2 seconds
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Improved Patient Outcomes
Paediatrics and Geriatrics Complex Regimes
Tailored dosage forms
Reduced side effects Improved efficacy Improve medication adherence
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Our Vision… A Digital Pharmacy
Therapeutic Need
Digital Prescription
3D PrinterPersonalisation
Digital DesignAdministration
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FDA-Approved 3D Printed Tablet
Well-defined niche;High-dose (250, 500, 750 & 1000 mg)Oro-dispersible tablet
Spritam® (levetiracetam): Aprecia Pharmaceuticals
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Conclusion• 3DP could cause a paradigm shift in pharmaceuticals• Don’t judge the technology from the early manifestations
– We are required to come together!
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Thank you!