36 2 The Muscular Systemmgaughan-biology.weebly.com/.../1/0/3/110365537/ch_36_muscular_s… ·...
Transcript of 36 2 The Muscular Systemmgaughan-biology.weebly.com/.../1/0/3/110365537/ch_36_muscular_s… ·...
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36–2 The Muscular System
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Muscular System Functions
• Skeletal muscle
pulls on the bones of
the skeleton,
creating movement.
• Even when not
moving, skeletal
muscle is partially
contracted,
maintaining tone
and posture.
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• Circular muscles called
sphincters control openings
in the digestive and urinary
systems.
• A wall of skeletal muscle
provides protection for the
organs of the abdominal
cavity.
• Muscle contractions generate
heat, helping to maintain
body temperature.
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Muscles
The function of the muscular system is movement.
More than 40% of the mass of the average human
body is muscle.
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Types of Muscle Tissue
There are three different types of muscle
tissue:
• skeletal
• smooth
• cardiac
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Types of Muscle Tissue
Skeletal Muscles
Skeletal muscles:
• are usually attached to bones.
• are responsible for voluntary movements.
• are sometimes called striated muscles,
meaning they appear “striped”.
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Types of Muscle Tissue
Smooth Muscles
Smooth muscles:
• are usually not under voluntary control = involuntary.
• are spindle-shaped.
• are not striated.
• are found in many
internal organs and
blood vessels.
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Types of Muscle tissue
Most smooth muscle cells can function without
nervous stimulation.
They are connected by gap junctions that allow
electrical impulses to travel among muscle cells.
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Types of Muscle Tissue
Cardiac Muscle
Cardiac muscle:
• is only found in the heart.
• is striated.
• is involuntary.
• Cells are connected to each other by gap junctions.
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Anatomy of a Muscle
• Each muscle is covered with
epimysium, a layer of collagen
fibers that separates it from
surrounding organs.
• The muscle is made of bundles
called fascicles.
• Each fascicle is divided by another
layer called the perimysium.
• Nerves and blood vessels are also
found here.
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• The endomysium surrounds and each
individual muscle fiber (cell).
▫ Also contains nerves, capillaries, and stem cells
used to repair muscle.
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• At each end of the muscle, the
collagen fibers from all three layers
come together to form one of two
possible structures:
▫ A bundle of collagen fibers called a
tendon, which attaches the muscle
to a bone.
▫ A sheet of collagen fibers called an
aponeurosis, which attaches the
muscle to another muscle.
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Muscle Fibers (cells)
• Individual skeletal muscle cells are called muscle
fibers due to their length.
▫ Longest is in the sartorius muscle – 30cm!
• Each fiber is multinucleated in order to control
protein synthesis across the entire cell.
▫ This arrangement
makes them amitotic,
or unable to divide.
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• The sarcolemma, or cell membrane of the muscle fiber, is covered with openings to a network of small tubules called T tubules.
• A special type of smooth ER called the sarcoplasmic reticulum attaches to the T tubules and forms a network found in muscle cells. ▫ Stores calcium ions that are released during contraction.
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• Each muscle fiber contains myofibrils – Bundles of protein filaments within the muscle fiber.▫ Thin, light filaments, made of the protein actin▫ Thick, dark filaments, made of the protein myosin.
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Muscle Contraction
Muscle Contraction
The fibers in skeletal muscles are composed of
smaller structures called myofibrils.
Each myofibril has smaller structures called
filaments.
•Thick filaments = myosin.
•Thin filaments = actin.
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Copyright Pearson Prentice Hall
Muscle Contraction
Filaments are arranged along the muscle fiber in
units called sarcomeres.
Sarcomeres are separated by regions called Z
lines.
When a muscle is relaxed, there are no thin
filaments in the center of a sarcomere.
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Muscle Contraction
Skeletal muscles are made up of bundles of muscle fibers, which in turn are
composed of myofibrils. Each myofibril contains thin filaments made of actin
and thick filaments made of myosin. Muscle fibers are divided into functional
units called sarcomeres.
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Muscle Contraction
• Muscle contraction begins with a nerve signal
that is transmitted through the motor neuron.
• This signal is sent to every fiber in the muscle
simultaneously through the t-tubules.
• The sarcoplasmic reticulum releases calcium
ions (Ca2+), initiating muscle contraction.
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Muscle Contraction
• The calcium influx stimulates the myosin
filaments to form connections to the actin
filaments.
▫ The myosin filaments pull the actin filaments
inward, causing the muscle to contract.
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Muscle Contraction
• When a muscle contracts, it pulls bones closer
together, creating movement.
• Contracted muscles
become more visible
because all of the
volume (cytoplasm)
is forced outward,
creating a muscle
belly.
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• The amount of tension generated by a muscle
and its endurance are dependent on two factors:
▫ The amount of energy (ATP) available in the
muscle tissue.
▫ The amount of stimulation received by the muscle
from the nervous system.
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Muscle ContractionA muscle contracts when the thin filaments in the
muscle fiber slide over the thick filaments.This
process is called the sliding filament model of muscle
contraction.
During muscle contraction, the actin filaments slide
over the myosin filaments, decreasing the distance
between the Z lines making the muscle shorter:
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Copyright Pearson Prentice Hall
Muscle Contraction
Binding sites
Myosin
Cross-bridge
Actin
Movement of Actin Filament
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Muscle Contraction
During muscle contraction, the head of a myosin filament attaches to a binding site on actin, forming a cross-bridge.
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Muscle Contraction
Powered by ATP, the myosin cross-bridge changes shape and pulls the actin filament toward the center of the sarcomere.
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Muscle Contraction
The cross-bridge is broken, the myosin binds to another site on the actin filament, and the cycle begins again.
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Muscle Contraction
When many myosin cross-bridges change shape
in a fraction of a second, the muscle fiber shortens
with considerable force.
The energy for muscle contraction is supplied by
ATP.
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Control of Muscle Contraction
Control of Muscle Contraction
The energy for muscle contraction is supplied by ATP.
Impulses from motor neurons control the contraction of
skeletal muscle fibers.
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Control of muscle contraction
A neuromuscular junction is the point of contact
between a motor neuron and a skeletal muscle cell.
Vesicles in the axon terminals of the motor neuron
release a neurotransmitter called acetylcholine.
Acetylcholine produce an impulse in the cell
membrane of the muscle fiber.
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Control of muscle contraction
The impulse causes the release of calcium ions
within the fiber.
The calcium ions affect regulatory proteins that allow
actin and myosin filaments to interact.
A muscle cell remains contracted until the release of
acetylcholine stops and an enzyme produced at the
axon terminal destroys any remaining acetylcholine.
Then, the cell pumps calcium ions back into storage,
the cross-bridges stop forming, and contraction
ends.
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Muscle Stimulation
• A twitch is a single
stimulus-contraction
relaxation sequence in a
muscle.
• A twitch begins with a
stimulus, or signal by a
motor neuron.
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• During the latent
period, the signal is
spreading across the
muscle. No actual
tension occurs.
• In the contraction
phase, tension is
created.
• Myosin and actin
uncouple in the
relaxation phase, and
the tension decreases.
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Frog Muscle TwitchA frog muscles do not succumb to rigor mortis as
quickly as most warm-blooded animals which
makes it possible for the muscles to move post-
mortem if energy is applied to them some how.
This can be done either by cooking (heat/energy)
or by salting (ions).
Salt,also known as NaCl, can work like electricity
because it is made up of ions (Sodium and
Chlorine to be exact) and ions carry an electrical
charge. In living animals, sodium delivers a
signal to cause muscles to contract.
The frog legs in the video are fresh so energy
(ATP) is still stored in the cells. When the
electrical impulse is applied, the legs contract
even though the frog is dead!
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Summation• A single twitch is short
(milliseconds) and doesn’t really produce a useful movement.
• If a second stimulus arrives before the relaxation phase completes, a more powerful contraction occurs. This is summation.
• When enough summation occurs, a powerful, prolonged contraction called tetanusoccurs.
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Case Study: Rigor Mortis
• When an organism dies, calcium ions will leak out of the
sarcoplasmic reticulum, causing one last sustained
muscle contraction.
▫ Because no ATP is left in the muscle, the myosin and
actin are unable to separate, causing rigor mortis.
• As the cells of the body die, enzymes are released from
the lysosomes.
• These enzymes break down the actin and myosin
filaments, and the muscles permanently go limp.
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Energy for Muscle Contraction
• ATP is the direct unit of energy used by muscle fibers. If the supply of ATP is exhausted, the muscle becomes fatigued and will not contract.▫ ATP is converted to ADP when it is used.
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• ATP is generated by two metabolic processes in
cells.
• Glycolysis produces 2 molecules of ATP for
every 1 molecule of glucose.
▫ Anaerobic, meaning no oxygen is used.
▫ Takes place in the cytoplasm.
• Cell respiration produces 34 molecules of ATP
for every 1 molecule of glucose.
▫ Aerobic, meaning oxygen is required.
▫ Takes place in the mitochondria.
▫ Releases carbon dioxide, which we exhale.
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Energy Storage in Muscles
• While at rest, skeletal muscle fibers produce
more ATP than they need.
▫ ATP is an unstable molecule, so it has to be stored.
• Muscles can store energy in two forms:
▫ Creatine Phosphate
▫ Glycogen
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• ATP can be used to convert creatine into creatine phosphate...
Creatine + ATP → Creatine-Phosphate
…which can then regenerate ATP when needed.
Creatine-phosphate + ADP → ATP + Creatine
• Creatine phosphate is very short-term storage, and is used up in about 15 seconds of activity.
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• Muscle cells can
also produce
glycogen, a
polysaccharide
made of thousands
of glucose
molecules.
▫ Glucose + ATP
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• The generation of creatine-phosphate and
glycogen are considered anabolic reactions,
because ATP is used to build large molecules.
• Catabolic reactions break down larger
molecules into smaller ones, releasing energy as
ATP.
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• While at rest, the muscle fiber is performing anabolic reactions:▫ Creatine → Creatine Phosphate
▫ Glucose → Glycogen
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• During moderate activity, the muscle fiber switches to catabolic reactions:▫ Glycogen → Lots of Glucose
▫ Glucose + O2 → CO2 + H2O + ATP
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• Fatigue occurs during activity when muscle
fibers are deficient in one or more of the
ingredients needed in catabolic reactions.
▫ If glycogen runs out,
this is called hitting the wall.
▫ If oxygen levels are
insufficient, you are
out of breath.
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Lactic Acid Formation
• When oxygen levels are low, muscle fibers
attempt to compensate by relying more on
anaerobic glycolysis.
▫ This produces less ATP (2 instead of 34 ATP) and
creates a waste product called lactic acid.
• Lactic acid can cause fatigue and soreness.
▫ It is gradually re-absorbed when oxygen levels
return to normal.
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Types of Muscle Fibers
• Fast-twitch fibers are able to reach peak
tension within 0.01 seconds or less of neural
stimulation.
▫ Large in diameter.
▫ Densely packed with myofibrils (actin and
myosin).
▫ Large glycogen reserves.
▫ Fewer mitochondria.
• Fast-twitch fibers produce the most tension, but
get fatigued quickly.
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• Slow-twitch fibers can take three times as long
to reach peak tension.
▫ Half the diameter of fast-twitch fibers.
▫ Increased network of capillaries, allowing for a
greater and more reliable oxygen supply.
▫ Contain a special protein called myoglobin that
reserves additional oxygen within the muscle.
▫ Higher numbers of mitochondria.
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• Chicken breasts are “white meat” because they have mostly fast-twitch fibers and less myoglobin.
▫ Wings are only used for short intervals to escape predators.
• The legs and thighs are “dark meat” and have mostly slow-twitch fibers and more myoglobin.
▫ Used much more frequently during the day, but not at the same intensity.
• Most human muscle is a mixture of fiber types, appearing pink.
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50
How Muscles and Bones Interact
How Muscles and Bones Interact
Skeletal muscles are joined to bones by tendons.
Tendons pull on the bones so they work like
levers.
The joint functions as a fulcrum.
The muscles provide the force to move the lever.
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How Muscles and Bones Interact
Opposing Muscles Contract and Relax
By contracting and relaxing, the triceps
and biceps in the upper arm enable you to
bend or straighten your elbow. A
controlled movement requires contraction
by both muscles.
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52
How Muscles and Bones Interact
Opposing Muscles Contract and Relax
By contracting and relaxing, the triceps and
biceps in the upper arm enable you to bend
or straighten your elbow. A controlled
movement requires contraction by both
muscles.
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Physical Conditioning• Physical conditioning can focus on improving muscle force
or endurance. Regular exercise is important in maintaining
muscular strength and flexibility
• Aerobic exercise focuses on improving endurance by
improving oxygen intake and increasing glycogen storage.
They help the body’s systems to become more efficient
▫ Jogging, distance swimming, etc.
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Physical Conditioning
• Anaerobic exercise focuses on improving strength
through hypertrophy. Aka resistance training
▫ The number of muscle fibers does not change, but
their size can. This is called hypertrophy.
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Anabolic Steroids• Anabolic steroids are chemical
compounds that mimic the effects of testosterone.▫ This increases protein synthesis in
muscle fibers.• As a hormone, testosterone
affects many other tissues besides muscles, causing side effects:▫ Increase in blood cholesterol.▫ Acne▫ High blood pressure▫ Testicular atrophy▫ Increase in male characteristics in
women.
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Muscular System Disorders
• Polio is a viral
infection that can
infects and destroys
motor neurons,
causing paralysis.
▫ Considered
eradicated due to a
vaccine.
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ALS (Lou Gehrig’s Disease)
• Amyotrophic Lateral
Sclerosis (ALS), also
known as Lou Gehrig’s
Disease, is a
neurodegenerative
disease that damages
motor neurons, resulting
in muscle atrophy due to
disuse.
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Muscular Dystrophy
• Muscular dystrophy
is a group of genetic
degenerative
disorders that cause
muscle atrophy.
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Muscle Anatomy
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Muscle Attachment
• All muscles are attached to at
least two points:
▫ The origin is an attachment to
a immoveable bone.
▫ The insertion is an
attachment to an movable
bone.
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Types of Muscle Movement• Flexion▫ Most often found in hinge joints.
▫ Brings two bones closer together.
• Extension▫ Opposite movement of
flexion.▫ Pulls two bones farther
apart.• Hyperflexion or
hyperextension▫ Flexion beyond the
normal position.
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Types of Muscle Movement
• Abduction
▫ Pulls a limb away from
the midline of the body.
• Adduction
▫ Pulls a limb toward the
midline of the body.
• Circumduction
▫ Rotation of a limb.
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Types of Muscle Movement
• Rotation is the
movement of a bone
in a circular direction
around a central axis.
• Medial rotation is
toward the midline.
• Lateral rotation is
away from the
midline.
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• Some muscles are
named based on the
direction of their fibers.
• Rectus means straight.
▫ Rectus abdominis.
• Oblique means
diagonally arranged.
▫ External abdominal
oblique.
How Are Muscles Named?
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• Muscles within a
group may have
different names
based on their size.
• Maximus and
longus indicates a
larger muscle.
▫ Fibularis longus
• Minimus and
brevis indicate a
smaller muscle.
▫ Fibularis brevis
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• Prefixes like bi- and tri- may be used to indicate multiple heads or attachment sites. ▫ Triceps brachii
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• Muscles may also be named based on their
origin and insertion bones.
▫ Sternocleidomastoid: sternum, clavicle, mastoid
process of the temporal bone
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• If a muscle resembles a shape, it can be named
after that shape.
▫ The deltoid is named after the Greek letter Delta,
which is a triangle.
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• Finally, muscle
names may indicate
a specific action
they perform.
▫ Flexor carpi ulnaris
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Head and Neck Muscles• The frontalis raises the eyebrows.
• The masseter and temporalis both elevate the mandible.
▫ Chewing muscles
• The buccinator flattens the cheeks during chewing, holding
them against the teeth.
• The orbicularis oculi performs all eyelid movements, including
opening, closing, blinking, etc.
• The orbicularis oris closes the mouth with the lips.
• The zygomaticus raises the corners of the mouth when
smiling.
• The sternocleidomastoid rotates the head and flexes the
neck.
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Muscles of the Trunk
• The pectoralis major adducts the humerus.
• The rectus abdominis flexes the vertebral
column and compresses the contents of the
abdomen.
▫ The “pushing” muscle of defecation, childbirth, and
forced breathing.
▫ The transversus abdominis also performs this
action.
• The external and internal obliques rotate the
trunk.
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Muscles of the Dorsal
Trunk
• The trapezius elevates and depresses the
scapula.
• The latissimus dorsi adducts the humerus.
• The deltoid abducts the arm.
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Anterior Muscles of the Arm
• The biceps brachii and brachioradialis flex the
arm.
• The triceps brachii extends the arm.
• The extensor carpi radialis and ulnaris extend
the wrist.
• The extensor digitorum extends the four non-
thumb digits.
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Posterior
Muscles
of the
Leg
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Anterior
Muscles
of the
Leg
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Muscles of the Hip, Thigh, and Leg
• The gluteus maximus adducts and extends the
leg.
• The gluteus medius abducts the leg.
• The hamstring group flexes the knee.
▫ Biceps femoris
▫ Semitendinosus
▫ Semimembranosus
• The gastrocnemius and soleus extend the
foot.
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Muscles of the Hip, Thigh, and Leg
• The sartorius flexes, abducts, and laterally
rotates the thigh.
▫ Look at the bottom of your foot while standing to
demonstrate these actions.
• The quadriceps group extends the knee.
▫ Rectus femoris
▫ Vastus medialis
▫ Vastus lateralis
▫ Vastus intermedialis (a deep muscle)
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Muscles of the Hip, Thigh, and Leg
• The tibialis anterior and fibularis muscles flex
the foot.
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