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Transcript of 346 Organic Chemistry Laboratory Fall 2013. CHEM 346 Lecture... · 346 Organic Chemistry Laboratory...
![Page 1: 346 Organic Chemistry Laboratory Fall 2013. CHEM 346 Lecture... · 346 Organic Chemistry Laboratory Fall 2013 ... Total synthesis of a sulfa-antibiotic! ... - 3 lab reports written](https://reader031.fdocuments.us/reader031/viewer/2022020412/5b0a005e7f8b9aba628b7c13/html5/thumbnails/1.jpg)
Lecture 1 Introduction to CHEM 346 September 3rd 2013
346 Organic Chemistry Laboratory Fall 2013
“The Undivided Mind” Imaginary Foundation, 2010
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READY FOR RESEARCH
Blackwell et al, J. Chem. Educ. 2006, 83, 1835-1843
UNDERGRADUATE CHEM 344
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What is CHEM 346?
- chemical information resources
Part 1 - Learning
- intermediate/advanced lab techniques
- scientific writing
- ethics in scientific research
- new organic chemistry
![Page 4: 346 Organic Chemistry Laboratory Fall 2013. CHEM 346 Lecture... · 346 Organic Chemistry Laboratory Fall 2013 ... Total synthesis of a sulfa-antibiotic! ... - 3 lab reports written](https://reader031.fdocuments.us/reader031/viewer/2022020412/5b0a005e7f8b9aba628b7c13/html5/thumbnails/4.jpg)
New organic chemistry & techniques
- 3 “scripted” lab projects
1. Total synthesis of a sulfa-antibiotic - protecting groups - EAS - antibacterial testing
NH2SO
OH2N
Sulfanilamide
What is CHEM 346?
Gerhard Domagk
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What is CHEM 346?
New organic chemistry & techniques
- 3 “scripted” lab projects
2. Visible light photocatalysis - ligand synthesis/coordination chemistry - photocatalysis of a Diels-Alder reaction - screening reaction conditions - collating & discussing experimental data
Ru
N
N
NN
N
N
NN
NN
NN
[Ru(bpz)3]2+
2+
R1
R2 R3R2
R1
R4R3
R4+
Diels-Alder
[Ru(bpz)3]2+
Prof. Tehshik Yoon UW-Madison
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What is CHEM 346?
New organic chemistry & techniques
- 3 “scripted” lab projects
3. Jacobsen epoxidation - ligand synthesis/coordination chemistry - asymmetric epoxidation of an alkene - mechanistic details
R1
R2
R1
R2O
Jacobsen catalyst
NaOCl
N N
O OMn
Jacobsen catalyst
Cl
Prof. Eric Jacobsen Harvard University
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What is CHEM 346?
Chemical information resources
- 2 sessions with chemistry librarian
Scientific writing
Ethics in scientific research
- overview and case studies
- peer review of first draft comments graded final draft
- 3 lab reports written in Organic Letters template
![Page 8: 346 Organic Chemistry Laboratory Fall 2013. CHEM 346 Lecture... · 346 Organic Chemistry Laboratory Fall 2013 ... Total synthesis of a sulfa-antibiotic! ... - 3 lab reports written](https://reader031.fdocuments.us/reader031/viewer/2022020412/5b0a005e7f8b9aba628b7c13/html5/thumbnails/8.jpg)
What is CHEM 346?
- chemical information resources
Part 1 - Learning
- intermediate/advanced lab techniques
- scientific writing
- ethics in scientific research
- new organic chemistry
Part II - Applying
- research project/lab placement
- poster presentation
![Page 9: 346 Organic Chemistry Laboratory Fall 2013. CHEM 346 Lecture... · 346 Organic Chemistry Laboratory Fall 2013 ... Total synthesis of a sulfa-antibiotic! ... - 3 lab reports written](https://reader031.fdocuments.us/reader031/viewer/2022020412/5b0a005e7f8b9aba628b7c13/html5/thumbnails/9.jpg)
This week
- processing/work-up of NMR data (Kaz)
Today
- training on NMR instrument (Dr. Fry)
- lab drawer check-in B341
Thursday
- begin sulfanilamide lab project
- read lab manual, know what you are doing