8/12/2019 305] 2013 Karatzi - Sesame Oil Consumption Exerts Beneficial Effect Endothelial Function Hypertensive Men

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Sesame oil consumption exerts a beneficial

effect on endothelial function in hypertensive

men

Kalliopi Karatzi1

Kimon Stamatelopoulos2

Maritta Lykka2

Pigi Mantzouratou1

Sofia Skalidi2

Nikolaos Zakopoulos2

hristos Papamichael2

Labros S Sidossis1!3

1Laboratory of Nutrition and Clinical Dietetics, Department of Nutrition and

Dietetics, Harokopio University, Atens, !reece2"ascular Laboratory, Department of Clinical #erapeutics, Ale$andra

University Hospital, Atens, !reece3Department of %nternal &edicine'!eriatrics, (ealy Center on A)in), %nstitute

for #ranslational (ciences and (riners *urns %nstitute, University of #e$as

&edical *ranc at !alveston, #e$as, U(A

Labros ( (idossis, Department of %nternal &edicine'!eriatrics, (ealy Center on A)in),

%nstitute for #ranslational (ciences and (riners *urns %nstitute, University of #e$as

&edical *ranc at !alveston, +ebecca (ealy Hospital *ld) -12., !alveston, #e$as,

//000'1//, U(A mail lasidoss4utmbedu

"bstract

#ackground$ #e aim of te study 5as to investi)ate te effects of sesame oil on

endotelial function and to detect te underlyin) mecanisms, bot in te postprandial

state and after lon)'term consumption

%esign$6e enrolled 3 ypertensive men in a t5o'pase study %n te first pase, 2-

volunteers consumed 307) of eiter sesame oil or control oil ndotelial function,

inflammatory activation and nitric o$ide syntase 8N9(: inibition 5as assessed after a

12'our fast and 2 ours after consumption of an oil'containin) standardi;ed meal %n

te second pase, 3 volunteers consumed 307) of sesame oil or control oil daily for 2

monts and te above'mentioned parameters 5ere assessed at baseline, 10, 3 and

- days

Methods$ ndotelial function 5as estimated by endotelium'dependent