3-D Multi-Species Biofilm Models
description
Transcript of 3-D Multi-Species Biofilm Models
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3-D Multi-Species Biofilm Models
F. Gao, X. Zhong, H. La, S. Krone, L. Forney
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Model based on nutrient diffusion and energy allocation
(1)
(2) (3)
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nutrient diffusion
Nutrient concentration in bulk liquid is set to be constant and normalized to 1.0;
Nutrient diffuses vertically through biofilm, from top down;
A site obtain nutrients diffusing from a cone-shaped region above the site
a site
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Birth rate
Allows multiple nutrients Metabolism Effects of environment on growth rate
Nutrient Energy
1
2
3
Maintenance
Stress response
Growth
ATPConversioncoefficient
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Placement of offspring Growth is suppressed if all
neighboring sites are occupied
Daughter cell placed at vacant direct neighbor chosen at random
If no direct neighbors available, 2nd direct neighbors considered
6 direct nbrs 26 2nd direct nbrs
6 direct nbrs 26 2nd direct nbrs
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Death rate
Death rate increased if a cell fails to get enough energy for maintenance and stress response
Death rate is proportional to the gap between the energy demand & actual energy available
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Collapse
Maximum thickness
Self regulationafterbefore
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simulations
3 species: 2 aerobic and 1 anaerobic
2 aerobic species
2 species: 1 aerobic and 1 anaerobic
randomly initialized