28th Annual Scientific Congress of the Hong Kong College ...
Transcript of 28th Annual Scientific Congress of the Hong Kong College ...
![Page 1: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/1.jpg)
Interesting Cases
Sharing and Discussion - the cardiologist's perspective
Dr Julia Shi Resident Specialist
Department of Paediatric Cardiology Queen Mary Hospital
28th Annual Scientific Congress of the Hong Kong College of Cardiology
![Page 2: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/2.jpg)
TSY, F/18y Referred for management of heart failure in Oct 2012
![Page 3: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/3.jpg)
History of AML July 2003 (13 months old) • Myelomonocytic AML diagnosed in July 2003 (13 months old) • UK AML chemotherapy protocol (Hospital A) • Pre-chemo echo: normal, FS 27.4%, LVIDd 2.65cm • Cardiotoxic medications received:
o Daunorubicin o Amsacrine o Mitozantrine
• Equivalent doxorubicin 260mg/m2
• In clinical remission since November 2003 (almost 9 years) • Otherwise good past health, no family history of cardiomyopathy
AML 2003 NYHA IV 2012 NYHA III → I-II 2013-now
![Page 4: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/4.jpg)
Decompensated Heart Failure Sep 2012 (10 years old)
• Admitted to Hospital B (Regional hospital) o Vomiting and diarrhoea x 2 days
o On & off abdominal pain x 1 month
o Decrease appetite
o Puffiness of eyelids
o Displaced cardiac apex
o Gallop rhythm, 2/6 PSM at apex radiating to axilla
o Hepatomegaly
• CXR – CT ratio 0.65
AML 2003 NYHA IV 2012 NYHA III → I-II 2013-now
![Page 5: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/5.jpg)
![Page 6: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/6.jpg)
Investigations for Cause of HF • Slight Troponin I (0.16ng/ml)
(normal up to 0.04ng/ml)
• Normal CK
• Echo : LVEF 30%, moderate MR
∆ ? Acute myocarditis
∆? Chronic heart disease with decompensation
![Page 7: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/7.jpg)
Initial Management • Inotropes : Dobutamine (10mcg/kg/min) & Milrinone
(1mcg/kg/min)
• Captopril, diuretics
• Transferred to Hospital A PICU after 12 days
![Page 8: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/8.jpg)
Initial Management Hospital A
• Viral study –ve, metabolic screening –ve
• Tn I 0.2-0.3 ng/ml
• Echo : LVEF 36% , severe MR
• Developed hypotension, nausea and vomiting upon weaning of inotropes
Could not wean off inotrope
Transferred to us after 4 weeks
![Page 9: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/9.jpg)
Further Investigations • Echo : dilated LV (LVIDd 5.2cm)
LVEF ~ 24%, pericardial effusion 4-6mm
• Borderline BP
![Page 10: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/10.jpg)
Cardiac catheterization
![Page 11: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/11.jpg)
• Endomyocardial biopsy
Interstitial fibrosis, cytoplasmic clearing suggestive of myofibrillar loss ,vacuolated cells No significant lymphocytic infiltration
EM : Nonspecific changes
Courtesy of Dr. WH Shek
![Page 12: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/12.jpg)
Diagnosis • No feature of myocarditis
• Although nonspecific, features can be seen in anthracycline cardiotoxicity
∆ Late-onset anthracycline cardiomyopathy
![Page 13: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/13.jpg)
Treatment • Levosimendan infusion x 24 hours
• Gradually weaned off inotropic infusions
• Discharged 2 weeks after admission
• Medications : Enalapril, Carvedilol, Digoxin, Frusemide, Spironolactone
![Page 14: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/14.jpg)
• Functional class I-II on last follow-up
• Can join PE lesson, slowly walk up 5FOS
Date LVIDd (cm) LVEF % MR
18/4/2013 4.3 45 Mild to mod
26/3/2015 4.4 52 Mild
27/12/2018 4.3 54 No
8/8/2019 4.3 56-60 Trace
AML 2003 NYHA IV 2012 NYHA III → I-II 2013-now
![Page 15: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/15.jpg)
CXRs
Oct 2012 Aug 2019
![Page 16: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/16.jpg)
Summary • Late-onset anthracycline-induced dilated cardiomyopathy
• Favorable response to medications
• Functional class IV → I-II
• LV reverse remodeling
![Page 17: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/17.jpg)
WCH, 13y/M Referred from Macau for post-chemotherapy dilated cardiomyopathy in
Jan 2014
![Page 18: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/18.jpg)
History of AML . Post-chemo DCM • Known AML post chemotherapy complicated with dilated
cardiomyopathy
• On multiple antifailure treatment for 10 years (since 2004) o Digoxin
o Captopril
o Carvedilol
o Diuretics
• AML in remission, no oncology FU now
![Page 19: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/19.jpg)
Complicated with Stroke • Severe headache and left sided hemiplegia including left facial
palsy in Jan 2014, admitted to hospital in Macau
• MRI brain showed ischemia change in Rt basal ganglion region
• Intensive physiotherapy was given with neurological improvement, regained almost full limb power
• Aspirin was started
![Page 20: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/20.jpg)
Clinically Worsened HF Functional class I-II → III
Physical Findings on admission to our unit
• Displaced apex
• Hepatomegaly 4cm
• Left facial palsy - UMN lesion, other CNs NAD
• Left upper and lower limbs – hyperreflexia, power 5-/5
![Page 21: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/21.jpg)
Investigations • Echo:
o Systolic dysfunction: LVEF 30-35%
o Features of diastolic dysfunction, MV E/A 3.0, E/e’ 7.1
• Holter: frequent premature ventricular beats, up to 11% of total, no runs of ventricular tachycardia
![Page 22: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/22.jpg)
Initial Management • Inotropic infusion: Dopamine 5mcg/kg/min
• Levosimendan x 48 hours
• Optimized carvedilol, digoxin, enalapril and diuretics doses
• Ventricular ectopics controlled with amiodarone
• Weaned off dobutamine after 2 days
• Discharged after 2 weeks
• Echo upon discharge: LVEF ~43%
![Page 23: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/23.jpg)
Follow-up Echo Nov 2015 • Dilated left atrium • Mildly dilated left ventricle, LVIDd 4.3cm • Mildly impaired LV and RV systolic function, LVEF~50%, TAPSE 16mm • Evidence of diastolic dysfunction, mitral E/A 2.6, E/e' 13 • Evidence of pulmonary hypertension, TR gradient 67 mmHg
![Page 24: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/24.jpg)
Cardiac Catheterization LV Function LVEF 45.5%
LVEDp 26-30mmHg
RV function Impaired systolic motion RVEDp 13-14mmHg RVSWI 667mmHg/mL/m2
CI 1.8L/min/m2
PASP 70-75% systemic
mPAP 45-48mmHg
PVR/PVRI 7.8-10/ 10.6-13.7
*Unable to tolerate nitroprusside test due to hypotension
![Page 25: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/25.jpg)
Outcome • Added Sildenafil and Bosentan
• Clinically progressive heart failure symptoms, NYHA class III-IV, SBP lowish at 90-100mmHg
• Received transplantation in mainland China (details unclear), and passed away during early post-operative period
![Page 26: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/26.jpg)
Summary • Post-chemotherapy cardiomyopathy with prominent diastolic
dysfunction
• Poor outcome with progression to pulmonary hypertension
• May require heart or heart-lung transplantation for refractory cases
![Page 27: 28th Annual Scientific Congress of the Hong Kong College ...](https://reader036.fdocuments.us/reader036/viewer/2022081421/62a1b9366e7872154a315768/html5/thumbnails/27.jpg)
Interesting Cases
Sharing and Discussion - chemotherapy-induced cardiomyopathy
Dr Julia Shi Resident Specialist
Department of Paediatric Cardiology Queen Mary Hospital
28th Annual Scientific Congress of the Hong Kong College of Cardiology