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    I. Dementia (Definition,

    Symptoms, Causes, Types,

    Prognosis, Treatment)

    II. Music Therapy (Treatment

    for Dementia Symptoms)

    III.Musicians Brain as a

    Model of Neuroplasticity

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    What is Dementia?de (apart) + mentis (mind)

    - a syndrome or a collection of symptoms

    caused by disease of the brain, usually of a

    chronic or progressive nature, in which

    there is disturbance of multiple higher

    cortical functions including memory,

    thinking, orientation, comprehension,

    calculation, learning capacity, language,

    and judgment.

    There is also loss of emotional control and

    experience agitation, delusions, and

    hallucinations.

    These impaired mental and emotionalfunctioning interferes everyday activities

    and social relationships.

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    What are the signs?

    Memory loss

    Moodiness

    Communicative difficulties

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    Death of nerve cells or loss ofcommunication among the cells

    No specific finding about how

    dementia develops

    Abnormal structures in the brain

    called inclusions (Alzheimer's

    disease, Lewy body dementia,Parkinson's dementia, and Pick's

    disease)

    Contain abnormal proteins

    Plays a role in the

    development of symptoms

    May be a side effect of thedisease process

    Genetic make-up

    Result of complex interaction of

    genes, lifestyle factors, and other

    environmental influences

    What Causes Dementia?

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    What are the types of

    Dementia caused by

    Diseases?

    AlzheimersDisease

    Vascular (Multi-Infarct) Dementia

    Dementia with Lewy Bodies

    Fronto-Temporal Dementia

    OthersKorsakoffs syndrome

    HIV and AIDS Creutzfeldt-Jakob disease

    Parkinsons disease

    Huntingtons disease

    Motor Neurone disease Multiple Sclerosis

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    Alzheimers DiseaseFast Facts

    Alzheimers is the most common cause of dementia in people 65 years and older

    Up to 4 million people in US are living with the disease

    At least 360,000 Americans are diagnosed with Alzheimer's disease each year and

    about 50,000 are reported to die from it. In most people, symptoms of Alzheimer's disease appear after age 60.

    There are some early-onset forms of the disease, usually linked to a specific gene

    defect, which may appear as early as age 30.

    Alzheimer's disease usually causes a gradual decline in

    thinking abilities, usually during a span of 7 to 10 years.

    Nearly all brain functions, including memory, movement,language, judgment, behavior, and abstract thinking, are

    eventually affected.

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    AugusteDeter was the first person reported (in 1901) to have the form of dementia

    now known as Alzheimer's disease. The disease is named after Alois Alzheimer, the

    German doctor who first described it. After Auguste Deter died in 1906, doctors

    examined her brain and found that it appeared shrunken and contained several

    unusual features; including strange clumps of protein called plaques and tangled

    fibers inside the nerve cells.

    A woman in her early 50s was admitted to a hospital because of increasingly odd

    behavior. Her family reported that she had been showing memory problems and

    strong feelings of jealousy. She also had become disoriented at home and was hiding

    objects. During a doctor's examination, the woman was unable to remember her

    husband's name, the year, or how long she had been at the hospital. She could read

    but did not seem to understand what she read, and she stressed the words in an

    unusual way. She sometimes became agitated and seemed to have hallucinations

    and irrational fears.

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    Alzheimer's disease is characterized by two abnormalities in the brain:

    Amyloid Plaques

    Found in the tissue between the nerve cells Unusual clumps of protein called beta amyloid along with degenerating bits

    of neurons and other cells

    Neurofibrillary Tangles

    Bundles of twisted filaments found within neurons.

    Largely made up of a protein called tau In healthy neurons, the tau protein helps the functioning of microtubules,

    which are part of the cell's structural support and deliver substances

    throughout the nerve cell.

    In Alzheimer's disease, tau is changed in a way that

    causes it to twist into pairs of helical filaments that collect

    into tangles. When this happens, the microtubules cannotfunction correctly and they disintegrate. This collapse of

    the neuron's transport system may impair communication

    between nerve cells and cause them to die.

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    Vascular (Multi-Infarct) DementiaFast

    Facts

    Vascular dementia is the second most common cause of dementia.

    Caused by brain damage from cerebrovascular or cardiovascular problems -

    usually strokes.

    It also may result from genetic diseases, endocarditis (infection of a heart

    valve), or amyloid angiopathy (a process in which amyloid protein builds up in

    the brain's blood vessels, sometimes causing hemorrhagic or "bleeding"

    strokes).

    In many cases, it may coexist with Alzheimer's disease.

    Unlike people with Alzheimer's disease, people with

    vascular dementia often maintain their personality and

    normal levels of emotional responsiveness until the later

    stages of the disease.

    People with vascular dementia frequently wander

    at night and often have other problems commonly

    found in people who have had a stroke, including

    depression and incontinence.

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    Types of Vascular Dementia:

    Multi-infarct dementia (MID) Caused by numerous small strokes in the brain

    Typically includes multiple damaged areas, called infarcts, along with

    extensive lesions in the white matter, or nerve fibers, of the brain

    Single-infarct Dementia

    In some cases a single stroke can damage the brain enough to cause

    dementia Dementia is more common when the stroke takes place on the left side

    (hemisphere) of the brain and/or when it involves the hippocampus, a

    brain structure important for memory.

    Other types of vascular dementia include Binswanger's

    disease and CADASIL (cerebral autosomal dominant

    arteriopathy with subcortical infarct andleukoencephalopathy).

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    Lewy Body Dementia

    FASTFACTS

    One of the most common types of progressive dementia

    Usually occurs sporadically, in people with no known family history

    of the disease

    Cells die in the brain's cortex (outer layer), and in a part of the mid-

    brain called the substantia nigra Many of the remaining nerve cells in the substantia nigra contain

    abnormal structures called Lewy bodies that are the hallmark of the

    disease

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    Overlap with Alzheimer's disease in many ways

    May include memory impairment

    Poor judgment

    Confusion

    Visual hallucinations

    Shuffling gait (walk)

    Flexed posture

    Day-to-day fluctuations in the severity of symptoms.

    Patients with Lewy body dementia live an average of 7

    years after symptoms begin. There is no cure for Lewy

    body dementia, and treatments are aimed at controlling

    the Parkinsonian and psychiatric symptoms of the

    disorder.

    Symptoms of Lewy Body Dementia:

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    Fronto-Temporal Dementia

    FASTFACTS

    Sometimes called frontal lobe dementia

    A group of diseases characterized by degeneration of nerve cells - especially

    those in the frontal and temporal lobes of the brain

    Usually does not include formation of amyloid plaques

    In many people with frontotemporal dementia, there is an abnormal form oftau protein in the brain, which accumulates into neurofibrillary tangles. This

    disrupts normal cell activities and may cause the cells to die.

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    Accounts for 2% to 10% of all cases of dementia

    Symptoms usually appear between the ages of 40 and 65 In many cases, people with frontotemporal dementia have a family history of

    dementia, suggesting that there is a strong genetic factor in the disease.

    The duration of frontotemporal dementia varies, with some patients declining

    rapidly over 2 to 3 years and others showing only minimal changes for many years.

    People with frontotemporal dementia live with the disease for an average of 5 to

    10 years after diagnosis.

    People with frontotemporal dementia often have problems maintaining normal

    interactions and following social conventions.

    They may steal or exhibit impolite and socially inappropriate behavior, and they

    may neglect their normal responsibilities.

    Other common symptoms include loss of speech and language, compulsive or

    repetitive behavior, increased appetite, and motor problems such as stiffness and

    balance problems.

    Memory loss also may occur, although it typically appears late in the disease.

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    HIV-associated Dementia (HAD)

    Results from infection with the human immunodeficiency virus (HIV) that causes AIDS

    Can cause widespread destruction of the brain's white matter

    Leads to a type of dementia that generally includes impaired memory, apathy, socialwithdrawal, and difficulty concentrating

    People with HIV-associated dementia often develop movement problems as well.

    No specific treatment for HIV-associated dementia, but AIDS drugs can delay onset of the

    disease and may help to reduce symptoms.

    Huntington's Disease

    A hereditary disorder caused by a faulty gene for a protein called

    Huntington

    Causes degeneration in many regions of the brain and spinal cord

    Symptoms of Huntington's disease usually begin when patients are in

    their thirties or forties, and the average life expectancy after diagnosis is

    about 15 years Cognitive symptoms of Huntington's disease typically begin with mild

    personality changes, such as irritability, anxiety, and depression, and

    progress to severe dementia

    Many patients also show psychotic behavior

    Causes chorea - involuntary jerky, arrhythmic movements of the body -

    as well as muscle weakness, clumsiness, and gait disturbances

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    Dementia Pugilistica

    Also called chronic traumatic encephalopathy or Boxer's syndrome

    Caused by head trauma, such as that experienced by people who have been punched many

    times in the head during boxing

    Most common symptoms of the condition are dementia and parkinsonism, which can appear

    many years after the trauma ends

    Affected individuals may also develop poor coordination and slurred speech

    A single traumatic brain injury may also lead to a disorder called posttraumatic dementia (PTD).

    Posttraumatic dementia is much like dementia pugilistica but usually also includes long-term

    memory problems Other symptoms vary depending on which part of the brain was damaged by the injury.

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    Dementias in Children

    While it is usually found in adults,

    dementia can also occur in

    children. Infections and poisoning

    can lead to dementia in people of

    any age. In addition, some

    disorders unique to children can

    cause dementia. These include

    Niemann-Pick disease, Batten

    disease and Lafora body disease.

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    What Other Conditions Can Cause Dementia?

    Reactions or side effects to medications Metabolic problems and endocrine abnormalities such as thyroid disease, hypoglycemia,

    too little (hyponatremia) or too much sodium or calcium (hypercalcemia), or the inabilityto absorb vitamin B12 (pernicious anemia)

    Nutritional deficiencies such as thiamine (vitamin B1), B6, or B12 and severe dehydration

    Infections such as meningitis, encephalitis, untreated syphilis, and Lyme disease

    Subdural hematomas where there is bleeding between the brain's surface and its outer

    covering (the dura)

    Poisoning such as exposure to lead, other heavy metals, alcohol, recreational drugs or o

    other poisonous substances Brain tumors

    Anoxia/hypoxia in which there is a diminished supply of oxygen to an organ's

    tissues, for example heart attack, severe asthma, heart surgery, smoke or carbon

    monoxide inhalation, or an overdose of anesthesia

    Heart and chronic lung problems disease that prevents the brain from

    receiving adequate oxygen, which can starve brain cells.

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    How Is Dementia Diagnosed?

    Ruling out of any treatable conditions, such as depression, normal pressure

    hydrocephalus, or vitamin B12 deficiency, which can cause similar symptoms.

    Asking questions about the patient's history

    Physical examination

    Neurological evaluations (balance, sensory function, reflexes, etc.)

    Cognitive and neuropsychological tests (memory, language skills, math skills, problems

    solving, etc.)

    Brain scans (computed tomographic (CT) scans and magnetic resonance imaging (MRI),etc.)

    Laboratory tests (blood tests, urinalysis, toxicology screen, thyroid tests, etc.)

    Psychiatric evaluation

    Presymptomatic testing (genetic tests)

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    Cognitive Training

    Medications for Symptoms

    Practice Tasks

    Behavior Modification

    Aromatherapy

    Massage Therapy

    Animal-assisted Therapy

    How is dementia treated?

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    Can Dementia be Prevented?

    People who maintain tight control over their glucose levels tend to score better on tests

    of cognitive function than those with poorly controlled diabetes. Several studies also have suggested that people who engage in intellectually stimulating

    activities, such as social interactions, chess, crossword puzzles, and playing a musical

    instrument, significantly lower their risk of developing Alzheimer's disease and other

    forms of dementia.

    Other preventive actions include lowering homocysteine (amino acids), lowering

    cholesterol levels, lowering blood pressure, exercise, education, controlling inflammation,and long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen,

    naproxen, and similar drugs.

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    What is Music Therapy?

    Music Therapy is the use of music and/or its musical

    elements (sound, rhythm, melody and harmony) by a

    qualified music therapist, with a client or group, in a process

    designed to facilitate and promote communication,

    relationships, learning, mobilization, expression, organization

    and other relevant therapeutic objectives in order to meet

    physical, emotional, mental, social and cognitive needs.

    - World Federation of Music Therapy, 1996

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    What conditions can music therapy address?

    Children/adolescents/adults with developmental or learning disabilities

    Alzheimers disease and other age-related conditions

    Substance abuse problems

    Brain injuries

    Physical disabilities

    Acute and chronic pain Mothers in labor

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    Who are qualified to practice?

    Depending on the state or the country, credited music therapy practitioners havedifferent qualifications.

    Credited by the Certification Board for Music Therapists

    May have masters degree in music therapy or in other clinical field (social

    work, mental health counseling, etc.)

    In New York, practitioners should be licensed as creative arts therapists and/orshould pass the examination

    Graduated from the music therapy PhD program (Temple Univ & Lesley Univ)

    Should be proficient in guitar, piano, voice, music theory,

    music history, reading music, improvisation, assessment,

    documentation, and other counseling and health care skills.

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    What are the techniques used in Music Therapy? Singing

    - Assists in developing proper breathing and articulation- Fosters social interaction when done in a group setting

    - Encourages reminiscence of the past

    - Calms down the anxious patient

    Playing instruments

    - Improves gross and fine motor coordination

    - Increases self-esteem and sense of satisfaction with the self

    Music improvisation and Songwriting

    - Encourages creativity

    - Serves as a means of self-expression

    - Facilitates sharing of thoughts

    Rhythm-based exercises

    - Improves motor skills, balance, coordination, gait, etc.

    - Establishes proper rhythm in doing practical things

    Listening to and discussing music

    - Develops attention and memory

    - Gives sense of predictability in the environment

    and hence promotes relaxation

    -

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    What are its benefits for patients with Dementia?

    maintains adequate levels of meaningful stimulation and interaction

    improves quality of life

    manages behaviral symptoms such as:

    agitation

    cognitive decline and memory loss

    moodiness

    communicative difficulties increases reality orientation

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    How does music therapy tackle with Dementia symptoms?

    Memory Deficits

    Past memories, images and personal experiences can all be stimulated by

    certain songs. Through interviews with patients and their caregivers, these

    specific songs are identified so that they can be applied in Music Therapy

    sessions.

    Familiar songs are used to stimulate memory.Musical improvisation is used to enhance self-expression when meaningful

    words are no longer possible.

    Rhythm-based activities are used to increase attention and focus.

    Phrases are put to music to aid memory recall.

    Improved memoryIncreased attention, motivation and focus

    Improved cognitive skills

    Increased self-expression

    Increased awareness of self and others

    Reduced agitation

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    Motor Development

    The music therapist uses musical instruments that require specific movements in

    order to meet these exercise needs. For most individuals, finding the motivation to

    exercise is sometimes difficult. Combining exercise with enjoyable, creative and

    successful musical experiences can often accelerate the rehabilitation process.

    Specialized equipment can be adapted to existing abilities, no matter how limited.

    Music making provides experiences that transcend the usual focus of exercise.

    Fine motor (dexterity) and/or gross motor (range of motion) activitiesRhythmic strengthening exercises

    Motivation, focus and attention

    Motion initiated in parts of the body that have limited movement

    Movement maintained in affected extremities

    Increased range of motionRepertoire of exercises built up so that a resident can

    perform independently with confidence

    Motivation to participate in daily activities

    Increased neuromuscular control

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    Speech Difficulty

    Many individuals have never sung before and are a bit hesitant to try singing as therapy. In

    such cases it is helpful to remember that everyone, even non-musicians, can use singing to

    promote vocal support, organize conversational speech and improve communication skills.The focus during the Musically Assisted Speech groups is language and speech

    improvement, not professional musical achievements.

    Music can organize and facilitate speech because it utilizes other areas of the brain involved

    in communication.

    Rhythm can aid in vocal production by organizing mechanisms involved in speech.

    Breathing exercises

    Articulation exercises

    Melodic phrasing

    Rhythmic vocalization

    Conversational phrases are embedded into familiar song phrases

    to support speechImproved Communication Skills: improved clarity and fluency,

    increased expressive speech and vocal range and volume.

    Increased confidence in communication attempts

    Enhanced expression

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    Emotional Instability

    Led by a music therapist with a specialty in psychotherapy, this session allows individuals to

    connect to feelings and express thoughts and emotions related to trauma.

    The music therapist facilitates specific music according to lyrics, familiar melody or even the

    key or tempo in order to facilitate self expression and provide emotional support.

    Not all feelings can be described verbally,

    By developing trust and a relationship with the therapist, deep feelings and emotions can be

    reached through music.

    Musical expression through improvised or composed music that focuses

    on a specific issue.

    Express verbally or non-verbally an emotional response to a piece of

    music as part of a treatment.

    Cope with feelings related to issues in the past as well as to those in the

    present, such as current injury, disease, loss of function or independence.

    Reduced pain and increased movements of relazation

    by experiencing the power of music.

    Intra and inter-personal communication stimulated

    through improvisational techniques and guided imagery to music.

    Coping skills are learned, practiced and mastered in

    relation to disease.

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    State of the Science

    Music therapy is a relatively new field which started in the United States in 1994.Now, there are several organizations which advocates the use of music as a

    therapeutic tool to treat various psychological and psychiatric problems. Among

    these are:

    American Music TherapyAssociation

    Institute forMusic and Neurologic Function

    - By Dr. Concetta Tomaino- Working on a project which provides iPods to patients

    with customized playlists

    Nordoff-Robbins Center forMusic Therapy

    -

    The Bonny Foundation

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    In the Philippines

    There are no practitioners of music therapy in the Philippines but there are

    Filipino licensed music therapists abroad such as:

    Aileen Ravalo-Voyles, MT-BC

    -Works with children with and without special needs in grou and indiv. Settings

    -Bachelors degree in Piano Performance in UP

    -Bachelors degree in Music Therapy in Colorado State Univ

    -Co-Eduation Chair for the Colorado Association for Music Therapy

    Karen Rae Sanchez, MT-BC-Founder/Director, In Harmony Music Therapy Services

    -Magna cum laude, Bachelor of Music in Music Therapy and minor in

    Speech and Language Pathology in University of Pacific in Stockton

    Rita Rich Antonia Abante, MT-BC

    -Summa cum laude, Berklee College of Music

    -Voice major in UP

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    Case Examples

    Hanna

    has vascular dementia

    almost blind

    had difficulty moving

    memory capacity reduced

    no psychopharmacological treatment

    declared that she was fond of music music could reduce her crying

    often anxious, restless and complained about back pain

    spent much of her time in bed

    during the operatta recordings, hummed to the melodies and remained

    sitting in her chair

    becomes agitated when music is stopped classical music eases her anxiety

    music made her sit in her chair without crying for longer time

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    Dan

    has vascular dementia

    independent in walking and movement bladder and bowel incontinence

    confusion and agitation

    hits or scratches the nurse staff

    during the first session, he was emotionally affected and cried because of the

    nostalgic songs after, he voluntarily participated in the music activities and spoke

    to nurses in a positive manner

    asks what they will sing next

    no agitated behavior during the sessions

    hitting and scratching while nurses change the diaper decreased

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    Sensory

    Inner Ear (Cochlea) sorts complex sounds into simple frequencies Transmission along separately tuned auditory nerve fibers as trains of

    neural discharges

    Auditory Cortex in the Temporal Lobe

    Frequency Map

    Different cells in the auditory system of the brain respond best to certainfrequencies

    Neighboring cells have overlapping tuning curves so that there is no gap

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    ResponseMcKenna & Weinberger (1980s)

    Cell responses varied with how tone is presented within a melody (contour).

    Rhythm Left temporal lobe brief stimuli presentation

    Right temporal lobe long stimuli presentation

    Harmony

    Auditory region in right temporal lobe

    Timbre

    Right temporal lobe activated by timbre discrimination tasks

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    Musicians vs. Non-musicians

    MUSI

    CIA

    NS

    - Has 25% more left-hemisphere

    auditory regions activated while

    listening to piano playing

    - Volume of auditory cortex is 130%

    larger

    - Enlarged finger representation in

    the cortex

    - Anterior corpus callosum of

    musicians is larger

    - Motor cortex and the cerebellum

    are larger

    Non- MUSI

    CIA

    NS

    - Has less gray matter

    - Smaller auditory cortex

    - Less response to musical stimuli

    - Anterior corpus callosum of

    musicians is smaller

    - Motor cortex and the cerebellum

    are smaller

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    EmotionalResponse to Music

    Damage on the temporal lobes including auditory cortical regions impair

    only musical comprehension but not musics capacity to evoke emotions

    Emotional response could be subcortical and could involve other brain

    regions such as the frontal lobe

    Blood and McGill (2001), consonant chords or pleasant-sounding music

    activates the right hemispheres orbitofrontal area; dissonant chordsor unpleasant music activates the right parahippocampal gyrus

    Blood and Zatorre (2001), brain regions that are have greater blood

    flow when a musician experiences chills are the amygdala,

    orbitofrontal cortex, ventral striatum, midbrain, and ventral medial

    prefrontal cortexall of which involved in the reward system

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    Case Example

    Woody

    large amount of plaque in the brain

    has memory loss

    no idea of what he did for a living, where he is living now, or what he did ten

    minutes ago

    still remembers the baritone part to almost every song that he sung could still perform in front of an audience

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    Music and rhythm find their way into thesecret places of the soul. - Plato